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Diarylethylamines: Difference between revisions
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|+ NMDAR binding affinities for five target 1,2-diphenylethylamines and reference compounds<ref> | |+ NMDAR binding affinities for five target 1,2-diphenylethylamines and reference compounds<ref name="Pharma2016">{{cite journal | journal=PLOS ONE | title=Pharmacological Investigations of the Dissociative ‘Legal Highs’ Diphenidine, Methoxphenidine and Analogues | volume=11 | issue=6 | pages=e0157021 | date=17 June 2016 | url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157021 | issn=1932-6203 | doi=10.1371/journal.pone.0157021}}</ref> | ||
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!Compound | !Compound | ||
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!K<sub>i</sub> ± SEM (nM) | !K<sub>i</sub> ± SEM (nM) | ||
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|[[PCP]]<ref> | |[[PCP]]<ref>{{cite journal | vauthors=((Wallach, J.)) | journal=UNIVERSITY OF THE SCIENCES IN PHILADELPHIA | title=Structure activity relationship (SAR) studies of arylcycloalkylamines as N-methyl-D-aspartate receptor antagonists | pages=626 | date= 2014 | url=https://www.semanticscholar.org/paper/Structure-activity-relationship-(SAR)-studies-of-as-Wallach/cc0f16999e363db74bd501f5a041083f6b0f6b5a}}</ref> | ||
| 91 ± 1.3 | | 91 ± 1.3 | ||
| 57.9 ± 0.8 | | 57.9 ± 0.8 | ||
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| 9.3 ± 1.3 | | 9.3 ± 1.3 | ||
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|colspan="3" style="text-align:center;" |<small>NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.<ref | |colspan="3" style="text-align:center;" |<small>NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.<ref name="Pharma2016"/></small> | ||
<small>*Diphenidine is sometimes referred to as DPH in scientific studies despite this name already being in common use and widely accepted as meaning [[diphenhydramine]], an unrelated substance.</small> | <small>*Diphenidine is sometimes referred to as DPH in scientific studies despite this name already being in common use and widely accepted as meaning [[diphenhydramine]], an unrelated substance.</small> | ||
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|+ Inhibition potencies of 1,2-diarylethylamines as monoamine transporter reuptake inhibitors.<ref | |+ Inhibition potencies of 1,2-diarylethylamines as monoamine transporter reuptake inhibitors.<ref name="Pharma2016"/> | ||
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|colspan="4" style="text-align:center;" |IC<sub>50</sub> ± SEM (μM) | |colspan="4" style="text-align:center;" |IC<sub>50</sub> ± SEM (μM) | ||
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|colspan="4" style="text-align:left;" |IC<sub>50</sub> values shown in μM. Hill slopes shown in parenthesis. ND-IC<sub>50</sub> values were not determined because compounds showed less than 50% inhibition of uptake at 10 μM during a preliminary screening. | |colspan="4" style="text-align:left;" |IC<sub>50</sub> values shown in μM. Hill slopes shown in parenthesis. ND-IC<sub>50</sub> values were not determined because compounds showed less than 50% inhibition of uptake at 10 μM during a preliminary screening. | ||
<small>Inhibition potencies of 1,2-diarylethylamines as monoamine transporter reuptake inhibitors.<ref | <small>Inhibition potencies of 1,2-diarylethylamines as monoamine transporter reuptake inhibitors.<ref name="Pharma2016"/></small> | ||
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