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Ayahuasca: Difference between revisions
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>David Hedlund ===Potential antidepressant effects=== PMID: 29903051, https://clinicaltrials.gov/ct2/show/NCT02914769 |
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===Potential antidepressant effects=== | ===Potential antidepressant effects=== | ||
A 2015 preliminary report has found a significant reduction of up to 82% in depressive scores following ayahuasca administration.<ref>Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000100013&lng=en&nrm=iso&tlng=en</ref> The report concludes that "these results suggest that [ayahuasca] has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder." Its acute and fast-acting effects show promise for the treatment of depression as common antidepressants, such as fluoxetine (Prozac), take weeks to show significant effects and are simply ineffective for many users. | A 2015 preliminary report has found a significant reduction of up to 82% in depressive scores following ayahuasca administration.<ref>Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015000100013&lng=en&nrm=iso&tlng=en</ref> The report concludes that "these results suggest that [ayahuasca] has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder." Its acute and fast-acting effects show promise for the treatment of depression as common antidepressants, such as fluoxetine (Prozac), take weeks to show significant effects and are simply ineffective for many users. | ||
A 2016 placebo randomized controlled trial evaluated the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression with positive outcome.<ref>{{cite journal |last1=Palhano-Fontes |first1=F |last2=Barreto |first2=D |last3=Onias |first3=H |last4=Andrade |first4=KC |last5=Novaes |first5=MM |last6=Pessoa |first6=JA |last7=Mota-Rolim |first7=SA |last8=Osório |first8=FL |last9=Sanches |first9=R |last10=Dos Santos |first10=RG |last11=Tófoli |first11=LF |last12=de Oliveira Silveira |first12=G |last13=Yonamine |first13=M |last14=Riba |first14=J |last15=Santos |first15=FR |last16=Silva-Junior |first16=AA |last17=Alchieri |first17=JC |last18=Galvão-Coelho |first18=NL |last19=Lobão-Soares |first19=B |last20=Hallak |first20=JEC |last21=Arcoverde |first21=E |last22=Maia-de-Oliveira |first22=JP |last23=Araújo |first23=DB |title=Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. |journal=Psychological medicine |date=March 2019 |volume=49 |issue=4 |pages=655-663 |doi=10.1017/S0033291718001356 |pmid=29903051}}</ref><ref>{{cite web |title=Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression - Full Text View - ClinicalTrials.gov |url=https://clinicaltrials.gov/ct2/show/NCT02914769 |website=clinicaltrials.gov |language=en}}</ref> | |||
The mechanism by which ayahuasca produces antidepressant effects is not well known, but studies have hypothesized that the MAO-inhibitor and weak [[serotonin]] [[reuptake inhibitor]] effects of ayahuasca alkaloids may be of relevance. Research on the antidepressant potential of [[psilocin]] suggests that the subjective effects of 5-HT<sub>2A</sub> agonism also contribute to antidepressant effects, but further research is required to understand the effects of psychedelic drugs on depressive disorders. | The mechanism by which ayahuasca produces antidepressant effects is not well known, but studies have hypothesized that the MAO-inhibitor and weak [[serotonin]] [[reuptake inhibitor]] effects of ayahuasca alkaloids may be of relevance. Research on the antidepressant potential of [[psilocin]] suggests that the subjective effects of 5-HT<sub>2A</sub> agonism also contribute to antidepressant effects, but further research is required to understand the effects of psychedelic drugs on depressive disorders. | ||