Lisdexamfetamine: Difference between revisions

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==Pharmacology==

Lisdexamfetamine was developed with the goal of providing a long duration of effect that remains consistent throughout the day as well as reduced potential for abuse. The attachment of the amino acid lysine slows down the relative amount of dextroamphetamine that is released into the bloodstream ~~(lisdexamfetamine dimesylate converts into a total 29.7% its weight in dextroamphetamine)~~. Because no free dextroamphetamine is present in lisdexamfetamine capsules, dextroamphetamine does not become available through mechanical manipulation, such as crushing or simple extraction. There is, therefore, no way to speed up absorption via alternate [[routes of administration]], such as via [[insufflation]], [[vaporization]], or [[injection]], making the drug theoretically less abusable.

Lisdexamfetamine was developed with the goal of providing a long duration of effect that remains consistent throughout the day as well as reduced potential for abuse. The attachment of the amino acid lysine slows down the relative amount of dextroamphetamine that is released into the bloodstream. Because no free dextroamphetamine is present in lisdexamfetamine capsules, dextroamphetamine does not become available through mechanical manipulation, such as crushing or simple extraction. There is, therefore, no way to speed up absorption via alternate [[routes of administration]], such as via [[insufflation]], [[vaporization]], or [[injection]], making the drug theoretically less abusable.

===Pharmacokinetics===

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===Conversion rate===

~~Roughly 1/3~~ of the weight of lisdexamfetamine dimesylate (the usual prescribed form) is dexamphetamine, 30 mg lisdexamfetamine dimesylate is equivalent to 8.9 mg of dexamfetamine.<ref>https://www.medicines.org.uk/emc/medicine/27442/SPC/</ref><ref>http://www.uacap.org/uploads/3/2/5/0/3250432/stimulant_equivalency.pdf</ref> The subjective experience will differ due to the slower, more steady release of active substance in the [[prodrug]]. An equivalent dose of dexamphetamine will have a higher peak plasma concentration and shorter duration.

29.7% of the weight of lisdexamfetamine dimesylate (the usual prescribed form) is dexamphetamine: 30 mg lisdexamfetamine dimesylate is equivalent to 8.9 mg of dexamfetamine,<ref>https://www.medicines.org.uk/emc/medicine/27442/SPC/</ref><ref>http://www.uacap.org/uploads/3/2/5/0/3250432/stimulant_equivalency.pdf</ref>

The subjective experience will differ due to the slower, more steady release of active substance in the [[prodrug]]. An equivalent dose of dexamphetamine will have a higher peak plasma concentration and shorter duration.

==Subjective effects==

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 ==Pharmacology==
-Lisdexamfetamine was developed with the goal of providing a long duration of effect that remains consistent throughout the day as well as reduced potential for abuse. The attachment of the amino acid lysine slows down the relative amount of dextroamphetamine that is released into the bloodstream (lisdexamfetamine dimesylate converts into a total 29.7% its weight in dextroamphetamine). Because no free dextroamphetamine is present in lisdexamfetamine capsules, dextroamphetamine does not become available through mechanical manipulation, such as crushing or simple extraction. There is, therefore, no way to speed up absorption via alternate [[routes of administration]], such as via [[insufflation]], [[vaporization]], or [[injection]], making the drug theoretically less abusable.
+Lisdexamfetamine was developed with the goal of providing a long duration of effect that remains consistent throughout the day as well as reduced potential for abuse. The attachment of the amino acid lysine slows down the relative amount of dextroamphetamine that is released into the bloodstream. Because no free dextroamphetamine is present in lisdexamfetamine capsules, dextroamphetamine does not become available through mechanical manipulation, such as crushing or simple extraction. There is, therefore, no way to speed up absorption via alternate [[routes of administration]], such as via [[insufflation]], [[vaporization]], or [[injection]], making the drug theoretically less abusable.
 ===Pharmacokinetics===
@@ Line 28: / Line 28: @@
 ===Conversion rate===
-Roughly 1/3 of the weight of lisdexamfetamine dimesylate (the usual prescribed form) is dexamphetamine, 30 mg lisdexamfetamine dimesylate is equivalent to 8.9 mg of dexamfetamine.<ref>https://www.medicines.org.uk/emc/medicine/27442/SPC/</ref><ref>http://www.uacap.org/uploads/3/2/5/0/3250432/stimulant_equivalency.pdf</ref> The subjective experience will differ due to the slower, more steady release of active substance in the [[prodrug]]. An equivalent dose of dexamphetamine will have a higher peak plasma concentration and shorter duration.
+.7% of the weight of lisdexamfetamine dimesylate (the usual prescribed form) is dexamphetamine: 30 mg lisdexamfetamine dimesylate is equivalent to 8.9 mg of dexamfetamine,<ref>https://www.medicines.org.uk/emc/medicine/27442/SPC/</ref><ref>http://www.uacap.org/uploads/3/2/5/0/3250432/stimulant_equivalency.pdf</ref>
+The subjective experience will differ due to the slower, more steady release of active substance in the [[prodrug]]. An equivalent dose of dexamphetamine will have a higher peak plasma concentration and shorter duration.
 ==Subjective effects==