LSA: Difference between revisions

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User reports describe the effects of LSA as primarily sedating and dream-like, with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics like [[LSD]], [[psilocybin mushrooms]], or [[mescaline]]. LSA is described as primarily bodily and cognitive with little visual effects. Many users report serious [[nausea]] and bodily discomfort ("body load") when taking LSA-containing seeds.

Like other psychedelics, LSA is not considered to be addictive.<ref>{{cite journal|last1=Lüscher|first1=Christian|last2=Ungless|first2=Mark A.|title=The Mechanistic Classification of Addictive Drugs|year=2006|journal=PLOS Medicine|volume=3|issue=11|doi=10.1371/journal.pmed.0030437|pmid=17105338|issn=1549-1277}}</ref> However, adverse reactions such as severe [[anxiety]], [[paranoia]], and [[psychosis]] are always possible, particularly among those who are predisposed to psychiatric disorders.<ref>{{cite journal|last=Strassmann|first=Rick|title=Adverse reactions to psychedelic drugs. A review of the literature|journal=Journal of Nervous and Mental Disease|volume=172|issue=10|pages=577–595|doi=10.1097/00005053-198410000-00001|pmid=6384428|year=1984|issn=0022-3018|oclc=1754691}}</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.

Like other [[psychedelics]], LSA is not considered to be addictive.<ref>{{cite journal|last1=Lüscher|first1=Christian|last2=Ungless|first2=Mark A.|title=The Mechanistic Classification of Addictive Drugs|year=2006|journal=PLOS Medicine|volume=3|issue=11|doi=10.1371/journal.pmed.0030437|pmid=17105338|issn=1549-1277}}</ref> However, adverse reactions such as severe [[anxiety]], [[paranoia]], and [[psychosis]] are always possible, particularly among those who are predisposed to psychiatric disorders.<ref>{{cite journal|last=Strassmann|first=Rick|title=Adverse reactions to psychedelic drugs. A review of the literature|journal=Journal of Nervous and Mental Disease|volume=172|issue=10|pages=577–595|doi=10.1097/00005053-198410000-00001|pmid=6384428|year=1984|issn=0022-3018|oclc=1754691}}</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.

==Chemistry==

LSA, or d-lysergic acid amide, is an organic alkaloid belonging to the [[lysergamide]] class. The chemical structure of LSA contains a core structure of lysergic acid with an amine functional group bound to RN. The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group.

LSA, or d-lysergic acid amide, is an organic [[alkaloid]] belonging to the [[lysergamide]] class. The chemical structure of LSA contains a core structure of lysergic acid with an amine functional group bound to RN. The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group.

LSA is a chiral compound with two stereocenters at R5 and R8. LSA, also called (+)-D-LSA, has an absolute configuration of (5''R'', 8''R''). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to LSD, with the exception being that LSA lacks the diethyl substitution of LSD at RN of its carboxamide group. It can be used as a precursor to LSD.

LSA is a chiral compound with two stereocenters at R5 and R8. LSA, also called (+)-D-LSA, has an absolute configuration of (5''R'', 8''R''). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to [[LSD]], with the exception being that LSA lacks the diethyl substitution of LSD at RN of its carboxamide group. It can be used as a precursor to LSD.

==Pharmacology==

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*'''[[Effect::Vasoconstriction]]'''{{citation needed}} - LSA is commonly reported to produce strong and pronounced feelings of vasoconstriction. This varies in its intensity between individuals but is often considered moderately to extremely uncomfortable in comparison to other [[psychedelics]]. This effect is commonly reported to cause joint and limb pains.

*'''[[Effect::Increased heart rate]]'''

*'''[[Effect::Increased blood pressure]]''' or '''[[Effect::Decreased blood pressure]]'''{{citation needed}} - LSA has been reported as being capable of producing both an increase and a decrease in blood pressure, sometimes alternating at different points in the experience, such as during the [[come up]] or [[offset]], although it is unclear how much of this is dependent on the seeds and variations in alkaloid contents.

*'''[[Effect::Increased blood pressure]]''' or '''[[Effect::Decreased blood pressure]]'''{{citation needed}} - LSA has been reported as being capable of producing both an increase and a decrease in blood pressure, sometimes alternating at different points in the experience, such as during the [[come up]] or [[offset]], although it is unclear how much of this is dependent on the seeds and variations in [[alkaloid]] contents.

*'''[[Effect::Muscle contractions]]''' & '''[[Effect::Muscle relaxation]]'''

*'''[[Effect::Muscle spasms]]'''

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[[Category:~~Psychoactive substance~~]]

[[Category:Alkaloid]]

[[Category:Lysergamide]]

[[Category:Psychedelic]]

[[Category:Entheogen]]

~~[[Category:Psychedelic]]~~

~~[[Category:Lysergamide]]~~

~~[[Category:Naturally-occurring]]~~

{{#set:Featured=true

@@ Line 11: / Line 11: @@
 User reports describe the effects of LSA as primarily sedating and dream-like, with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics like [[LSD]], [[psilocybin mushrooms]], or [[mescaline]]. LSA is described as primarily bodily and cognitive with little visual effects. Many users report serious [[nausea]] and bodily discomfort ("body load") when taking LSA-containing seeds.
-Like other psychedelics, LSA is not considered to be addictive.<ref>{{cite journal|last1=Lüscher|first1=Christian|last2=Ungless|first2=Mark A.|title=The Mechanistic Classification of Addictive Drugs|year=2006|journal=PLOS Medicine|volume=3|issue=11|doi=10.1371/journal.pmed.0030437|pmid=17105338|issn=1549-1277}}</ref> However, adverse reactions such as severe [[anxiety]], [[paranoia]], and [[psychosis]] are always possible, particularly among those who are predisposed to psychiatric disorders.<ref>{{cite journal|last=Strassmann|first=Rick|title=Adverse reactions to psychedelic drugs. A review of the literature|journal=Journal of Nervous and Mental Disease|volume=172|issue=10|pages=577–595|doi=10.1097/00005053-198410000-00001|pmid=6384428|year=1984|issn=0022-3018|oclc=1754691}}</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.
+Like other [[psychedelics]], LSA is not considered to be addictive.<ref>{{cite journal|last1=Lüscher|first1=Christian|last2=Ungless|first2=Mark A.|title=The Mechanistic Classification of Addictive Drugs|year=2006|journal=PLOS Medicine|volume=3|issue=11|doi=10.1371/journal.pmed.0030437|pmid=17105338|issn=1549-1277}}</ref> However, adverse reactions such as severe [[anxiety]], [[paranoia]], and [[psychosis]] are always possible, particularly among those who are predisposed to psychiatric disorders.<ref>{{cite journal|last=Strassmann|first=Rick|title=Adverse reactions to psychedelic drugs. A review of the literature|journal=Journal of Nervous and Mental Disease|volume=172|issue=10|pages=577–595|doi=10.1097/00005053-198410000-00001|pmid=6384428|year=1984|issn=0022-3018|oclc=1754691}}</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.
 ==Chemistry==
-LSA, or d-lysergic acid amide, is an organic alkaloid belonging to the [[lysergamide]] class. The chemical structure of LSA contains a core structure of lysergic acid with an amine functional group bound to R<sub>N</sub>. The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group.
+LSA, or d-lysergic acid amide, is an organic [[alkaloid]] belonging to the [[lysergamide]] class. The chemical structure of LSA contains a core structure of lysergic acid with an amine functional group bound to R<sub>N</sub>. The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group.
-LSA is a chiral compound with two stereocenters at R<sub>5</sub> and R<sub>8</sub>. LSA, also called (+)-D-LSA, has an absolute configuration of (5''R'', 8''R''). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to LSD, with the exception being that LSA lacks the diethyl substitution of LSD at R<sub>N</sub> of its carboxamide group. It can be used as a precursor to LSD.
+LSA is a chiral compound with two stereocenters at R<sub>5</sub> and R<sub>8</sub>. LSA, also called (+)-D-LSA, has an absolute configuration of (5''R'', 8''R''). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to [[LSD]], with the exception being that LSA lacks the diethyl substitution of LSD at R<sub>N</sub> of its carboxamide group. It can be used as a precursor to LSD.
 ==Pharmacology==
@@ Line 39: / Line 39: @@
 *'''[[Effect::Vasoconstriction]]'''{{citation needed}} - LSA is commonly reported to produce strong and pronounced feelings of vasoconstriction. This varies in its intensity between individuals but is often considered moderately to extremely uncomfortable in comparison to other [[psychedelics]]. This effect is commonly reported to cause joint and limb pains.
 *'''[[Effect::Increased heart rate]]'''
-*'''[[Effect::Increased blood pressure]]''' or '''[[Effect::Decreased blood pressure]]'''{{citation needed}} - LSA has been reported as being capable of producing both an increase and a decrease in blood pressure, sometimes alternating at different points in the experience, such as during the [[come up]] or [[offset]], although it is unclear how much of this is dependent on the seeds and variations in alkaloid contents.
+*'''[[Effect::Increased blood pressure]]''' or '''[[Effect::Decreased blood pressure]]'''{{citation needed}} - LSA has been reported as being capable of producing both an increase and a decrease in blood pressure, sometimes alternating at different points in the experience, such as during the [[come up]] or [[offset]], although it is unclear how much of this is dependent on the seeds and variations in [[alkaloid]] contents.
 *'''[[Effect::Muscle contractions]]''' & '''[[Effect::Muscle relaxation]]'''
 *'''[[Effect::Muscle spasms]]'''
@@ Line 243: / Line 243: @@
 <references />
-[[Category:Psychoactive substance]]
+[[Category:Alkaloid]]
+[[Category:Lysergamide]]
+[[Category:Psychedelic]]
 [[Category:Entheogen]]
-[[Category:Psychedelic]]
-[[Category:Lysergamide]]
-[[Category:Naturally-occurring]]
 {{#set:Featured=true