Disinhibition: Difference between revisions

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Experience reports
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added potential negative consequences of disinhibition
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At its lower levels of intensity, disinhibition can allow one to overcome emotional apprehension and suppressed social skills in a manner that is moderated and controllable for the average person. This can often prove useful for those who suffer from social anxiety or a general lack of self-confidence.  
At its lower levels of intensity, disinhibition can allow one to overcome emotional apprehension and suppressed social skills in a manner that is moderated and controllable for the average person. This can often prove useful for those who suffer from social anxiety or a general lack of self-confidence.  


However, at its higher levels of intensity, the disinhibited individual may be completely unable to maintain any semblance of self-restraint, at the expense of politeness, sensitivity, or social appropriateness. This lack of constraint can be negative, neutral, or positive depending on the individual and their current environment.  
However, at higher levels of intensity, the disinhibited individual may be completely unable to maintain any semblance of self-restraint, at the expense of politeness, sensitivity, social appropriateness, or local laws and regulations. This lack of constraint can be negative, neutral, or positive depending on the individual and their current environment. The negative consequences of disinhibited behaviour range from relatively benign consequences (such as embarrassing oneself) to destructive and damaging ones (such as driving under the influence or committing criminal acts). 


Disinhibition is often accompanied by other coinciding effects such as [[amnesia]] and [[anxiety suppression]] in a manner which can further decrease the person's observance of and regard for social norms. It is most commonly induced under the influence of [[dosage#common|moderate]] [[dosage|dosages]] of [[GABAergic]] [[depressant|depressants]], such as [[alcohol]],<ref name="BettingerTopper2014">{{cite journal|last1=Bettinger|first1=Jill C.|last2=Topper|first2=Stephen M.|last3=Aguilar|first3=Sara C.|last4=Topper|first4=Viktoria Y.|last5=Elbel|first5=Erin|last6=Pierce-Shimomura|first6=Jonathan T.|title=Alcohol Disinhibition of Behaviors in C. elegans|journal=PLoS ONE|volume=9|issue=3|year=2014|pages=e92965|issn=1932-6203|doi=10.1371/journal.pone.0092965}}</ref> [[benzodiazepine|benzodiazepines]],<ref name="Paton2018">{{cite journal|last1=Paton|first1=Carol|title=Benzodiazepines and disinhibition: a review|journal=Psychiatric Bulletin|volume=26|issue=12|year=2018|pages=460–462|issn=0955-6036|doi=10.1192/pb.26.12.460}}</ref> [[phenibut]], and [[GHB]]. However, it may also occur under the influence of certain [[stimulant|stimulants]],<ref name="Fillmore2003">{{cite journal|last1=Fillmore|first1=M|title=Effects of d-amphetamine on behavioral control in stimulant abusers: the role of prepotent response tendencies|journal=Drug and Alcohol Dependence|volume=71|issue=2|year=2003|pages=143–152|issn=03768716|doi=10.1016/S0376-8716(03)00089-9}}</ref> [[entactogen|entactogens]],<ref name="AndoBenko2006">{{cite journal|last1=Ando|first1=Romeo D.|last2=Benko|first2=Anita|last3=Ferrington|first3=Linda|last4=Kirilly|first4=Eszter|last5=Kelly|first5=Paul A.T.|last6=Bagdy|first6=Gyorgy|title=Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test|journal=Neuropharmacology|volume=50|issue=7|year=2006|pages=884–896|issn=00283908|doi=10.1016/j.neuropharm.2005.12.010}}</ref> and [[dissociative|dissociatives]]<ref name="LissekGüntürkün2003">{{cite journal|last1=Lissek|first1=Silke|last2=Güntürkün|first2=Onur|title=Dissociation of Extinction and Behavioral Disinhibition: The Role of NMDA Receptors in the Pigeon Associative Forebrain during Extinction|journal=The Journal of Neuroscience|volume=23|issue=22|year=2003|pages=8119–8124|issn=0270-6474|doi=10.1523/JNEUROSCI.23-22-08119.2003}}</ref>.
Disinhibition is often accompanied by other coinciding effects such as [[amnesia]] and [[anxiety suppression]] in a manner which can further decrease the person's observance of and regard for social norms. It is most commonly induced under the influence of [[dosage#common|moderate]] [[dosage|dosages]] of [[GABAergic]] [[depressant|depressants]], such as [[alcohol]],<ref name="BettingerTopper2014">{{cite journal|last1=Bettinger|first1=Jill C.|last2=Topper|first2=Stephen M.|last3=Aguilar|first3=Sara C.|last4=Topper|first4=Viktoria Y.|last5=Elbel|first5=Erin|last6=Pierce-Shimomura|first6=Jonathan T.|title=Alcohol Disinhibition of Behaviors in C. elegans|journal=PLoS ONE|volume=9|issue=3|year=2014|pages=e92965|issn=1932-6203|doi=10.1371/journal.pone.0092965}}</ref> [[benzodiazepine|benzodiazepines]],<ref name="Paton2018">{{cite journal|last1=Paton|first1=Carol|title=Benzodiazepines and disinhibition: a review|journal=Psychiatric Bulletin|volume=26|issue=12|year=2018|pages=460–462|issn=0955-6036|doi=10.1192/pb.26.12.460}}</ref> [[phenibut]], and [[GHB]]. However, it may also occur under the influence of certain [[stimulant|stimulants]],<ref name="Fillmore2003">{{cite journal|last1=Fillmore|first1=M|title=Effects of d-amphetamine on behavioral control in stimulant abusers: the role of prepotent response tendencies|journal=Drug and Alcohol Dependence|volume=71|issue=2|year=2003|pages=143–152|issn=03768716|doi=10.1016/S0376-8716(03)00089-9}}</ref> [[entactogen|entactogens]],<ref name="AndoBenko2006">{{cite journal|last1=Ando|first1=Romeo D.|last2=Benko|first2=Anita|last3=Ferrington|first3=Linda|last4=Kirilly|first4=Eszter|last5=Kelly|first5=Paul A.T.|last6=Bagdy|first6=Gyorgy|title=Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test|journal=Neuropharmacology|volume=50|issue=7|year=2006|pages=884–896|issn=00283908|doi=10.1016/j.neuropharm.2005.12.010}}</ref> and [[dissociative|dissociatives]]<ref name="LissekGüntürkün2003">{{cite journal|last1=Lissek|first1=Silke|last2=Güntürkün|first2=Onur|title=Dissociation of Extinction and Behavioral Disinhibition: The Role of NMDA Receptors in the Pigeon Associative Forebrain during Extinction|journal=The Journal of Neuroscience|volume=23|issue=22|year=2003|pages=8119–8124|issn=0270-6474|doi=10.1523/JNEUROSCI.23-22-08119.2003}}</ref>.
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{{#ask:[[Category:Experience]][[Effect::Disinhibition]]|format=ul|Columns=2}}
{{#ask:[[Category:Experience]][[Effect::Disinhibition]]|format=ul|Columns=2}}
===See also===
===See also===
*[[Responsible use]]
*[[Responsible use]]
*[[Subjective effects index]]
*[[Subjective effects index]]
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*[[Benzodiazepines]]
*[[Benzodiazepines]]
*[[Alcohol]]
*[[Alcohol]]
===External links===
===External links===
* [https://en.wikipedia.org/wiki/Disinhibition Disinhibition (Wikipedia)]
 
*[https://en.wikipedia.org/wiki/Disinhibition Disinhibition (Wikipedia)]
 
===References===
===References===
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