Pregabalin: Difference between revisions

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|{{effects/physical|

*'''[[Effect::Sedation]]''' - Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.

*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.

*'''[[Effect::Appetite enhancement]]''' - This effect is not particularly prominent, but is reported to occur in some people. It can have a synergistic effect when combined with [[cannabis]].

*'''[[Effect::Pain relief]]''' - Pregabalin is effective against certain types of chronic pain, particularly neuropathic pain, but not against acute pain.<ref> Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915349/</ref>

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* '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In large contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent.

*'''[[Effect::Ego inflation]]'''

*'''[[Effect::Novelty ~~enchantment~~]]'''

*'''[[Effect::Novelty enhancement]]'''

*'''[[Effect::Suggestibility enhancement]]'''

*'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances.

@@ Line 41: / Line 41: @@
 |{{effects/physical|
-*'''[[Effect::Sedation]]''' -  Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.
+*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' -  Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.
 *'''[[Effect::Appetite enhancement]]''' - This effect is not particularly prominent, but is reported to occur in some people. It can have a synergistic effect when combined with [[cannabis]].
 *'''[[Effect::Pain relief]]''' - Pregabalin is effective against certain types of chronic pain, particularly neuropathic pain, but not against acute pain.<ref> Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915349/</ref>
@@ Line 84: / Line 84: @@
 * '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In large contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent.
 *'''[[Effect::Ego inflation]]'''
-*'''[[Effect::Novelty enchantment]]'''
+*'''[[Effect::Novelty enhancement]]'''
 *'''[[Effect::Suggestibility enhancement]]'''
 *'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances.