ETH-CAT: Difference between revisions

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'''Ethylcathinone''' (also known as '''Ethylpropion''', '''Ethcathinone''', and commonly as '''ETH-CAT''') is a [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class that produces [[stimulating]] and [[focus enhancement|focus enhancing]] effects when [[Routes of administration|administered]]. It is structurally related to [[cathinone]] and methcathinone (MCAT), which broadly shares the effects profile of [[amphetamine]] or [[methylphenidate]].

'''Ethylcathinone''' (also known as '''Ethylpropion''', '''Ethcathinone''', and commonly as '''ETH-CAT''') is a [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class that produces [[stimulating]] and [[focus enhancement|focus enhancing]] effects when [[Routes of administration|administered]]. It is structurally related to [[cathinone]] and [[methcathinone]] (MCAT), which broadly shares the effects profile of [[amphetamine]] or [[methylphenidate]].

Of the [[substituted cathinones]], ETH-CAT reportedly produces the most moderate and residually long-lasting stimulation, with subtle effects that persist well after the initial rush. It has been described as having a more functional than recreational character due to the limited euphoria it produces for a stimulant, although its short active duration can promote [[compulsive redosing]].

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Ethylcathinone, or ETH-CAT, is a synthetic [[alkaloid]] of the [[substituted cathinone]] class. Substituted cathinones are all derivatives of [[cathinone]], a stimulant substance which is structurally and functionally related to [[amphetamine]] and the principal active psychoactive component present in the [[khat]] plant (''Catha edulis''). The cathinone molecule is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH2) group at the end of an ethyl side-chain that contains ketone group in the beta position.

In distinction to its N-methylated lower homolog, methcathinone (M-CAT), ETH-CAT possesses an additional ethyl substitution at Rα. ETH-CAT can be thought of as the cathinone analog of [[ethylamphetamine]] given it has the same general formula, differing only by the addition of a single double-bonded oxygen (i.e. the ketone group).

In distinction to its N-methylated lower homolog, methcathinone (M-CAT), ETH-CAT possesses an additional ethyl substitution at Rα. ETH-CAT can be thought of as the cathinone analog of ethylamphetamine given it has the same general formula, differing only by the addition of a single double-bonded oxygen (i.e. the ketone group).

[[File:Substituted_cathinone.svg|thumbnail|right|215px|Cathinone substitutive structure.]]

==Pharmacology==

Although the effects of ETH-CAT have not been formally studied on the same level as traditional [[amphetamines]] or other substituted cathinones like [[methcathinone]], it is possible to speculate that like other simple [[substituted cathinone]], it most likely acts principally as a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]].<ref>Kelly, J. P. (2011). Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. ''Drug Testing and Analysis'', 3(7‐8), 439-453. https://doi.org/10.1002/dta.31</ref>

Although the effects of ETH-CAT have not been formally studied on the same level as traditional [[amphetamines]] or other substituted cathinones like methcathinone, it is possible to speculate that like other simple [[substituted cathinone]], it most likely acts principally as a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]].<ref>Kelly, J. P. (2011). Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. ''Drug Testing and Analysis'', 3(7‐8), 439-453. https://doi.org/10.1002/dta.31</ref>

The result of this is an effective increase in the levels of [[catecholamine]] [[neurotransmitters]] like [[dopamine]] and [[norepinephrine]] in the brain by binding to and partially blocking the transporter proteins that normally clear these neurotransmitters from the synaptic cleft. This enables dopamine and norepinephrine to accumulate between the [[synaptic cleft|synaptic clefts]] of key regions of the brain associated with reward, motivation, satisfaction and pleasure to extra-endogenous levels. This mechanism is thought to account for the [[Stimulation|stimulating]], [[Motivation enhancement|motivation enhancing]] and [[Euphoria|euphoric]] effects that this substance produces.

The result of this is an effective increase in the levels of catecholamine [[neurotransmitters]] like [[dopamine]] and [[norepinephrine]] in the brain by binding to and partially blocking the transporter proteins that normally clear these neurotransmitters from the synaptic cleft. This enables dopamine and norepinephrine to accumulate between the [[synaptic cleft|synaptic clefts]] of key regions of the brain associated with reward, motivation, satisfaction and pleasure to extra-endogenous levels. This mechanism is thought to account for the [[Stimulation|stimulating]], [[Motivation enhancement|motivation enhancing]] and [[Euphoria|euphoric]] effects that this substance produces.

==Subjective effects==

At low to moderate doses, ETH-CAT has been reported as being a relatively functional and effective amphetamine-like stimulant for performing general productivity tasks. It has a noticeably short duration of activity combined with a tendency to produce long-lasting residual stimulation well after the main effects have worn off, which can promote patterns of [[compulsive redosing]] in order to maintain a steady level of the desired amount of physical and cognitive [[stimulation]].

However, at higher doses, it becomes less of a productivity-oriented stimulant and takes on a recreational character, perhaps owing to the inherently distracting nature of the type of [[thought acceleration]] and [[cognitive euphoria]] it can induce. However, even at high doses, it is reported as falling short of many other, far more hedonic and recreational [[substituted cathinones]] such as [[mephedrone]], [[methylone]], and [[methcathinone]] (M-CAT).

However, at higher doses, it becomes less of a productivity-oriented stimulant and takes on a recreational character, perhaps owing to the inherently distracting nature of the type of [[thought acceleration]] and [[cognitive euphoria]] it can induce. However, even at high doses, it is reported as falling short of many other, far more hedonic and recreational [[substituted cathinones]] such as [[mephedrone]], [[methylone]], and methcathinone (M-CAT).

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 {{SubstanceBox/ETH-CAT}}
-'''Ethylcathinone''' (also known as '''Ethylpropion''', '''Ethcathinone''', and commonly as '''ETH-CAT''') is a [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class that produces [[stimulating]] and [[focus enhancement|focus enhancing]] effects when [[Routes of administration|administered]]. It is structurally related to [[cathinone]] and methcathinone (MCAT), which broadly shares the effects profile of [[amphetamine]] or [[methylphenidate]].
+'''Ethylcathinone''' (also known as '''Ethylpropion''', '''Ethcathinone''', and commonly as '''ETH-CAT''') is a [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class that produces [[stimulating]] and [[focus enhancement|focus enhancing]] effects when [[Routes of administration|administered]]. It is structurally related to [[cathinone]] and [[methcathinone]] (MCAT), which broadly shares the effects profile of [[amphetamine]] or [[methylphenidate]].
 Of the [[substituted cathinones]], ETH-CAT reportedly produces the most moderate and residually long-lasting stimulation, with subtle effects that persist well after the initial rush. It has been described as having a more functional than recreational character due to the limited euphoria it produces for a stimulant, although its short active duration can promote [[compulsive redosing]].
@@ Line 11: / Line 11: @@
 Ethylcathinone, or ETH-CAT, is a synthetic [[alkaloid]] of the [[substituted cathinone]] class. Substituted cathinones are all derivatives of [[cathinone]], a stimulant substance which is structurally and functionally related to [[amphetamine]] and the principal active psychoactive component present in the [[khat]] plant (''Catha edulis''). The cathinone molecule is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group at the end of an ethyl side-chain that contains ketone group in the beta position.
-In distinction to its N-methylated lower homolog, methcathinone (M-CAT), ETH-CAT possesses an additional ethyl substitution at R<sub>α</sub>. ETH-CAT can be thought of as the cathinone analog of [[ethylamphetamine]] given it has the same general formula, differing only by the addition of a single double-bonded oxygen (i.e. the ketone group).
+In distinction to its N-methylated lower homolog, methcathinone (M-CAT), ETH-CAT possesses an additional ethyl substitution at R<sub>α</sub>. ETH-CAT can be thought of as the cathinone analog of ethylamphetamine given it has the same general formula, differing only by the addition of a single double-bonded oxygen (i.e. the ketone group).
 [[File:Substituted_cathinone.svg|thumbnail|right|215px|Cathinone substitutive structure.]]
 ==Pharmacology==
-Although the effects of ETH-CAT have not been formally studied on the same level as traditional [[amphetamines]] or other substituted cathinones like [[methcathinone]], it is possible to speculate that like other simple [[substituted cathinone]], it most likely acts principally as a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]].<ref>Kelly, J. P. (2011). Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. ''Drug Testing and Analysis'', 3(7‐8), 439-453. https://doi.org/10.1002/dta.31</ref>
+Although the effects of ETH-CAT have not been formally studied on the same level as traditional [[amphetamines]] or other substituted cathinones like methcathinone, it is possible to speculate that like other simple [[substituted cathinone]], it most likely acts principally as a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]].<ref>Kelly, J. P. (2011). Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. ''Drug Testing and Analysis'', 3(7‐8), 439-453. https://doi.org/10.1002/dta.31</ref>
-The result of this is an effective increase in the levels of [[catecholamine]] [[neurotransmitters]] like [[dopamine]] and [[norepinephrine]] in the brain by binding to and partially blocking the transporter proteins that normally clear these neurotransmitters from the synaptic cleft. This enables dopamine and norepinephrine to accumulate between the [[synaptic cleft|synaptic clefts]] of key regions of the brain associated with reward, motivation, satisfaction and pleasure to extra-endogenous levels. This mechanism is thought to account for the [[Stimulation|stimulating]], [[Motivation enhancement|motivation enhancing]] and [[Euphoria|euphoric]] effects that this substance produces.
+The result of this is an effective increase in the levels of catecholamine [[neurotransmitters]] like [[dopamine]] and [[norepinephrine]] in the brain by binding to and partially blocking the transporter proteins that normally clear these neurotransmitters from the synaptic cleft. This enables dopamine and norepinephrine to accumulate between the [[synaptic cleft|synaptic clefts]] of key regions of the brain associated with reward, motivation, satisfaction and pleasure to extra-endogenous levels. This mechanism is thought to account for the [[Stimulation|stimulating]], [[Motivation enhancement|motivation enhancing]] and [[Euphoria|euphoric]] effects that this substance produces.
 ==Subjective effects==
 At low to moderate doses, ETH-CAT has been reported as being a relatively functional and effective amphetamine-like stimulant for performing general productivity tasks. It has a noticeably short duration of activity combined with a tendency to produce long-lasting residual stimulation well after the main effects have worn off, which can promote patterns of [[compulsive redosing]] in order to maintain a steady level of the desired amount of physical and cognitive [[stimulation]].
-However, at higher doses, it becomes less of a productivity-oriented stimulant and takes on a recreational character, perhaps owing to the inherently distracting nature of the type of [[thought acceleration]] and [[cognitive euphoria]] it can induce. However, even at high doses, it is reported as falling short of many other, far more hedonic and recreational [[substituted cathinones]] such as [[mephedrone]], [[methylone]], and [[methcathinone]] (M-CAT).
+However, at higher doses, it becomes less of a productivity-oriented stimulant and takes on a recreational character, perhaps owing to the inherently distracting nature of the type of [[thought acceleration]] and [[cognitive euphoria]] it can induce. However, even at high doses, it is reported as falling short of many other, far more hedonic and recreational [[substituted cathinones]] such as [[mephedrone]], [[methylone]], and methcathinone (M-CAT).
 {{Preamble/SubjectiveEffects}}