Modafinil: Difference between revisions
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*'''[[DangerousInteraction::CYP2C19-substrates]]''' - Modafinil may prolonge the elimation of some anxyolitics like diazepam, propranolol and clomipramine, resulting in higher systemic exposure to those drugs.<ref name="rxlist">https://www.rxlist.com/provigil-drug.htm</ref> | *'''[[DangerousInteraction::CYP2C19-substrates]]''' - Modafinil may prolonge the elimation of some anxyolitics like diazepam, propranolol and clomipramine, resulting in higher systemic exposure to those drugs.<ref name="rxlist">https://www.rxlist.com/provigil-drug.htm</ref> | ||
Although Modafinil may cause nausea and acid reflex, it should not be taken together with omeprazole (which is a CYP2C19-substrate).<ref name="rxlist"/> | Although Modafinil may cause nausea and acid reflex, it should not be taken together with omeprazole (which is a CYP2C19-substrate).<ref name="rxlist" /> | ||
==Legal status== | ==Legal status== | ||
Modafinil is legally approved for medical purposes worldwide. However, it is illegal to sell and possess in most countries without a prescription. | Modafinil is legally approved for medical purposes worldwide. However, it is illegal to sell and possess in most countries without a prescription. | ||
*'''Austria:''' Modafinila is classed as NR (prescription only, repeated dispense prohibited) <ref>Rezeptverordnung | https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=10010358</ref> | |||
*'''Australia:''' Modafinil is listed as a Schedule 4 (prescription only) drug in Australia and it can be prescribed sleep apnea and narcolepsy.<ref>Modafinil Wikipedia | https://en.wikipedia.org/wiki/Modafinil</ref> | *'''Australia:''' Modafinil is listed as a Schedule 4 (prescription only) drug in Australia and it can be prescribed sleep apnea and narcolepsy.<ref>Modafinil Wikipedia | https://en.wikipedia.org/wiki/Modafinil</ref> | ||
*'''Canada:''' Modafinil is listed as a Schedule F prescription drug in Canada and can be prescribed for human and veterinary use.<ref>National Association of Pharmacy Regulatory Authorities - Regulations Amending the Food and Drug Regulations (1184 — Modafinil) | http://napra.ca/Content_Files/Files/FDR-Project1184-Modafinil-Oct122006.pdf</ref> | *'''Canada:''' Modafinil is listed as a Schedule F prescription drug in Canada and can be prescribed for human and veterinary use.<ref>National Association of Pharmacy Regulatory Authorities - Regulations Amending the Food and Drug Regulations (1184 — Modafinil) | http://napra.ca/Content_Files/Files/FDR-Project1184-Modafinil-Oct122006.pdf</ref> |