Melatonin: Difference between revisions

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'''N-Acetyl-5-methoxytryptamine''' (also known as '''melatonin'''<ref>Melatonin | http://www.sleepdex.org/melatonin.htm</ref>) is a hormone of the [[chemical class::tryptamine]] class. It is found in animals, plants, fungi, and bacteria. In animals, it functions as a hormone that anticipates the daily onset of darkness;<ref>Melatonin. | https://www.ncbi.nlm.nih.gov/pubmed/16219483</ref> it may have different functions in other organisms.

'''N-Acetyl-5-methoxytryptamine''' (~~commonly~~ known as '''melatonin'''<ref>Melatonin | http://www.sleepdex.org/melatonin.htm</ref>) is a hormone of the [[chemical class::tryptamine]] class. It is found in animals, plants, fungi, and bacteria. In animals, it functions as a hormone that anticipates the daily onset of darkness;<ref>Melatonin. | https://www.ncbi.nlm.nih.gov/pubmed/16219483</ref> it may have different functions in other organisms.

Melatonin is active and can be taken [[sublingual|sublingually]] and [[buccal|buccaly]] by placing it into one's mouth and allowing it to absorb over a period of 15-25 minutes. It is less active when taken [[oral|orally]].

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Melatonin, being a tryptamine, shares many structural properties with [[psychedelic]] substances. However, it lacks their associated psychedelic effects.<ref>Tihkal MELATONIN | https://erowid.org/library/books_online/tihkal/tihkal35.shtml</ref> Where many tryptamines have a group bonded to the ethylamine, melatonin has an acetyl group.

==Pharmacology==

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The median lethal dose of melatonin at which 50% of participants die ([[LD50|LD<sub>50</sub>]]) for human beings has never been reached in any setting.

===~~Tolerance~~ and ~~addiction~~ potential===

===Dependence and abuse potential===

Melatonin is [[Addiction potential::not habit-forming]]. It is possible, however, to develop a mild physical dependency if this compound is used on a nightly basis for a prolonged period. This simply means that if one suddenly stops their usage of the substance without tapering, they may have trouble sleeping for a couple of days afterward.

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==Legal status==

~~{{legalStub}}~~

*'''Canada:''' Melatonin is freely available to purchase as a dietary supplement and can be found at most pharmacies and grocery stores across the country.

*'''Germany:''' Melatonin is a prescription medicine, according to Anlage 1 AMVV.<ref>https://www.gesetze-im-internet.de/amvv/anlage_1.html</ref>

*'''India:''' Melatonin is legal to purchase as a dietary supplement.{{citation needed}}

*'''Italy:''' Melatonin is legal to purchase as a dietary supplement.{{citation needed}}

*'''Switzerland:''' Melatonin can only be obtained with a medical prescription. <ref>Circadin® 2 mg Retardtabletten sind in Apotheken nur gegen ärztliche Verschreibung erhältlich. | https://compendium.ch/mpub/pnr/1141302/html/de</ref>

*'''United Kingdom:''' Melatonin is a licensed prescription-only medicine (POM) in the United Kingdom.{{citation needed}} It is not a criminal offense to possess this medicine without a valid prescription. This medicine can legally be obtained with a valid prescription or through legal import of the medicine for personal use as outlined in Section 13 of the Medicines Act 1968.<ref>{{cite web |url = http://www.legislation.gov.uk/ukpga/1968/67/section/13|title = Medicines Act 1968 Section 13}}</ref>

*'''United States:''' Melatonin is listed as an uncontrolled substance and is legal to possess and distribute, and is freely available to purchase as a dietary supplement.

*'''Italy:''' Melatonin is legal to purchase as a dietary supplement.{{citation needed}}

*'''Switzerland:''' Melatonin can only be obtained with a medical prescription. <ref>Circadin® 2 mg Retardtabletten sind in Apotheken nur gegen ärztliche Verschreibung erhältlich. | https://compendium.ch/mpub/pnr/1141302/html/de</ref>

==See also==

*[[Responsible use]]

*[[Oneirogen]]

*[[Neurotransmitter]]

*[[Hormone]]

*[[Tryptamine]]

==External links==

*[https://en.wikipedia.org/wiki/Melatonin Melatonin (Wikipedia)]

*[https://erowid.org/smarts/melatonin/ Melatonin (Erowid Vault)]

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[[Category:Psychoactive substance]]

[[Category:Tryptamine]]

[[Category:Oneirogen]]

[[Category:Neurotransmitter]]

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 {{SummarySheet}}
 {{SubstanceBox/Melatonin}}
+'''N-Acetyl-5-methoxytryptamine''' (also known as '''melatonin'''<ref>Melatonin | http://www.sleepdex.org/melatonin.htm</ref>) is a hormone of the [[chemical class::tryptamine]] class. It is found in animals, plants, fungi, and bacteria. In animals, it functions as a hormone that anticipates the daily onset of darkness;<ref>Melatonin. | https://www.ncbi.nlm.nih.gov/pubmed/16219483</ref> it may have different functions in other organisms.
-'''N-Acetyl-5-methoxytryptamine''' (commonly known as '''melatonin'''<ref>Melatonin | http://www.sleepdex.org/melatonin.htm</ref>) is a hormone of the [[chemical class::tryptamine]] class. It is found in animals, plants, fungi, and bacteria. In animals, it functions as a hormone that anticipates the daily onset of darkness;<ref>Melatonin. | https://www.ncbi.nlm.nih.gov/pubmed/16219483</ref> it may have different functions in other organisms.
 Melatonin is active and can be taken [[sublingual|sublingually]] and [[buccal|buccaly]] by placing it into one's mouth and allowing it to absorb over a period of 15-25 minutes. It is less active when taken [[oral|orally]].
@@ Line 14: / Line 13: @@
 Melatonin, being a tryptamine, shares many structural properties with [[psychedelic]] substances. However, it lacks their associated psychedelic effects.<ref>Tihkal MELATONIN | https://erowid.org/library/books_online/tihkal/tihkal35.shtml</ref> Where many tryptamines have a group bonded to the ethylamine, melatonin has an acetyl group.
 ==Pharmacology==
 {{pharmacology}}
@@ Line 53: / Line 53: @@
 The median lethal dose of melatonin at which 50% of participants die ([[LD50|LD<sub>50</sub>]]) for human beings has never been reached in any setting.
-===Tolerance and addiction potential===
+===Dependence and abuse potential===
 Melatonin is [[Addiction potential::not habit-forming]]. It is possible, however, to develop a mild physical dependency if this compound is used on a nightly basis for a prolonged period. This simply means that if one suddenly stops their usage of the substance without tapering, they may have trouble sleeping for a couple of days afterward.
@@ Line 59: / Line 59: @@
 ==Legal status==
-{{legalStub}}
 *'''Canada:''' Melatonin is freely available to purchase as a dietary supplement and can be found at most pharmacies and grocery stores across the country.
 *'''Germany:''' Melatonin is a prescription medicine, according to Anlage 1 AMVV.<ref>https://www.gesetze-im-internet.de/amvv/anlage_1.html</ref>
 *'''India:''' Melatonin is legal to purchase as a dietary supplement.{{citation needed}}
+*'''Italy:''' Melatonin is legal to purchase as a dietary supplement.{{citation needed}}
+*'''Switzerland:''' Melatonin can only be obtained with a medical prescription. <ref>Circadin® 2 mg Retardtabletten sind in Apotheken nur gegen ärztliche Verschreibung erhältlich. | https://compendium.ch/mpub/pnr/1141302/html/de</ref>
 *'''United Kingdom:''' Melatonin is a licensed prescription-only medicine (POM) in the United Kingdom.{{citation needed}} It is not a criminal offense to possess this medicine without a valid prescription. This medicine can legally be obtained with a valid prescription or through legal import of the medicine for personal use as outlined in Section 13 of the Medicines Act 1968.<ref>{{cite web |url = http://www.legislation.gov.uk/ukpga/1968/67/section/13|title = Medicines Act 1968 Section 13}}</ref>
 *'''United States:''' Melatonin is listed as an uncontrolled substance and is legal to possess and distribute, and is freely available to purchase as a dietary supplement.
-*'''Italy:''' Melatonin is legal to purchase as a dietary supplement.{{citation needed}}
-*'''Switzerland:''' Melatonin can only be obtained with a medical prescription. <ref>Circadin® 2 mg Retardtabletten sind in Apotheken nur gegen ärztliche Verschreibung erhältlich. | https://compendium.ch/mpub/pnr/1141302/html/de</ref>
 ==See also==
 *[[Responsible use]]
+*[[Oneirogen]]
 *[[Neurotransmitter]]
 *[[Hormone]]
+*[[Tryptamine]]
 ==External links==
 *[https://en.wikipedia.org/wiki/Melatonin Melatonin (Wikipedia)]
 *[https://erowid.org/smarts/melatonin/ Melatonin (Erowid Vault)]
@@ Line 87: / Line 85: @@
 [[Category:Psychoactive substance]]
 [[Category:Tryptamine]]
+[[Category:Oneirogen]]
 [[Category:Neurotransmitter]]