Lorazepam: Difference between revisions

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'''Lorazepam''' (trade name '''Ativan''') is a [[psychoactive class::depressant]] substance of the [[chemical class::benzodiazepine]] class. Lorazepam is used for the short-term treatment of [[Anxiety|anxiety]], [[insomnia]], [[seizure|acute seizures]], and the sedation of hospitalized patients.<ref>Benzodiazepines and their effects | http://www.benzo.org.uk/hindmarch.htm</ref><ref>An Economic Evaluation of Propofol and Lorazepam for Critically Ill Patients Undergoing Mechanical Ventilation (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763279/</ref><ref>Status epilepticus: an evidence based guide (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226249/</ref><ref>Pharmacological Management of Acute Agitation | http://link.springer.com/article/10.2165%2F00003495-200565090-00003</ref>

Users should note ~~that~~ that with [[benzodiazepines]], [[Thienodiazepine#Discontinuation|sudden discontinuation]] can be dangerous or even life-threatening for long-term or heavy users. As a result, individuals who are physically dependent on this substance are advised to [[taper]] their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping use abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>

Users should note that with [[benzodiazepines]], [[Thienodiazepine#Discontinuation|sudden discontinuation]] can be dangerous or even life-threatening for long-term or heavy users. As a result, individuals who are physically dependent on this substance are advised to [[taper]] their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping use abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>

==Chemistry==

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 '''Lorazepam''' (trade name '''Ativan''') is a [[psychoactive class::depressant]] substance of the [[chemical class::benzodiazepine]] class. Lorazepam is used for the short-term treatment of [[Anxiety|anxiety]], [[insomnia]], [[seizure|acute seizures]], and the sedation of hospitalized patients.<ref>Benzodiazepines and their effects | http://www.benzo.org.uk/hindmarch.htm</ref><ref>An Economic Evaluation of Propofol and Lorazepam for Critically Ill Patients Undergoing Mechanical Ventilation (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763279/</ref><ref>Status epilepticus: an evidence based guide (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226249/</ref><ref>Pharmacological Management of Acute Agitation | http://link.springer.com/article/10.2165%2F00003495-200565090-00003</ref>
-Users should note that that with [[benzodiazepines]], [[Thienodiazepine#Discontinuation|sudden discontinuation]] can be dangerous or even life-threatening for long-term or heavy users. As a result, individuals who are physically dependent on this substance are advised to [[taper]] their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping use abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>
+Users should note that with [[benzodiazepines]], [[Thienodiazepine#Discontinuation|sudden discontinuation]] can be dangerous or even life-threatening for long-term or heavy users. As a result, individuals who are physically dependent on this substance are advised to [[taper]] their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping use abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>
 ==Chemistry==