Promethazine: Difference between revisions

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Promethazine, because of its extensive pharmacology, has many interactions. According to the interactions checker on [https://www.drugs.com| Drugs.com], promethazine is known to interact with over 1000 other prescription and OTC drugs.

*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should try to fall asleep in the [[recovery position]] or have a friend move them into it.

*''[[Dopamine|Anti-dopaminergics]]'' - Because promethazine also blocks dopamine receptors, other drugs and substances that do this will increase the chances of developing acute or tardive dyskinesia, neuroleptic malignant syndrome, or parkinsonism. {{citation needed}}

*'''[[Dopamine|Anti-dopaminergics]]''' - Because promethazine also blocks dopamine receptors, other drugs and substances that do this will increase the chances of developing acute or tardive dyskinesia, neuroleptic malignant syndrome, or parkinsonism. {{citation needed}}

*''[[Acetylcholine|Anticholinergics]]'' - Promethazine with anticholinergics (or antimuscarinics) can cause increased blocking of acetylcholine, being potentially dangerous with cardiovascular effects as well as delirium. {{citation needed}}

*'''[[Acetylcholine|Anticholinergics]]''' - Promethazine with anticholinergics (or antimuscarinics) can cause increased blocking of acetylcholine, being potentially dangerous with cardiovascular effects as well as delirium. {{citation needed}}

*'''[[Stimulants]]''' - Due to promethazine's excitatory cardiac effect, combining it with stimulants poses a risk of an abnormal heart rhythm, severe tachycardia, or a heart attack as well as other cardiovascular events.

==Legal status==

@@ Line 43: / Line 43: @@
 Promethazine, because of its extensive pharmacology, has many interactions. According to the interactions checker on [https://www.drugs.com| Drugs.com], promethazine is known to interact with over 1000 other prescription and OTC drugs.
-*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should try to fall asleep in the [[recovery position]] or have a friend move them into it.
+*''[[Dopamine|Anti-dopaminergics]]'' - Because promethazine also blocks dopamine receptors, other drugs and substances that do this will increase the chances of developing acute or tardive dyskinesia, neuroleptic malignant syndrome, or parkinsonism. {{citation needed}}
-*'''[[Dopamine|Anti-dopaminergics]]''' - Because promethazine also blocks dopamine receptors, other drugs and substances that do this will increase the chances of developing acute or tardive dyskinesia, neuroleptic malignant syndrome, or parkinsonism. {{citation needed}}
+*''[[Acetylcholine|Anticholinergics]]'' - Promethazine with anticholinergics (or antimuscarinics) can cause increased blocking of acetylcholine, being potentially dangerous with cardiovascular effects as well as delirium. {{citation needed}}
-*'''[[Acetylcholine|Anticholinergics]]''' - Promethazine with anticholinergics (or antimuscarinics) can cause increased blocking of acetylcholine, being potentially dangerous with cardiovascular effects as well as delirium. {{citation needed}}
-*'''[[Stimulants]]''' - Due to promethazine's excitatory cardiac effect, combining it with stimulants poses a risk of an abnormal heart rhythm, severe tachycardia, or a heart attack as well as other cardiovascular events.
 ==Legal status==
 {{LegalStub}}