DOC: Difference between revisions

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===Overdose===

~~Overdose on~~ DOC ~~can start~~ past the heavy dose range, although sensitive~~, inexperienced people can of course~~ overdose at doses lower than these. ~~Routes other than~~ oral also seem to exhibit a higher chance of overdosing ~~due~~ to ~~greater~~ bioavailability, potency and unpredictability of dosage and effects. Overdose effects typically include bizzare, [[delusion]]al and sometimes violent behavior, [[amnesia]], [[tactile suppression|numbness]], [[confusion]] and [[anxiety]]. The ~~person~~ may not be able to communicate and can be severely agitated. At appropriately high doses, more serious side effects include [[panic attack]]s, [[seizures]], dangerously [[increased heart rate|elevated heart rate]], [[increased blood pressure|blood pressure]] and [[vasoconstriction]]{{citation needed}}. Severe vasoconstriction typically develops to its peak several hours into the intoxication and may need medical ~~assistence~~ if blood flow is cut off ~~significantly~~. If overdose ~~occurs~~, [[benzodiazepines]] ~~should~~ be ~~taken if possible~~ to ~~kill~~ the hyperagitative effects~~, and a~~ powerful vasodilator may need to be administered ~~via the hospital,~~ to prevent a hypertensive emergency, ~~gangrene~~ or in more serious cases, organ failure and death from the resulting hypoxia. ~~DOC seems to exhibit its toxicity mostly in the brain in the form of memory problems~~{{citation needed}} ~~and [[HPPD]] as well as on~~ the ~~circulatory system{{citation needed}}. The LD50 for~~ DOC ~~is unknown~~.

The risk of DOC overdose is present starting in or past the heavy dose range, although sensitive users may overdose at doses lower than these. Non-oral routes also seem to exhibit a higher chance of overdosing, perhaps owing to differences in bioavailability, potency and unpredictability of dosage and effects. Overdose effects typically include bizzare, [[delusion|delusional]] and sometimes violent behavior, [[amnesia]], [[tactile suppression|numbness]], [[confusion]] and [[anxiety]]. The user may not be able to communicate and can be severely agitated. At appropriately high doses, more serious side effects include [[panic attack]]s, [[seizures]], dangerously [[increased heart rate|elevated heart rate]], [[increased blood pressure|blood pressure]] and [[vasoconstriction]].{{citation needed}} Severe vasoconstriction typically develops to its peak several hours into the intoxication and may need medical assistance if blood flow is significantly cut off for extended periods of time.

In the event of an overdose, [[benzodiazepines]] can be administered to mitigate the hyperagitative effects.{{citation needed}} A powerful vasodilator may also need to be administered to prevent a hypertensive emergency, or in more serious cases, necrosis, organ failure and death from the resulting hypoxia.{{citation needed}} As a result, emergency medical services should always be sought in the event of a DOC overdose.

===Tolerance and addiction potential===

@@ Line 148: / Line 148: @@
 ===Overdose===
-Overdose on DOC can start past the heavy dose range, although sensitive, inexperienced people can of course overdose at doses lower than these. Routes other than oral also seem to exhibit a higher chance of overdosing due to greater bioavailability, potency and unpredictability of dosage and effects. Overdose effects typically include bizzare, [[delusion]]al and sometimes violent behavior, [[amnesia]], [[tactile suppression|numbness]], [[confusion]] and [[anxiety]]. The person may not be able to communicate and can be severely agitated. At appropriately high doses, more serious side effects include [[panic attack]]s, [[seizures]], dangerously [[increased heart rate|elevated heart rate]], [[increased blood pressure|blood pressure]] and [[vasoconstriction]]{{citation needed}}. Severe vasoconstriction typically develops to its peak several hours into the intoxication and may need medical assistence if blood flow is cut off significantly. If overdose occurs, [[benzodiazepines]] should be taken if possible to kill the hyperagitative effects, and a powerful vasodilator may need to be administered via the hospital, to prevent a hypertensive emergency, gangrene or in more serious cases, organ failure and death from the resulting hypoxia. DOC seems to exhibit its toxicity mostly in the brain in the form of memory problems{{citation needed}} and [[HPPD]] as well as on the circulatory system{{citation needed}}. The LD50 for DOC is unknown.
+The risk of DOC overdose is present starting in or past the heavy dose range, although sensitive users may overdose at doses lower than these. Non-oral routes also seem to exhibit a higher chance of overdosing, perhaps owing to differences in bioavailability, potency and unpredictability of dosage and effects. Overdose effects typically include bizzare, [[delusion|delusional]] and sometimes violent behavior, [[amnesia]], [[tactile suppression|numbness]], [[confusion]] and [[anxiety]]. The user may not be able to communicate and can be severely agitated. At appropriately high doses, more serious side effects include [[panic attack]]s, [[seizures]], dangerously [[increased heart rate|elevated heart rate]], [[increased blood pressure|blood pressure]] and [[vasoconstriction]].{{citation needed}} Severe vasoconstriction typically develops to its peak several hours into the intoxication and may need medical assistance if blood flow is significantly cut off for extended periods of time.
+In the event of an overdose, [[benzodiazepines]] can be administered to mitigate the hyperagitative effects.{{citation needed}} A powerful vasodilator may also need to be administered to prevent a hypertensive emergency, or in more serious cases, necrosis, organ failure and death from the resulting hypoxia.{{citation needed}} As a result, emergency medical services should always be sought in the event of a DOC overdose.
 ===Tolerance and addiction potential===