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2C-T: Difference between revisions
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'''2,5-Dimethoxy-4-methylthiophenethylamine''' (also known as '''2C-T''') is a lesser-known [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class. It is a member of the [[2C-x family]] of psychedelic phenethylamines, all of which are close relatives to [[mescaline]]. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood. | '''2,5-Dimethoxy-4-methylthiophenethylamine''' (also known as '''2C-T''') is a lesser-known [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class. It is a member of the [[2C-x family]] of psychedelic phenethylamines, all of which are close relatives to [[mescaline]]. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood. | ||
2C-T was first synthesized as part of a collaboration between researchers [[David E. Nichols]] and [[Alexander Shulgin]].<ref>Nichols | 2C-T was first synthesized as part of a collaboration between researchers [[David E. Nichols]] and [[Alexander Shulgin]].<ref>{{cite journal|last1=Nichols|first1=D. E.|last2=Shulgin|first2=A. T.|author-link1=David E. Nichols|author-link2=Alexander Shulgin|year=1976|title=Sulfur Analogs of Psychotomimetic Amines|journal=Journal of Pharmaceutical Sciences|volume=65|issue=10|pages=1554–1556|doi=10.1002/jps.2600651040|pmid=978423|issn=1520-6017|eissn=0022-3549|oclc=01754726}}</ref> | ||
Its effects and synthesis is described in Shulgin's 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name=" | Its effects and synthesis is described in Shulgin's 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal039.shtml|chapter=#39. 2C-T}}</ref> | ||
2C-T's subjective effects are not well-characterized. Preliminary anecdotal reports appear to indicate it has some of the psychedelic effects of [[2C-T-2]] and [[2C-T-7]]. The effects of 2C-T have been described as being less visual and more tactile. | 2C-T's subjective effects are not well-characterized. Preliminary anecdotal reports appear to indicate it has some of the psychedelic effects of [[2C-T-2]] and [[2C-T-7]]. The effects of 2C-T have been described as being less visual and more tactile. | ||
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{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
Although only speculative, it is worth noting that if 2C-T does have [[MAOI]] effects this could indicate that 2C-T is more likely to induce [[serotonin syndrome]] or general [[neurotransmitter]] overload (especially at high dosages) than other [[serotonergic psychedelic|serotonergic psychedelics]].<ref>Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | | Although only speculative, it is worth noting that if 2C-T does have [[MAOI]] effects this could indicate that 2C-T is more likely to induce [[serotonin syndrome]] or general [[neurotransmitter]] overload (especially at high dosages) than other [[serotonergic psychedelic|serotonergic psychedelics]].<ref>{{cite journal|title=Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling|doi=10.1021/jm0493109|first1=A.|last1=Gallardo-Godoy|first2=A.|last2=Fierro|first3=T. H.|last3=McLean|first4=M.|last4=Castillo|first5=B. K.|last5=Cassels|first6=M.|last6=Reyes-Parada|first7=D. E.|last7=Nichols|author-link7=David E. Nichols|year=2005|volume=48|issue=7|pages=2407–2419|journal=Journal of Medicinal Chemistry|issn=0022-2623|eissn=1520-4804|oclc=39480771}}</ref> This may make it dangerous to combine it with other [[MAOIs]], [[stimulant]]s and certain substances which promotes the release of neurotransmitters such as [[serotonin]] or [[dopamine]]. These substances include but are not limited to: | ||
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==Legal status== | ==Legal status== | ||
*'''Canada''': 2C-T would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref> | *'''Canada''': 2C-T would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>{{cite web|url=http://isomerdesign.com/Cdsa/schedule.php?schedule=3§ion=ALL&structure=C|title=Schedule III|work=Controlled Drugs and Substances Act (CDSA)|publisher=Isomer Design|access-date=October 10, 2020}}</ref> | ||
*'''United Kingdom''': 2C-T is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref> | *'''United Kingdom''': 2C-T is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref> | ||
*'''United States''': 2C-T is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.{{citation needed}} | *'''United States''': 2C-T is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.{{citation needed}} | ||