Depression: Difference between revisions

Line 83:

Adaptation can be separated into three phases, each with different physiological processes. Mineralocorticoid receptors regulate cortisol during periods of low HPA activity. Glucocorticoid receptors regulate response to stress and cortisol during high HPA activity.

* Baseline: unstimulated, non-stressed.

# Baseline: unstimulated, non-stressed.

* Stress reactivity: cortisol increases from baseline.

# Stress reactivity: cortisol increases from baseline.

* Stress recovery: following offset of the stressor, cortisol levels return to baseline.

# Stress recovery: following offset of the stressor, cortisol levels return to baseline.

Major Depression Disorder patients have impaired stress reactivity and recovery, with more severe depression being more impairing. They have greatly higher overall baseline cortisol that subsequently changes less in response to new stressors. This is exhibited behaviorally through higher overall negative emotions and less emotional reactivity to new negative stimuli.

@@ Line 83: / Line 83: @@
 Adaptation can be separated into three phases, each with different physiological processes. Mineralocorticoid receptors regulate cortisol during periods of low HPA activity. Glucocorticoid receptors regulate response to stress and cortisol during high HPA activity.
-* Baseline: unstimulated, non-stressed.
+# Baseline: unstimulated, non-stressed.
-* Stress reactivity: cortisol increases from baseline.
+# Stress reactivity: cortisol increases from baseline.
-* Stress recovery: following offset of the stressor, cortisol levels return to baseline.
+# Stress recovery: following offset of the stressor, cortisol levels return to baseline.
 Major Depression Disorder patients have impaired stress reactivity and recovery, with more severe depression being more impairing. They have greatly higher overall baseline cortisol that subsequently changes less in response to new stressors. This is exhibited behaviorally through higher overall negative emotions and less emotional reactivity to new negative stimuli.