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Cocoa: Difference between revisions
>David Hedlund |
>David Hedlund "Theobromine has a half-life of 10 hours but over 16% may be unmodified 48 h after a single dose of 10 mg/Kg." - pmid=25750625 |
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{{pharmacology}} | {{pharmacology}} | ||
The compounds theobromine, [[caffeine]], and [[phenethylamine]] are the main psychoactive constituents of cocoa. Caffeine and theobromine are metabolized by xanthine oxidase and phenethylamine is metabolized mainly by monoamine oxidase B. | The compounds theobromine, [[caffeine]], and [[phenethylamine]] are the main psychoactive constituents of cocoa. Caffeine and theobromine are metabolized by xanthine oxidase and phenethylamine is metabolized mainly by monoamine oxidase B. | ||
Theobromine has a half-life of 10 hours but over 16% may be unmodified 48 h after a single dose of 10 mg/Kg.<ref>{{cite journal |last1=Martínez-Pinilla |first1=E |last2=Oñatibia-Astibia |first2=A |last3=Franco |first3=R |title=The relevance of theobromine for the beneficial effects of cocoa consumption. |journal=Frontiers in pharmacology |date=2015 |volume=6 |pages=30 |doi=10.3389/fphar.2015.00030 |pmid=25750625 |pmc=4335269}}</ref> | |||
==Subjective effects== | ==Subjective effects== | ||