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Pregabalin: Difference between revisions
>Nutmeg enjoyer 11 m just fixed some typos |
>Cosmicmoons m Fixed some minor typos and removed capitalization of "pregabalin" in the middle of some sentences. |
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==Chemistry== | ==Chemistry== | ||
Pregabalin is a structural analog of [[GABA]] (gamma-aminobutyric acid), with an isobutyl group substituted on the beta carbon of the aminobutyric chain. Pregabalin is similar in structure to other [[Gabapentinoid|gabapentinoids]], such as [[gabapentin]] and [[phenibut]]. | Pregabalin is a structural analog of [[GABA]] (gamma-aminobutyric acid), with an isobutyl group substituted on the beta carbon of the aminobutyric chain. Pregabalin is similar in structure to other [[Gabapentinoid|gabapentinoids]], such as [[gabapentin]] and [[phenibut]]. Pregabalin contains a carboxylated chain of hexane called hexanoic acid. This carbon chain is substituted with an amine group through a methyl bridge in (S) conformation at R<sub>3</sub> and a methyl group at R<sub>5</sub>. | ||
==Pharmacology== | ==Pharmacology== | ||
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*'''[[Effect::Drifting]]''' | *'''[[Effect::Drifting]]''' | ||
*'''[[Effect::After images]]''' and *'''[[Effect::Frame rate suppression]]''' at high / very high doses. These 2 effects together can make your vision feel more 'slow'. | *'''[[Effect::After images]]''' and *'''[[Effect::Frame rate suppression]]''' at high / very high doses. These 2 effects together can make your vision feel more 'slow'. | ||
*'''[[Effect::Double vision]] | *'''[[Effect::Double vision]]'' - This effect is quite mild and inconsistently appears at high doses. Sleep deprivation might magnify this effect. | ||
====Hallucinatory states==== | ====Hallucinatory states==== | ||
While Pregabalin isn't commonly thought off as a ''trip'' drug, it still can cause | While Pregabalin isn't commonly thought off as a ''trip'' drug, it still can cause dissocative and even psychotic like effects at higher doses. Sleep deprivation and genetics might play a roll into the hallucinatory states of Pregabalin. Pregabalin's hallucinatory states are (but not limited to) : | ||
*'''[[Effect::Internal hallucination]]''' - At high dosages, one may experience dream-like states and [[hypnagogia]]. | *'''[[Effect::Internal hallucination]]''' - At high dosages, one may experience dream-like states and [[hypnagogia]]. | ||
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}} | }} | ||
{{effects/disconnective| | {{effects/disconnective| | ||
*'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at high doses. It results in feeling as if one's sense of vision is distant or vague and being viewed through a screen or window. However, | *'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at high doses. It results in feeling as if one's sense of vision is distant or vague and being viewed through a screen or window. However, pregabalin is rarely reported to cause [[holes, spaces and voids]] or [[Visual_disconnection#Structures|hallucinatory structures]] , it can in some users (sleep deprivation might enhance this effect) but it is far from the typical experience. Pressing on your eyes while sitting in a dark room on a high - very high dose may result in very mild [[structures]] and [[sceneries]] | ||
}} | }} | ||
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*'''[[Effect::Disinhibition]]''' | *'''[[Effect::Disinhibition]]''' | ||
*'''[[Effect::Dream potentiation]]''' | *'''[[Effect::Dream potentiation]]''' | ||
*'''[[Effect::Increased music appreciation]]''' - The music | *'''[[Effect::Increased music appreciation]]''' - The music enhancement from pregabalin can be described as music sounding more detailed, 'higher quality', and even slowed down on higher dosages. | ||
*'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion. | *'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion. | ||
*'''[[Effect::Immersion enhancement]]''' | *'''[[Effect::Immersion enhancement]]''' | ||
*'''[[Effect::Creativity enhancement]]''' - This effect is especially noticeable on higher doses. | *'''[[Effect::Creativity enhancement]]''' - This effect is especially noticeable on higher doses. | ||
*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, | *'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, pregabalin can induce a mild dissociative state. The DPDR from Pregabalin can be increased and made more ''negative'' (less euphoric) by sleep deprivation. | ||
*'''[[Effect::Suicidal ideation]]''' - In very huge doses this effect can lead to suicide attempts, sleep deprivation may increase this effect. | *'''[[Effect::Suicidal ideation]]''' - In very huge doses this effect can lead to suicide attempts, sleep deprivation may increase this effect. | ||
*'''[[Effect::Psychosis]]''' - Even at medicinal doses, | *'''[[Effect::Psychosis]]''' - Even at medicinal doses, pregabalin has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia. | ||
*'''[[Effect::Mania]]''' - Even if | *'''[[Effect::Mania]]''' - Even if pregabalin is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical Pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare. | ||
*'''[[Effect::Thought deceleration]]''' | *'''[[Effect::Thought deceleration]]''' | ||
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}} | }} | ||
{{effects/aftereffects| | {{effects/aftereffects| | ||
The effects during a [[offset]] of an [[Pregabalin]] experience are generally | The effects during a [[offset]] of an [[Pregabalin]] experience are generally posetive and more similar to an 'afterglow' rather then a 'hangover'. These effects are ussaly very mild compared to [[peak]] effects. The after effects of [[Pregabalin]] are: | ||
*'''[[Effect::Motivation enhancement]]''' - Pregabalin is usually mentally stimulating, and the ''afterglow'' is similar. Since the high is mostly gone, this can lead to productivity enhancement. | *'''[[Effect::Motivation enhancement]]''' - Pregabalin is usually mentally stimulating, and the ''afterglow'' is similar. Since the high is mostly gone, this can lead to productivity enhancement. | ||
*'''[[Effect::Increased music appreciation]]''' - This effect is not as strong as it would be in the high, but music is noticeably enhanced and sounds more detailed. | *'''[[Effect::Increased music appreciation]]''' - This effect is not as strong as it would be in the high, but music is noticeably enhanced and sounds more detailed. | ||