Mephedrone: Difference between revisions
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}} {{Stub}} '''Mephedrone''', also known as '''4-methylmethcathinone''' ('''4-MMC''') or '''4-methylephedrone''', is a synthetic stimulant drug of the [[amphetamine]] and [[cathinone]] classes. Slang names include '''drone''',<ref>Mephedrone: Chemistry lessons | http://www.telegraph.co.uk/health/7614099/Mephedrone-Chemistry-lessons.html</ref> '''M-CAT''',<ref>Drugs crackdown hailed a success | http://news.bbc.co.uk/1/hi/scotland/north_east/8555872.stm</ref> and '''meow meow'''.<ref>Mephedrone (4-methylmethcathinone; ‘meow meow’): chemical, pharmacological and clinical issues | http://link.springer.com/article/10.1007%2Fs00213-010-2070-x</ref> It is chemically similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa. It comes in the form of tablets or a powder, which users can swallow, snort, inject or insert rectally producing similar | }} {{Stub}} '''Mephedrone''', also known as '''4-methylmethcathinone''' ('''4-MMC''') or '''4-methylephedrone''', is a synthetic stimulant drug of the [[amphetamine]] and [[cathinone]] classes. Slang names include '''drone''',<ref>Mephedrone: Chemistry lessons | http://www.telegraph.co.uk/health/7614099/Mephedrone-Chemistry-lessons.html</ref> '''M-CAT''',<ref>Drugs crackdown hailed a success | http://news.bbc.co.uk/1/hi/scotland/north_east/8555872.stm</ref> and '''meow meow'''.<ref>Mephedrone (4-methylmethcathinone; ‘meow meow’): chemical, pharmacological and clinical issues | http://link.springer.com/article/10.1007%2Fs00213-010-2070-x</ref> It is chemically similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa. It comes in the form of tablets or a powder, which users can swallow, snort, inject or insert rectally producing effects which are somewhat similar to that [[MDMA]], [[amphetamine]] and [[cocaine]]. | ||
Mephedrone was first synthesised in 1929, but did not become widely known until it was rediscovered in 2003. By 2007, mephedrone was reported to be available for sale on the internet, by 2008 law enforcement agencies had become aware of the compound, and by 2010, it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. | Mephedrone was first synthesised in 1929, but did not become widely known until it was rediscovered in 2003. By 2007, mephedrone was reported to be available for sale on the internet, by 2008 law enforcement agencies had become aware of the compound, and by 2010, it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. | ||
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==Toxicity and Harm Potential== | ==Toxicity and Harm Potential== | ||
Despite similarities to known neurotoxins such as methamphetamine and cathinone derivatives, mephedrone does not appear to produce neurotoxic effects in the dopamine system of mice.<ref>Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum | http://www.ncbi.nlm.nih.gov/pubmed/22191803</ref> | |||
===Lethal dosage=== | ===Lethal dosage=== | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== |