Serotonin: Difference between revisions

Line 7:

It is commonly referred to as one of many "happy hormones" amongst dopamine, oxytocin, and endorphins, these chemicals bring about feelings of happiness and wellbeing (although this is a major oversimplification).

Approximately 95% of the human body's serotonin is produced in the intestines, where it has been credited with effects related to hormonal, autocrine, paracrine, and endocrine actions. <ref>Terry, N., & Margolis, K. G. (2016). Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance. https://dx.doi.org/10.1007%2F164_2016_103</ref>What is not absorbed elsewhere in the body is synthesized into serotonergic [[neurons]] for use by the central nervous system or CNS, here the serotonergic neurons can regulate: sleep, appetite, sexual behavior, homeostasis/temperature regulation, pain, and cognition.

Approximately 95% of the human body's serotonin is produced in the intestines, where it has been credited with effects related to hormonal, autocrine, paracrine, and endocrine actions. <ref>Terry, N., & Margolis, K. G. (2016). Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance. https://dx.doi.org/10.1007%2F164_2016_103</ref> What is not absorbed elsewhere in the body is synthesized into serotonergic [[neurons]] for use by the central nervous system or CNS, here the serotonergic neurons can regulate: sleep, appetite, sexual behavior, homeostasis/temperature regulation, pain, and cognition.

Serotonin also affects pathological states such as: disorders connected to mood, anxiety, psychosis and pain.<ref>Chilmonczyk, Z., Bojarski, A. J., Pilc, A., & Sylte, I. (2015). Functional selectivity and antidepressant activity of serotonin 1A receptor ligands. International journal of molecular sciences, 16(8), 18474-18506.https://doi.org/10.3390%2Fijms160818474</ref>Having either too little or too much serotonin can have many negative effects.

Serotonin also affects pathological states such as: disorders connected to mood, anxiety, psychosis and pain.<ref>Chilmonczyk, Z., Bojarski, A. J., Pilc, A., & Sylte, I. (2015). Functional selectivity and antidepressant activity of serotonin 1A receptor ligands. International journal of molecular sciences, 16(8), 18474-18506.https://doi.org/10.3390%2Fijms160818474</ref> Having either too little or too much serotonin can have many negative effects.

In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.{{citation needed}}

@@ Line 7: / Line 7: @@
 It is commonly referred to as one of many "happy hormones" amongst dopamine, oxytocin, and endorphins, these chemicals bring about feelings of happiness and wellbeing (although this is a major oversimplification).
-Approximately 95% of the human body's serotonin is produced in the intestines, where it has been credited with effects related to hormonal, autocrine, paracrine, and endocrine actions. <ref>Terry, N., & Margolis, K. G. (2016). Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance. https://dx.doi.org/10.1007%2F164_2016_103</ref>What is not absorbed elsewhere in the body is synthesized into serotonergic [[neurons]] for use by the central nervous system or CNS, here the serotonergic neurons can regulate: sleep, appetite, sexual behavior, homeostasis/temperature regulation, pain, and cognition.
+Approximately 95% of the human body's serotonin is produced in the intestines, where it has been credited with effects related to hormonal, autocrine, paracrine, and endocrine actions. <ref>Terry, N., & Margolis, K. G. (2016). Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance. https://dx.doi.org/10.1007%2F164_2016_103</ref> What is not absorbed elsewhere in the body is synthesized into serotonergic [[neurons]] for use by the central nervous system or CNS, here the serotonergic neurons can regulate: sleep, appetite, sexual behavior, homeostasis/temperature regulation, pain, and cognition.
-Serotonin also affects pathological states such as: disorders connected to mood, anxiety, psychosis and pain.<ref>Chilmonczyk, Z., Bojarski, A. J., Pilc, A., & Sylte, I. (2015). Functional selectivity and antidepressant activity of serotonin 1A receptor ligands. International journal of molecular sciences, 16(8), 18474-18506.https://doi.org/10.3390%2Fijms160818474</ref>Having either too little or too much serotonin can have many negative effects.
+Serotonin also affects pathological states such as: disorders connected to mood, anxiety, psychosis and pain.<ref>Chilmonczyk, Z., Bojarski, A. J., Pilc, A., & Sylte, I. (2015). Functional selectivity and antidepressant activity of serotonin 1A receptor ligands. International journal of molecular sciences, 16(8), 18474-18506.https://doi.org/10.3390%2Fijms160818474</ref> Having either too little or too much serotonin can have many negative effects.
 In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.{{citation needed}}