DOM: Difference between revisions

Line 20:

DOM is a selective [[agonist|partial agonist]] at the [[Serotonin#The 5-HT System|5-HT2 receptor]] family. Its psychedelic effects are mediated by its [[agonist]]ic properties at the 5-HT2A and 5-HT2B receptors, but less so on the 5-HT2C receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[Serotonin#The 5-HT System|5-HT2 receptor]] subfamily.

~~{| class="wikitable"~~

|-

~~! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>~~

|-

~~| 5-HT1D || 209~~

|-

~~| 5-HT2A || 507~~

|-

~~| 5-HT2B || 11.7~~

|-

~~| 5-HT2C || 3'980~~

|-

~~| β2 || 48.9~~

|}

DOM is a [[Chirality|chiral]] molecule, and ''R''-(-)-DOM is the more active [[enantiomer]], functioning as a potent agonist of the serotonin family of receptors (mainly of the 5-HT2 subtype).<ref>Sanders-Bush, Burris, KD; Knoth, K, (September 1988). "Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis" http://www.ncbi.nlm.nih.gov/pubmed/2843634</ref>

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 {{Further|Serotonergic psychedelic}}
 DOM is a selective [[agonist|partial agonist]] at the [[Serotonin#The 5-HT System|5-HT<sub>2</sub> receptor]] family. Its psychedelic effects are mediated by its [[agonist]]ic properties at the 5-HT<sub>2A</sub> and 5-HT<sub>2B</sub> receptors, but less so on the 5-HT<sub>2C</sub> receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[Serotonin#The 5-HT System|5-HT<sub>2</sub> receptor]] subfamily.
-{| class="wikitable"
-|-
-! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>
-|-
-| 5-HT<sub>1D</sub>  || 209
-|-
-| 5-HT<sub>2A</sub> || 507
-|-
-| 5-HT<sub>2B</sub> || 11.7
-|-
-| 5-HT<sub>2C</sub>  || 3'980
-|-
-| β<sub>2</sub>  || 48.9
-|}
 DOM is a [[Chirality|chiral]] molecule, and ''R''-(-)-DOM is the more active [[enantiomer]], functioning as a potent agonist of the serotonin family of receptors (mainly of the 5-HT<sub>2</sub> subtype).<ref>Sanders-Bush, Burris, KD; Knoth, K, (September 1988). "Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis" http://www.ncbi.nlm.nih.gov/pubmed/2843634</ref>