Pregabalin: Difference between revisions

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*'''[[Effect::Analysis suppression]]'''

* '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In large contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent.

*'''[[Effect::Ego inflation]]'''

*'''[[Effect::Novelty enchantment]]'''

*'''[[Effect::Suggestibility enhancement]]'''

*'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances.

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*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, pregabalin can induce a mild dissociative state. The DPDR from pregabalin can be increased and made more ''negative'' (dysphoric) by sleep deprivation.

*'''[[Effect::Suicidal ideation]]''' - In very huge doses this effect can lead to suicide attempts, sleep deprivation may increase this effect.

*'''[[Effect::Psychosis]]''' - Even at medicinal doses, pregabalin has been shown to have psychotic side effects in minority of ~~its~~ users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.

*'''[[Effect::Psychosis]]''' - Even at medicinal doses, pregabalin has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.

*'''[[Effect::Mania]]''' - Even if pregabalin is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare.

*'''[[Effect::Thought deceleration]]'''

@@ Line 83: / Line 83: @@
 *'''[[Effect::Analysis suppression]]'''
 * '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In large contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent.
+*'''[[Effect::Ego inflation]]'''
+*'''[[Effect::Novelty enchantment]]'''
 *'''[[Effect::Suggestibility enhancement]]'''
 *'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances.
@@ Line 96: / Line 98: @@
 *'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, pregabalin can induce a mild dissociative state. The DPDR from pregabalin can be increased and made more ''negative'' (dysphoric) by sleep deprivation.
 *'''[[Effect::Suicidal ideation]]''' - In very huge doses this effect can lead to suicide attempts, sleep deprivation may increase this effect.
-*'''[[Effect::Psychosis]]''' - Even at medicinal doses, pregabalin has been shown to have psychotic side effects in minority of its users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.
+*'''[[Effect::Psychosis]]''' - Even at medicinal doses, pregabalin has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.
 *'''[[Effect::Mania]]''' - Even if pregabalin is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare.
 *'''[[Effect::Thought deceleration]]'''