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Promethazine: Difference between revisions
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*'''[[Effect::Sedation]]''' - Promethazine causes pronounced sedation and a general feeling of slowness, usually with the feeling of not wanting to move, this effect is normally considerably stronger than Diphenhydramine or Doxylamine and it is generally considered to be one of the most sedating antihistamines due to its high anticholinergic, H1 anagonist and weak D2 antagonist activity. | *'''[[Effect::Sedation]]''' - Promethazine causes pronounced sedation and a general feeling of slowness, usually with the feeling of not wanting to move, this effect is normally considerably stronger than Diphenhydramine or Doxylamine and it is generally considered to be one of the most sedating antihistamines due to its high anticholinergic, H1 anagonist and weak D2 antagonist activity. | ||
*'''[[Effect:: | *'''[[Effect::Muscle relaxation]]''' | ||
**'''[[Effect:: | **'''[[Effect::Physical Euphoria]]''' - This can lead to a very pleasant feeling of the entire body relaxing, feeling like warm gel. It is similar to but distinct from an [[opioid]]'s physical euphoria. {{citation needed}} | ||
*'''[[Effect::Increased heart rate]]''' and '''[[Effect::increased blood pressure]]'''<ref>Tsay, M. E., Procopio, G., Anderson, B. D., & Klein-Schwartz, W. (2015). Abuse and intentional misuse of promethazine reported to US poison centers: 2002 to 2012. Journal of addiction medicine, 9(3), 233-237. | PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/25822213</ref> - Anticholinergic activity at muscarinic acetylcholine receptors causes these effects. | *'''[[Effect::Increased heart rate]]''' and '''[[Effect::increased blood pressure]]'''<ref>Tsay, M. E., Procopio, G., Anderson, B. D., & Klein-Schwartz, W. (2015). Abuse and intentional misuse of promethazine reported to US poison centers: 2002 to 2012. Journal of addiction medicine, 9(3), 233-237. | PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/25822213</ref> - Anticholinergic activity at muscarinic acetylcholine receptors causes these effects. | ||
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*'''[[Effect::Anxiety]]''' - Promethazine can occasionaly cause paranoia and Anxiety due to delirium although it is rarer than that of Diphenhydramine, Doxylamine and chlorpheniramine. | *'''[[Effect::Anxiety]]''' - Promethazine can occasionaly cause paranoia and Anxiety due to delirium although it is rarer than that of Diphenhydramine, Doxylamine and chlorpheniramine. | ||
*'''[[Effect::Euphoria]]''' - Usually, promethazine causes minimal euphoria normally only in anxious individuals and can even be dysphoric, however when used at low doses and combined with an opioid such as codeine, oxycodone or hydrocodone, it can effectively potentiate the euphoric effect and allow for a lower opioid dose. | |||
*'''[[Effect::Emotion suppression]]''' - This effect is mild and occurs due to the mild weak antipsycotic effect, however much weaker than that of chlorpromazine or prochlorperazine.{{citation needed}} | *'''[[Effect::Emotion suppression]]''' - This effect is mild and occurs due to the mild weak antipsycotic effect, however much weaker than that of chlorpromazine or prochlorperazine.{{citation needed}} | ||
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*'''[[Effect::Depth perception distortions]]''' - This side effect is uncommon. | *'''[[Effect::Depth perception distortions]]''' - This side effect is uncommon. | ||
====Hallucinatory states==== | |||
*'''[[Effect::External hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - The threshold for halucinations on Promethazine is higher than other 1st generation antihistamines like Diphenhydramine and doxylamine, occurs mainly heavy doses and can be difficult to reach due to the user likely falling asleep before they can reach delirium, as Promethazine is extremely sedating at high doses. It can be comprehensively described through its [[Visual_effects:_Internal_hallucinations#Variations|variations]] as delirious in believability, controllable or autonomous in controllability and solid in style. The most common themes for these hallucinations include those of both everyday occurrences such as smoking phantom cigarettes, talking to people who are not there, seeing and feeling insects and immersion in sinister or nightmarish experiences. | |||
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - Relative to other [[hallucinogens]], this effect occurs briefly and spontaneously at moderate doses but becomes progressively extended in its occurrence and duration proportional to dosage before eventually becoming all-encompassing. It can be comprehensively described through its [[Visual_effects:_Internal_hallucinations#Variations|variations]] as delirious in believability, interactive in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style. [[Internal hallucinations]] may occur at lighter dosages than needed to cause [[external hallucinations]] and [[delirium]]. | |||
*'''[[Effect::Peripheral information misinterpretation]]''' | |||
*'''[[Effect::Shadow people]]''' | |||
*'''[[Effect::Transformations]]''' | |||
*'''[[Effect::Unspeakable horrors]]''' | |||
*'''[[Effect::Object activation]]''' | |||
}} | }} | ||