1cP-LSD: Difference between revisions

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'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (known as '''1cP-LSD''') is a novel ~~semisynthetic~~ [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It ~~induces~~ its ~~psychedelic~~ effects ~~by acting on~~ [[serotonin]] [[receptors]] in the brain.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref> ~~1cP-LSD is closely related to [[1P-LSD]] and [[LSD]]. It is reported to produce similar to identical effects.~~

'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (also known as '''1cP-LSD''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It is chemically similar to [[LSD]] and other LSD analogs like [[1B-LSD]], [[ALD-52]], and [[1P-LSD]]. Its mechanism of action is not well-studied, but is thought to produce its effects via stimulation of [[serotonin]] [[receptors]] in parts of the brain.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref>

~~Little is known about the pharmacology~~. ~~Incubation of 1CP‐LSD with human serum led to the formation of~~ LSD, ~~indicating that it may act as a~~ [[~~prodrug~~]] ~~for~~ LSD~~.<ref name="Brandt2020"></ref>~~

The origins of 1cP-LSD are not well-documented. Following 1P-LSD's prohibition in Germany, 1cP-LSD appeared on the online [[research chemical]] market in 2019.{{citation needed}} Like other LSD analogs, it was marketed as a legal alternative to LSD and 1P-LSD.

~~Characteristic effects include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]]~~, and ~~[[ego loss]]~~.

~~1cP~~-LSD ~~appeared on the online~~ [[~~research chemical~~]] ~~market~~ as a ~~new legal alternative to LSD when 1P-~~LSD ~~was prohibited in Germany~~.

[[Subjective effects]] are reportedly nearly-identical to [[LSD]] and include [[geometry|open and closed eye visuals]], [[time distortion]], [[conceptual thinking]], [[introspection|enhanced introspection]], [[euphoria]], and [[ego loss]]. A study found that incubation of 1cP‐LSD with human serum led to the formation of LSD, indicating that it may act as a [[prodrug]] for LSD.<ref name="Brandt2020"></ref> Anecdotal reports are consistent with this theory.

It is highly advised to use [[harm reduction practices]] if using this substance.

Limited data exist on the pharmacology, metabolism, and toxicity of 1cP-LSD. While it is presumed to have a [[LSD#Toxicity and harm potential|similar risk profile as LSD]] and its analogs, which are generally thought to be safe, more research is needed. It is highly advised to use [[harm reduction practices]] if using this substance.

==History and culture==

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-{{decree|type=notice|message=This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.}}
-{{headerpanel|{{Approval}}}}
 {{SummarySheet}}
 {{SubstanceBox/1cP-LSD}}
-'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (known as '''1cP-LSD''') is a novel semisynthetic [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It induces its psychedelic effects by acting on [[serotonin]] [[receptors]] in the brain.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref> 1cP-LSD is closely related to [[1P-LSD]] and [[LSD]]. It is reported to produce similar to identical effects.
+'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (also known as '''1cP-LSD''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It is chemically similar to [[LSD]] and other LSD analogs like [[1B-LSD]], [[ALD-52]], and [[1P-LSD]]. Its mechanism of action is not well-studied, but is thought to produce its effects via stimulation of [[serotonin]] [[receptors]] in parts of the brain.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref>
-Little is known about the pharmacology. Incubation of 1CP‐LSD with human serum led to the formation of LSD, indicating that it may act as a [[prodrug]] for LSD.<ref name="Brandt2020"></ref>
+The origins of 1cP-LSD are not well-documented. Following 1P-LSD's prohibition in Germany, 1cP-LSD appeared on the online [[research chemical]] market in 2019.{{citation needed}} Like other LSD analogs, it was marketed as a legal alternative to LSD and 1P-LSD.
-Characteristic effects include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]].
-cP-LSD appeared on the online [[research chemical]] market as a new legal alternative to LSD when 1P-LSD was prohibited in Germany.
+[[Subjective effects]] are reportedly nearly-identical to [[LSD]] and include [[geometry|open and closed eye visuals]], [[time distortion]], [[conceptual thinking]], [[introspection|enhanced introspection]], [[euphoria]], and [[ego loss]]. A study found that incubation of 1cP‐LSD with human serum led to the formation of LSD, indicating that it may act as a [[prodrug]] for LSD.<ref name="Brandt2020"></ref> Anecdotal reports are consistent with this theory.
-It is highly advised to use [[harm reduction practices]] if using this substance.
+Limited data exist on the pharmacology, metabolism, and toxicity of 1cP-LSD. While it is presumed to have a [[LSD#Toxicity and harm potential|similar risk profile as LSD]] and its analogs, which are generally thought to be safe, more research is needed. It is highly advised to use [[harm reduction practices]] if using this substance.
 ==History and culture==