4-AcO-DMT: Difference between revisions

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'''4-Acetoxy-N,N-dimethyltryptamine''' (also known as '''4-AcO-DMT''', '''4-Acetoxy-DMT''', '''O-Acetylpsilocin''', and '''psilacetin''') is a novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::tryptamine]] class. 4-AcO-DMT is chemically similar to [[psilocybin]], the active ingredient in [[psilocybin mushrooms]] ('''magic mushrooms'''). It belongs to a group known as the [[substituted tryptamines]] which act by stimulating [[serotonin]] [[receptors]] in the brain.

The synthesis of 4-AcO-DMT was first reported in 1963 by [[Albert Hofmann]] and Franz Troxler.<ref>http://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3075992</ref><ref>http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=3075992&KC=&FT=E&locale=en_EP</ref> However, its properties were not examined and no further studies were carried out. A 1999 paper by [[David E. Nichols]] suggested it as a useful alternative to psilocybin for pharmacological research.<ref>Nichols, D. E., & Frescas, S. (1999). Improvements to the synthesis of psilocybin and a facile method for preparing the O-acetyl prodrug of psilocin. Synthesis, 1999(6), 935-938. </ref> Reports of human use began to surface following its appearance on the online [[research chemical]] market in the 2010s.

The synthesis of 4-AcO-DMT was first reported in 1963 by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler.<ref>http://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3075992</ref><ref>http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=3075992&KC=&FT=E&locale=en_EP</ref> However, its properties were not examined and no further studies were carried out. A 1999 paper by [[David E. Nichols]] suggested it as a useful alternative to psilocybin for pharmacological research.<ref>Nichols, D. E., & Frescas, S. (1999). Improvements to the synthesis of psilocybin and a facile method for preparing the O-acetyl prodrug of psilocin. Synthesis, 1999(6), 935-938. </ref> Reports of human use began to surface following its appearance on the online [[research chemical]] market in the 2010s.

User reports indicate that the subjective effects of 4-AcO-DMT are near identical to those of [[psilocybin mushrooms]]. Like psilocybin, 4-AcO-DMT is theorized to act as a [[prodrug]] to [[psilocin]], which may account for this similarity. Characteristic effects include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]]. 4-AcO-DMT's classical psychedelic effects and favorable tolerability profile has led it to become popular among novel psychoactive substance users, particularly those seeking mystical-like or [[entheogenic]] experiences.

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 '''4-Acetoxy-N,N-dimethyltryptamine''' (also known as '''4-AcO-DMT''', '''4-Acetoxy-DMT''', '''O-Acetylpsilocin''', and '''psilacetin''') is a novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::tryptamine]] class. 4-AcO-DMT is chemically similar to [[psilocybin]], the active ingredient in [[psilocybin mushrooms]] ('''magic mushrooms'''). It belongs to a group known as the [[substituted tryptamines]] which act by stimulating [[serotonin]] [[receptors]] in the brain.
-The synthesis of 4-AcO-DMT was first reported in 1963 by [[Albert Hofmann]] and Franz Troxler.<ref>http://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3075992</ref><ref>http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=3075992&KC=&FT=E&locale=en_EP</ref> However, its properties were not examined and no further studies were carried out. A 1999 paper by [[David E. Nichols]] suggested it as a useful alternative to psilocybin for pharmacological research.<ref>Nichols, D. E., & Frescas, S. (1999). Improvements to the synthesis of psilocybin and a facile method for preparing the O-acetyl prodrug of psilocin. Synthesis, 1999(6), 935-938. </ref> Reports of human use began to surface following its appearance on the online [[research chemical]] market in the 2010s.
+The synthesis of 4-AcO-DMT was first reported in 1963 by [[wikipedia:Albert Hofmann|Albert Hofmann]] and Franz Troxler.<ref>http://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US3075992</ref><ref>http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=3075992&KC=&FT=E&locale=en_EP</ref> However, its properties were not examined and no further studies were carried out. A 1999 paper by [[David E. Nichols]] suggested it as a useful alternative to psilocybin for pharmacological research.<ref>Nichols, D. E., & Frescas, S. (1999). Improvements to the synthesis of psilocybin and a facile method for preparing the O-acetyl prodrug of psilocin. Synthesis, 1999(6), 935-938. </ref> Reports of human use began to surface following its appearance on the online [[research chemical]] market in the 2010s.
 User reports indicate that the subjective effects of 4-AcO-DMT are near identical to those of [[psilocybin mushrooms]]. Like psilocybin, 4-AcO-DMT is theorized to act as a [[prodrug]] to [[psilocin]], which may account for this similarity. Characteristic effects include [[geometry|geometric visual hallucinations]], [[time distortion]], [[introspection|enhanced introspection]], and [[ego loss]]. 4-AcO-DMT's classical psychedelic effects and favorable tolerability profile has led it to become popular among novel psychoactive substance users, particularly those seeking mystical-like or [[entheogenic]] experiences.