DPT: Difference between revisions

>Dextromethorphan
added binding table from source
>Kenan
m Reverted edits by Natzki (talk) to last revision by Clarity
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{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>
DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>
{| class="wikitable"
|-
! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>
|-
| 5-HT<sub>1A</sub>  || 31.8
|-
| 5-HT<sub>1B</sub>  || 854
|-
| 5-HT<sub>1D</sub>  || 619
|-
| 5-HT<sub>2A</sub> || 2579
|-
| 5-HT<sub>2B</sub> || 42
|-
| 5-HT<sub>2C</sub>  || 1567
|-
| 5-HT<sub>7</sub>  || 284
|-
| α<sub>1B</sub>  || 443
|-
| α<sub>2A</sub>  || 457.6
|-
| α<sub>2B</sub>  || 42
|-
| SERT  || 157
|-
| I<sub>1</sub>  || 340
|-
| σ<sub>1</sub>  || 397
|-
| H<sub>1</sub>  || 125.1
|}


The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
Retrieved from "http://psy.st/wiki/DPT"