DOM: Difference between revisions

Line 19:

==Pharmacology==

DOM is a selective [[Serotonin#The 5-HT System|5-HT2A]], [[~~Serotonin#The 5-HT System|~~5-HT2B~~]],~~ and ~~[[Serotonin#The 5-HT System|~~5-HT2C ~~receptor]] [[agonist|partial agonist]]. Its psychedelic effects are mediated by its [[agonist]]ic properties at~~ the 5-HT2A receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[Serotonin#The 5-HT System|5-HT2 receptor]] subfamily.

DOM is a selective [[agonist|partial agonist]] at the [[Serotonin#The 5-HT System|5-HT2 receptor]] family. Its psychedelic effects are mediated by its [[agonist]]ic properties at the 5-HT2A and 5-HT2B receptors, but less so on the 5-HT2C receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[Serotonin#The 5-HT System|5-HT2 receptor]] subfamily.

{| class="wikitable"

|-

! Site !! Binding Affinity (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>

|-

| 5-HT2A || 507

|-

| 5-HT2B || 11.7

|-

| 5-HT2C || 3'980

|-

| 5-HT1D || 209

|-

| β2 || 48.9

|}

DOM is a [[Chirality|chiral]] molecule, and ''R''-(-)-DOM is the more active [[enantiomer]], functioning as a potent agonist of the serotonin family of receptors (mainly of the 5-HT2 subtype).<ref>Sanders-Bush, Burris, KD; Knoth, K, (September 1988). "Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis" http://www.ncbi.nlm.nih.gov/pubmed/2843634</ref>

@@ Line 19: / Line 19: @@
 ==Pharmacology==
 {{Further|Serotonergic psychedelic}}
-DOM is a selective [[Serotonin#The 5-HT System|5-HT<sub>2A</sub>]], [[Serotonin#The 5-HT System|5-HT<sub>2B</sub>]], and [[Serotonin#The 5-HT System|5-HT<sub>2C</sub> receptor]] [[agonist|partial agonist]]. Its psychedelic effects are mediated by its [[agonist]]ic properties at the 5-HT<sub>2A</sub> receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[Serotonin#The 5-HT System|5-HT<sub>2</sub> receptor]] subfamily.
+DOM is a selective [[agonist|partial agonist]] at the [[Serotonin#The 5-HT System|5-HT<sub>2</sub> receptor]] family. Its psychedelic effects are mediated by its [[agonist]]ic properties at the 5-HT<sub>2A</sub> and 5-HT<sub>2B</sub> receptors, but less so on the 5-HT<sub>2C</sub> receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[Serotonin#The 5-HT System|5-HT<sub>2</sub> receptor]] subfamily.
+{| class="wikitable"
+|-
+! Site !! Binding Affinity (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>
+|-
+| 5-HT<sub>2A</sub> || 507
+|-
+| 5-HT<sub>2B</sub> || 11.7
+|-
+| 5-HT<sub>2C</sub>  || 3'980
+|-
+| 5-HT<sub>1D</sub>  || 209
+|-
+| β<sub>2</sub>  || 48.9
+|}
 DOM is a [[Chirality|chiral]] molecule, and ''R''-(-)-DOM is the more active [[enantiomer]], functioning as a potent agonist of the serotonin family of receptors (mainly of the 5-HT<sub>2</sub> subtype).<ref>Sanders-Bush, Burris, KD; Knoth, K, (September 1988). "Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis" http://www.ncbi.nlm.nih.gov/pubmed/2843634</ref>