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2C-E: Difference between revisions
>Kenan m Use psychedelics template |
>Dextromethorphan added most important binding affinities |
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{{pharmacology}} | {{pharmacology}} | ||
{{Further|Serotonergic psychedelic}} | {{Further|Serotonergic psychedelic}} | ||
2C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub> | 2C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2</sub> receptor]] family as a [[Agonist#Agonists|partial agonist]]. | ||
{| class="wikitable" | |||
|- | |||
! Site !! Binding Affinity (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref> | |||
|- | |||
| 5-HT<sub>2A</sub> || 43.9 | |||
|- | |||
| 5-HT<sub>2B</sub> || 25.1 | |||
|- | |||
| 5-HT<sub>2C</sub> || 104.1 | |||
|- | |||
| 5-HT<sub>1A</sub> || 307 | |||
|- | |||
| 5-HT<sub>1B</sub> || 253 | |||
|- | |||
| 5-HT<sub>1D</sub> || 73.2 | |||
|- | |||
| 5-HT<sub>1E</sub> || 626 | |||
|- | |||
| α<sub>2C</sub> || 90.2 | |||
|} | |||
The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation. | |||
==Subjective effects== | ==Subjective effects== | ||
{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||