2-FA: Difference between revisions

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'''2-Fluoroamphetamine''' ('''2-FA''') is a ~~synthetic ring-substituted fluorinated~~ [[~~chemical~~ class::~~amphetamine~~]] ~~compound that is commonly reported to be capable~~ of ~~producing classical~~ [[~~psychoactive~~ class::~~stimulant~~]] ~~effects that are often compared to those produced by~~ [[amphetamine~~|dextroamphetamine~~]] ~~in duration~~, ~~potency~~ and ~~potential effectiveness as a study aid or productivity enhancer.<ref>http://drugs~~.~~tripsit.me/2-fa | Tripsit Factsheets - 2FA</ref>~~

'''2-Fluoroamphetamine''' (also known as '''2-FA''') is a novel [[effect class::stimulant]] substance of the [[chemical class::amphetamine]] class. It is a structural analog of [[amphetamine]] and is presumed to possess a similar mechanism of action, promoting the release of [[dopamine]] and [[norepinephrine]] in the brain.

2-FA is ~~one~~ part of a series of ~~modern [[designer drug|designer fluorinated~~ amphetamine analogs]] that includes ~~synthetic compounds like~~ [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]] ~~which~~ are known ~~for their~~ range of [[stimulant|stimulating]] and [[euphoria|euphoric]] effects, many of which have been ~~gaining popularity~~ as [[research chemical]] substitutes for classical street [[~~stimulant~~]]s.{{citation needed}} Of these, 2-FA is considered to be most [[amphetamine]]-like in its ~~core properties and~~ effects.

2-FA is part of a series of amphetamine analogs that first appeared on the online research chemical market in the 2010s.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881</ref> These compounds includes [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]]. These compounds are known to produce a range of [[stimulant|stimulating]] and [[euphoria|euphoric]] effects, many of which have been used as [[research chemical]] substitutes for classical street [[stimulants]] and [[entactogens]].{{citation needed}} Of these, 2-FA is considered to be most [[amphetamine]]-like in its [[subjective effects]]. It is commonly compared to the d-isomer of amphetamine (dexedrine).

It is commonly taken orally ~~in line with the prescribed usage instruction of stimulants used to treat ADHD~~. While capable of being taken via [[insufflation]] or [[vaporized|vaporization]], this has been reported to be highly unpleasant and ~~toxic feeling~~ compared to its parent compound. Despite ~~its popularity~~ as ~~a research chemical study aid~~, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.

2-FA is commonly taken orally. While capable of being taken via [[insufflation]] or [[vaporized|vaporization]], this has been reported to be highly unpleasant and noxious compared to its parent compound. Despite some users reporting efficacy as an alternative to prescription stimulants for ADHD, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.

2-FA is ~~rarely found on the streets, but sometimes sold as a grey market~~ [[~~research chemical~~]] ~~through online vendors.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-~~substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.~~gov/pubmed/20074881</ref>~~

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2-FA. It is highly advised to use [[harm reduction practices]] if using this substance.

==Chemistry==

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 {{SubstanceBox/2-FA}}
-'''2-Fluoroamphetamine''' ('''2-FA''') is a synthetic ring-substituted fluorinated [[chemical class::amphetamine]] compound that is commonly reported to be capable of producing classical [[psychoactive class::stimulant]] effects that are often compared to those produced by [[amphetamine|dextroamphetamine]] in duration, potency and potential effectiveness as a study aid or productivity enhancer.<ref>http://drugs.tripsit.me/2-fa | Tripsit Factsheets - 2FA</ref>
+'''2-Fluoroamphetamine''' (also known as '''2-FA''') is a novel [[effect class::stimulant]] substance of the [[chemical class::amphetamine]] class. It is a structural analog of [[amphetamine]] and is presumed to possess a similar mechanism of action, promoting the release of [[dopamine]] and [[norepinephrine]] in the brain.
--FA is one part of a series of modern [[designer drug|designer fluorinated amphetamine analogs]] that includes synthetic compounds like [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]] which are known for their range of [[stimulant|stimulating]] and [[euphoria|euphoric]] effects, many of which have been gaining popularity as [[research chemical]] substitutes for classical street [[stimulant]]s.{{citation needed}} Of these, 2-FA is considered to be most [[amphetamine]]-like in its core properties and effects.
+-FA is part of a series of amphetamine analogs that first appeared on the online research chemical market in the 2010s.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881</ref>  These compounds includes [[2-FMA]], [[3-FA]], [[3-FEA]] and [[4-FA]]. These compounds are known to produce a range of [[stimulant|stimulating]] and [[euphoria|euphoric]] effects, many of which have been used as [[research chemical]] substitutes for classical street [[stimulants]] and [[entactogens]].{{citation needed}} Of these, 2-FA is considered to be most [[amphetamine]]-like in its [[subjective effects]]. It is commonly compared to the d-isomer of amphetamine (dexedrine).
-It is commonly taken orally in line with the prescribed usage instruction of stimulants used to treat ADHD. While capable of being taken via [[insufflation]] or [[vaporized|vaporization]], this has been reported to be highly unpleasant and toxic feeling compared to its parent compound. Despite its popularity as a research chemical study aid, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.
+-FA is commonly taken orally. While capable of being taken via [[insufflation]] or [[vaporized|vaporization]], this has been reported to be highly unpleasant and noxious compared to its parent compound. Despite some users reporting efficacy as an alternative to prescription stimulants for ADHD, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.
--FA is rarely found on the streets, but sometimes sold as a grey market [[research chemical]] through online vendors.<ref>Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15639609</ref><ref>Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881</ref>
+Very little data exists about the pharmacological properties, metabolism, and toxicity of 2-FA. It is highly advised to use [[harm reduction practices]] if using this substance.
 ==Chemistry==