Gabapentinoids: Difference between revisions

Line 1:

[[File:Gabapentinoidsstructure.png|250px|thumbnail|Diagram showing the structural similarities of [[GABA|gamma-aminobutyric acid]] (GABA), [[pregabalin]] and [[gabapentin]].]]

'''Gabapentinoids''' are a class of chemical compounds that are derivatives of [[GABA|gamma-aminobutyric acid]] which block α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels|channels]]. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.

Gabapentinoids are ~~commonly used for epilepsy, neuropathic pain, and [[restless legs syndrome]]. Gabapentinoids are often~~ [[~~Sedation|sedating~~]]~~, have~~ [[~~Seizure suppression~~|~~anticonvulsant]] effects, and [[Anxiety suppression|suppress anxiety~~]]. ~~Drugs in~~ this class include [[gabapentin]], [[F-phenibut]], [[phenibut]], [[baclofen]] and [[pregabalin]]. Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[~~benzodiazepine~~]]s, [[alcohol]] and [[~~opioid~~]]s.

'''Gabapentinoids''' are a chemical class of [[psychoactive substances]] derived from [[GABA|gamma-aminobutyric acid]] (GABA).{{citation needed}} Members of this class include [[gabapentin]], [[F-phenibut]], [[phenibut]], [[baclofen]] and [[pregabalin]].

=See also=

Gabapentinoids are commonly prescribed for epilepsy, neuropathic pain, and [[restless legs syndrome]]. [[Subjective effects]] include [[sedation]], [[muscle relaxation]], and [[anxiety suppression]].

Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepines]], [[alcohol]] and [[opioids]].

==Chemistry==

Gabapentinoids are 3-substituted derivatives of GABA. Hence, they are GABA analogues, as well as γ-amino acids.<ref>Elaine Wyllie; Gregory D. Cascino; Barry E. Gidal; Howard P. Goodkin (17 February 2012). Wyllie's Treatment of Epilepsy: Principles and Practice. Lippincott Williams & Wilkins. p. 423. ISBN 978-1-4511-5348-4.</ref><ref>Honorio Benzon; James P. Rathmell; Christopher L. Wu; Dennis C. Turk; Charles E. Argoff; Robert W Hurley (11 September 2013). Practical Management of Pain. Elsevier Health Sciences. p. 1006. ISBN 978-0-323-17080-2.</ref>

==Pharmacology==

Gabapentinoids act by blocking α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels|channels]] (VGCCs).{{citation needed}} While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.{{citation needed}}

==Examples==

*[[Baclofen]]

*[[F-Phenibut]]

*[[Gabapentin]]

*[[Phenibut]]

*[[Pregabalin]]

==See also==

*[[Responsible use]]

*[[Depressants]]

Line 14:

Line 31:

*[https://en.wikipedia.org/wiki/Gabapentinoid Gabapentinoid (Wikipedia)]

[[Category:Gabapentinoid]]

==References==

[[Category:Gabapentinoid]][[Category:Chemical class]]

@@ Line 1: / Line 1: @@
 {{Stub}}
 [[File:Gabapentinoidsstructure.png|250px|thumbnail|Diagram showing the structural similarities of [[GABA|gamma-aminobutyric acid]] (GABA), [[pregabalin]] and [[gabapentin]].]]
-'''Gabapentinoids''' are a class of chemical compounds that are derivatives of [[GABA|gamma-aminobutyric acid]] which block α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels|channels]]. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.
-Gabapentinoids are commonly used for epilepsy, neuropathic pain, and [[restless legs syndrome]]. Gabapentinoids are often [[Sedation|sedating]], have [[Seizure suppression|anticonvulsant]] effects, and [[Anxiety suppression|suppress anxiety]]. Drugs in this class include [[gabapentin]], [[F-phenibut]], [[phenibut]], [[baclofen]] and [[pregabalin]]. Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepine]]s, [[alcohol]] and [[opioid]]s.
+'''Gabapentinoids''' are a chemical class of [[psychoactive substances]] derived from [[GABA|gamma-aminobutyric acid]] (GABA).{{citation needed}} Members of this class include [[gabapentin]], [[F-phenibut]], [[phenibut]], [[baclofen]] and [[pregabalin]].
-=See also=
+Gabapentinoids are commonly prescribed for epilepsy, neuropathic pain, and [[restless legs syndrome]]. [[Subjective effects]] include [[sedation]], [[muscle relaxation]], and [[anxiety suppression]].
+Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepines]], [[alcohol]] and [[opioids]].
+==Chemistry==
+Gabapentinoids are 3-substituted derivatives of GABA. Hence, they are GABA analogues, as well as γ-amino acids.<ref>Elaine Wyllie; Gregory D. Cascino; Barry E. Gidal; Howard P. Goodkin (17 February 2012). Wyllie's Treatment of Epilepsy: Principles and Practice. Lippincott Williams & Wilkins. p. 423. ISBN 978-1-4511-5348-4.</ref><ref>Honorio Benzon; James P. Rathmell; Christopher L. Wu; Dennis C. Turk; Charles E. Argoff; Robert W Hurley (11 September 2013). Practical Management of Pain. Elsevier Health Sciences. p. 1006. ISBN 978-0-323-17080-2.</ref>
+==Pharmacology==
+Gabapentinoids act by blocking α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels|channels]] (VGCCs).{{citation needed}} While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.{{citation needed}}
+==Examples==
+*[[Baclofen]]
+*[[F-Phenibut]]
+*[[Gabapentin]]
+*[[Phenibut]]
+*[[Pregabalin]]
+==See also==
 *[[Responsible use]]
 *[[Depressants]]
@@ Line 14: / Line 31: @@
 *[https://en.wikipedia.org/wiki/Gabapentinoid Gabapentinoid (Wikipedia)]
-[[Category:Gabapentinoid]]
+==References==
+[[Category:Gabapentinoid]][[Category:Chemical class]]