4-FA: Difference between revisions

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==Subjective effects==

It is commonly reported that the first three to four hours of 4-FA present distinct [[~~entactogen~~]]ic effects that have been reported as feeling somewhat similar to MDMA although not quite as powerful. This is thought to correlate with the duration in which it is promoting the release of [[serotonin]] (in addition to [[dopamine]] and [[norepinephrine]]). After this first phase of the experience, the effect then shifts towards something which feels like classic [[amphetamine]] stimulation which can persist for an extended period.{{citation needed}}

It is commonly reported that the first three to four hours of 4-FA present distinct [[entactogenic]] effects that have been reported as feeling somewhat similar to MDMA although not quite as powerful. This is thought to correlate with the duration in which it is promoting the release of [[serotonin]] (in addition to [[dopamine]] and [[norepinephrine]]). After this first phase of the experience, the effect then shifts towards something which feels like classic [[amphetamine]] stimulation which can persist for an extended period.{{citation needed}}

'''Do not use 4-FA if you have a history of heart-related issues or experience a severe headache after its use.''' We have been made aware of a report released by Trimbos-instituut<ref>https://www.trimbos.nl/</ref> and Nationaal Vergiftigingen Informatie Centrum<ref>https://www.vergiftigingen.info/</ref> (NVIC), describing incidents of strokes after an increased use of 4-FA. In addition to the common amphetamine-like effects (agitation, anxiety, tachycardia, hypertension, chest pain et al.), serious cardio- and cerebrovascular complications have been reported, including rhythm (sinus arrhythmia, ventricular extrasystoles (bigeminy), conduction disturbances) and acute cardiac failure. Although a causal relationship has not been confirmed, when presented with a severe headache and lateralization after 4-FA usage, a medical evaluation at an emergency department should be conducted immediately. <ref>https://psychonautwiki.org/wiki/File:Behandeling-4-fa-intoxicatie.pdf</ref>

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*'''[[Effect::Cognitive fatigue]]'''

*'''[[Effect::Depression]]'''

*'''[[Sleep paralysis]]''' - Some users report a higher incidence of experiencing sleep paralysis after consuming 4-FA, usually only at higher doses.

*'''[[Effect::Sleep paralysis]]''' - Some users report a higher incidence of experiencing sleep paralysis after consuming 4-FA, usually only at higher doses.

*'''[[Effect::Irritability]]'''

*'''[[Effect::Motivation suppression]]'''

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===Tolerance and addiction potential===

As with other [[~~stimulant~~]]s, the chronic use of 4-FA can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

As with other [[stimulants]], the chronic use of 4-FA can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 4-FA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). This is how long it takes to reduce the tolerance for the stimulating effects. Tolerance for the [[Empathy, love, and sociability enhancement|entactogenic effects]] may take a longer period to reduce. 4-FA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[~~stimulant~~]]s]], meaning that after the consumption of 4-FA all [[~~stimulant~~]]s will have a reduced effect.

Tolerance to many of the effects of 4-FA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). This is how long it takes to reduce the tolerance for the stimulating effects. Tolerance for the [[Empathy, love, and sociability enhancement|entactogenic effects]] may take a longer period to reduce. 4-FA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulants]]]], meaning that after the consumption of 4-FA all [[stimulants]] will have a reduced effect.

===Psychosis===

@@ Line 16: / Line 16: @@
 ==Subjective effects==
-It is commonly reported that the first three to four hours of 4-FA present distinct [[entactogen]]ic effects that have been reported as feeling somewhat similar to MDMA although not quite as powerful. This is thought to correlate with the duration in which it is promoting the release of [[serotonin]] (in addition to [[dopamine]] and [[norepinephrine]]). After this first phase of the experience, the effect then shifts towards something which feels like classic [[amphetamine]] stimulation which can persist for an extended period.{{citation needed}}
+It is commonly reported that the first three to four hours of 4-FA present distinct [[entactogenic]] effects that have been reported as feeling somewhat similar to MDMA although not quite as powerful. This is thought to correlate with the duration in which it is promoting the release of [[serotonin]] (in addition to [[dopamine]] and [[norepinephrine]]). After this first phase of the experience, the effect then shifts towards something which feels like classic [[amphetamine]] stimulation which can persist for an extended period.{{citation needed}}
 '''Do not use 4-FA if you have a history of heart-related issues or experience a severe headache after its use.''' We have been made aware of a report released by Trimbos-instituut<ref>https://www.trimbos.nl/</ref> and Nationaal Vergiftigingen Informatie Centrum<ref>https://www.vergiftigingen.info/</ref> (NVIC), describing incidents of strokes after an increased use of 4-FA. In addition to the common amphetamine-like effects (agitation, anxiety, tachycardia, hypertension, chest pain et al.), serious cardio- and cerebrovascular complications have been reported, including rhythm (sinus arrhythmia, ventricular extrasystoles (bigeminy), conduction disturbances) and acute cardiac failure. Although a causal relationship has not been confirmed, when presented with a severe headache and lateralization after 4-FA usage, a medical evaluation at an emergency department should be conducted immediately. <ref>https://psychonautwiki.org/wiki/File:Behandeling-4-fa-intoxicatie.pdf</ref>
@@ Line 98: / Line 98: @@
 *'''[[Effect::Cognitive fatigue]]'''
 *'''[[Effect::Depression]]'''
-*'''[[Sleep paralysis]]''' - Some users report a higher incidence of experiencing sleep paralysis after consuming 4-FA, usually only at higher doses.
+*'''[[Effect::Sleep paralysis]]''' - Some users report a higher incidence of experiencing sleep paralysis after consuming 4-FA, usually only at higher doses.
 *'''[[Effect::Irritability]]'''
 *'''[[Effect::Motivation suppression]]'''
@@ Line 125: / Line 125: @@
 ===Tolerance and addiction potential===
-As with other [[stimulant]]s, the chronic use of 4-FA can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
+As with other [[stimulants]], the chronic use of 4-FA can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
-Tolerance to many of the effects of 4-FA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). This is how long it takes to reduce the tolerance for the stimulating effects. Tolerance for the [[Empathy, love, and sociability enhancement|entactogenic effects]] may take a longer period to reduce. 4-FA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulant]]s]], meaning that after the consumption of 4-FA all [[stimulant]]s will have a reduced effect.
+Tolerance to many of the effects of 4-FA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). This is how long it takes to reduce the tolerance for the stimulating effects. Tolerance for the [[Empathy, love, and sociability enhancement|entactogenic effects]] may take a longer period to reduce. 4-FA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulants]]]], meaning that after the consumption of 4-FA all [[stimulants]] will have a reduced effect.
 ===Psychosis===