Proscaline: Difference between revisions

Line 1:

'''4-Propyloxy-3,5-dimethoxyphenethylamine''' (also known as '''proscaline''') is a lesser-known [[Psychoactive class::psychedelic]] substance of the [[Chemical class::phenethylamine]] class.<ref>Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml</ref> It is a structurally related to [[mescaline]] and belongs to a series of mescaline analogs that include [[isoproscaline]], [[escaline]] and [[allylescaline]].

~~'''~~4-~~Propyloxy-3~~,~~5-dimethoxyphenethylamine'''~~ (~~commonly known as '''Proscaline'''~~) ~~is a synthetic [[Psychoactive class~~:~~:psychedelic]] substance of~~ the [[~~Chemical class::phenethylamine~~]] chemical ~~class~~ that ~~produces modified mescaline-like~~ [[~~hallucinogenic]] effects when [[routes of administration|administered~~]].<ref>Alexander ~~Shulgin~~ - ~~PIHKAL~~ | ~~http~~://~~www.~~erowid.org/library/books_online/~~pihkal~~/~~pihkal140~~.~~shtml~~</ref> ~~It has structural and pharmacological properties similar to its parent drug~~ [[~~mescaline]] as well as to its analogs such as [[isoproscaline]], [[escaline~~]] and ~~[[allylescaline]]~~.

The synthesis of proscaline was first published by David E. Nichols in 1977.<ref>"Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60 mg, estimating its potency as five times that of [[mescaline]].<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented his findings in the 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). Proscaline appeared for sale on the online research chemical market in the 2010s.{{citation needed}}

~~The synthesis of proscaline was first published by David E. Nichols in 1977.<ref>"Lipophilicity~~ and ~~serotonin agonist activity in a series of 4~~-~~substituted mescaline analogues." Nichols DE~~, ~~Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same~~ time, [[~~Alexander Shulgin~~]] ~~sampled~~ and ~~evaluated the chemical at doses up to 60mg, estimating its potency as five times that of~~ [[~~mescaline~~]].~~<ref>Shulgin~~, ~~Alexander~~. ~~"Pharmacology Lab Notes #2". Lafayette~~, CA. ~~(1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented Proscaline~~ in ~~his 1991 book "[[PiHKAL]]: A Chemical Love Story"~~.

[[Subjective effects]] are similar to [[mescaline]] and include [[geometry|open and closed-eye visuals]], [[time distortion]], [[introspection|enhanced introspection]], [[conceptual thinking]], [[euphoria]], and [[ego loss]]. However, it is reported to produce significantly less visual effects, euphoria, and ego loss than mescaline. As a result of its limited recreational potential, demand for the substance is relatively limited. It may have potential utility as an adjunct in psychedelic therapy, although this has yet to be explored.

~~Today~~, proscaline is ~~primarily used as~~ a [[~~recreational drug use~~|~~recreational drug~~]], ~~rarely if ever sold on the streets and almost exclusively obtained as a grey area~~ [[~~research chemical~~]] ~~through the use of online vendors. It is relatively obscure and has only a short history of human use~~.

Very little data exists about the pharmacological properties, metabolism, and toxicity of proscaline. It is assumed to have a risk profile [[Mescaline#Toxicity and harm potential|similar to mescaline]], although this has not been confirmed in studies. It is highly advised to use [[harm reduction practices]] if using this substance.

==Chemistry==

@@ Line 1: / Line 1: @@
 {{SummarySheet}}
 {{SubstanceBox/Proscaline}}
+'''4-Propyloxy-3,5-dimethoxyphenethylamine''' (also known as '''proscaline''') is a lesser-known [[Psychoactive class::psychedelic]] substance of the [[Chemical class::phenethylamine]] class.<ref>Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml</ref> It is a structurally related to [[mescaline]] and belongs to a series of mescaline analogs that include [[isoproscaline]], [[escaline]] and [[allylescaline]].
-'''4-Propyloxy-3,5-dimethoxyphenethylamine''' (commonly known as '''Proscaline''') is a synthetic [[Psychoactive class::psychedelic]] substance of the [[Chemical class::phenethylamine]] chemical class that produces modified mescaline-like [[hallucinogenic]] effects when [[routes of administration|administered]].<ref>Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml</ref> It has structural and pharmacological properties similar to its parent drug [[mescaline]] as well as to its analogs such as [[isoproscaline]], [[escaline]] and [[allylescaline]].
+The synthesis of proscaline was first published by David E. Nichols in 1977.<ref>"Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60 mg, estimating its potency as five times that of [[mescaline]].<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented his findings in the 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). Proscaline appeared for sale on the online research chemical market in the 2010s.{{citation needed}}
-The synthesis of proscaline was first published by David E. Nichols in 1977.<ref>"Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of [[mescaline]].<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> Shulgin later documented Proscaline in his 1991 book "[[PiHKAL]]: A Chemical Love Story".
+[[Subjective effects]] are similar to [[mescaline]] and include [[geometry|open and closed-eye visuals]], [[time distortion]], [[introspection|enhanced introspection]], [[conceptual thinking]], [[euphoria]], and [[ego loss]]. However, it is reported to produce significantly less visual effects, euphoria, and ego loss than mescaline. As a result of its limited recreational potential, demand for the substance is relatively limited. It may have potential utility as an adjunct in psychedelic therapy, although this has yet to be explored.
-Today, proscaline is primarily used as a [[recreational drug use|recreational drug]], rarely if ever sold on the streets and almost exclusively obtained as a grey area [[research chemical]] through the use of online vendors. It is relatively obscure and has only a short history of human use.
+Very little data exists about the pharmacological properties, metabolism, and toxicity of proscaline. It is assumed to have a risk profile [[Mescaline#Toxicity and harm potential|similar to mescaline]], although this has not been confirmed in studies. It is highly advised to use [[harm reduction practices]] if using this substance.
 ==Chemistry==