LSA: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
LSA acts as a [[Serotonin#The_5-HT_System|5-HT<sub>1A</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>2A</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>2B</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>2C</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>5</sub>]] and [[Serotonin#The_5-HT_System|5-HT<sub>6</sub>]] [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from LSA's efficacy at the [[Serotonin#The_5-HT_System|5-HT<sub>2A</sub>]] receptors.<ref>COMPARATIVE STUDY ON THE SEROTONIN ANTAGONISM OF AMIDE DERIVATIVES OF LYSERGIC ACID AND OF ERGOT ALKALOIDS | http://jpet.aspetjournals.org/content/122/1/124.short</ref> There is also efficacy at all [[Dopamine#The Dopamine System|dopamine receptors]] and all [[Adrenaline#The_Adrenergic_System|adrenoreceptors]]. <ref>http://molpharm.aspetjournals.org/content/12/4/631.short</ref> | LSA acts as a [[Serotonin#The_5-HT_System|5-HT<sub>1A</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>2A</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>2B</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>2C</sub>]], [[Serotonin#The_5-HT_System|5-HT<sub>5</sub>]] and [[Serotonin#The_5-HT_System|5-HT<sub>6</sub>]] [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from LSA's efficacy at the [[Serotonin#The_5-HT_System|5-HT<sub>2A</sub>]] receptors.<ref>COMPARATIVE STUDY ON THE SEROTONIN ANTAGONISM OF AMIDE DERIVATIVES OF LYSERGIC ACID AND OF ERGOT ALKALOIDS | http://jpet.aspetjournals.org/content/122/1/124.short</ref> There is also efficacy at all [[Dopamine#The Dopamine System|dopamine receptors]] and all [[Adrenaline#The_Adrenergic_System|adrenoreceptors]].<ref>http://molpharm.aspetjournals.org/content/12/4/631.short</ref> | ||
==Subjective effects== | ==Subjective effects== | ||
===[[Physical effects - Psychedelics|Physical effects]]=== | ===[[Physical effects - Psychedelics|Physical effects]]=== | ||
The physical effects of LSA can be broken down into | The physical effects of LSA can be broken down into three components all of which progressively intensify proportional to dosage. These are described below and generally include: | ||
*'''[[Physical effects: Spontaneous tactile sensations|Spontaneous tactile sensations]]''' - | *'''[[Physical effects: Spontaneous tactile sensations|Spontaneous tactile sensations]]''' - The body high of LSA can be described as a mild yet pleasurable, soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of [[Physical effects: Euphoria|physical euphoria]] which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. In either case, they steadily rise with the onset and hit their limit once the peak has been reached. | ||
*'''[[Physical effects: Sedation|Sedation]]''' - | *'''[[Physical effects: Sedation|Sedation]]''' - In terms of its effects on the physical energy levels of the tripper, LSA tends to be sedating, however, it can be setting dependent. For example, when taken in settings with large amounts of stimulus or during physically strenuous activities such as walking, running, climbing or dancing it is fully capable of becoming stimulating and energetic. In contrast, however, when taken in calm environments such as darkened rooms with comfortable seating it is consistently relaxing, peaceful and quite sedating. | ||
*'''[[Physical effects: Vasoconstriction|Vasoconstriction]]''' | *'''[[Physical effects: Vasoconstriction|Vasoconstriction]]''' | ||
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===[[Visual effects - Psychedelics|Visual effects]]=== | ===[[Visual effects - Psychedelics|Visual effects]]=== | ||
The visual effects of LSA are mostly present when large doses have been consumed and proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects when compared to substances such as [[LSD]] and [[psilocin]]. | The visual effects of LSA are mostly present when large doses have been consumed and proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects when compared to substances such as [[LSD]] and [[psilocin]]. | ||
====[[Visual effects | ====[[Visual effects: Enhancements|Enhancements|Enhancements]]==== | ||
LSA presents a full and complete array of potential visual enhancements which generally includes: | LSA presents a full and complete array of potential visual enhancements which generally includes: | ||
*'''[[Visual effects: Increased visual acuity|Increased visual acuity]]''' | *'''[[Visual effects: Increased visual acuity|Increased visual acuity]]''' | ||
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*'''[[Visual effects: Enhanced pattern recognition|Enhanced pattern recognition]]''' | *'''[[Visual effects: Enhanced pattern recognition|Enhanced pattern recognition]]''' | ||
====[[Visual effects | ====[[Visual effects: Distortions (psychedelic)|Distortions]]==== | ||
As for visual distortions and alterations, these are significantly more simplistic from that of open eye distortions found with other psychedelics. Effects experienced are detailed below: | As for visual distortions and alterations, these are significantly more simplistic from that of open eye distortions found with other [[psychedelics]]. Effects experienced are detailed below: | ||
*'''[[Visual effects: Drifting|Drifting]]''' ''([[Visual effects | *'''[[Visual effects: Drifting|Drifting]]''' ''([[Visual effects: Drifting#Melting|Melting]], [[Visual effects: Drifting#Breathing|Breathing]], [[Visual effects: Drifting#Morphing|Morphing]] and [[Visual effects: Drifting#Flowing|Flowing]])'' - In comparison to other psychedelics this effect can be described as mild but highly detailed yet cartoon like in appearance. They are fast yet smooth in motion and fleeting in their permanence. This is an inconsistently manifested effect with some never reporting such effects. | ||
*'''[[Visual effects: Colour shifting|Colour shifting]]''' | *'''[[Visual effects: Colour shifting|Colour shifting]]''' | ||
====[[Visual effects | ====[[Visual effects: Geometry (psychedelic)|Geometry]]==== | ||
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[Psilocetin|4-AcO-DMT]], [[Ayahuasca]] and [[2C-E]] than [[LSD]] or [[2C-B]]. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, zoomed out and small in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a much more "natural" feel to them than [[LSD]] and at higher dosages are significantly more likely to result in states of [[Visual effects - Psychedelics#7B - Exposure to inner mechanics of human consciousness|Level 7B]] | The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[Psilocetin|4-AcO-DMT]], [[Ayahuasca]] and [[2C-E]] than [[LSD]] or [[2C-B]]. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, zoomed out and small in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a much more "natural" feel to them than [[LSD]] and at higher dosages are significantly more likely to result in states of [[Visual effects - Psychedelics#7B - Exposure to inner mechanics of human consciousness|Level 7B]] geometry over [[Visual effects - Psychedelics#7A - Exposure to entirety of neurological structure|Level 7A]]. | ||
===[[Visual effects - Psychedelics#Hallucinatory States|Hallucinatory states]]=== | ===[[Visual effects - Psychedelics#Hallucinatory States|Hallucinatory states]]=== | ||
LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses. The effects of such states include, | LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses. The effects of such states include, | ||
*'''[[Visual effects: External hallucinations (psychedelic)|External hallucinations]]''' - | *'''[[Visual effects: External hallucinations (psychedelic)|External hallucinations (psychedelic)]]''' - These are extremely common within LSA and partially follow the content of the user's current thought process. | ||
*'''[[Visual effects: Internal hallucinations (psychedelic)|Internal hallucinations]]''' - | *'''[[Visual effects: Internal hallucinations (psychedelic)|Internal hallucinations (psychedelic)]]''' - Unlike [[LSD]], LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a [[Portal:Lucid Dreaming|lucid dream]] state and commonly contains hallucinations with plots, settings, autonomous entity contact and scenarios. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme. These hallucinations are complemented by a powerful enhancement of ones ability to visualize concepts. This ability eventually becomes so drawn out proportional to dosage that it leads to full blown hallucinatory states that are entirely lucid and for the most part controllable. | ||
==[[Auditory effects - Psychedelics|Auditory effects]]== | ==[[Auditory effects - Psychedelics|Auditory effects]]== | ||
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*'''[[Auditory effects: Hallucinations|Hallucinations]]''' | *'''[[Auditory effects: Hallucinations|Hallucinations]]''' | ||
= | =Forms= | ||
===Morning glory seeds=== | ===Morning glory seeds=== | ||
[[File:Lsa_-_morning_glory_seedsgck.jpg|thumb|right|upright|200px|Morning glory seeds.]] | [[File:Lsa_-_morning_glory_seedsgck.jpg|thumb|right|upright|200px|Morning glory seeds.]] | ||
The seeds of many species of morning glory contain [[lysergamides|lysergamide]] [[alkaloid]]s such as the [[psychedelics|psychedelic]] known as LSA.<ref>http://jama.jamanetwork.com/article.aspx?articleid=1165951</ref> | The seeds of many species of morning glory contain [[lysergamides|lysergamide]] [[alkaloid]]s such as the [[psychedelics|psychedelic]] known as LSA.<ref>http://jama.jamanetwork.com/article.aspx?articleid=1165951</ref> Though the chemical LSA is not legal in some countries, the seeds are found in many gardening stores; however, it's worth noting that the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. Seeds without these pesticides can be purchased cheaply online and are freely available. | ||
When using morning glory seeds the dosage for oral consumption is generally considered to be: | When using morning glory seeds the dosage for oral consumption is generally considered to be: | ||
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===Hawaiian baby woodrose seeds=== | ===Hawaiian baby woodrose seeds=== | ||
[[File:Hawaiin_baby_woodrose.jpg|thumb|right|upright|200px|Hawaiian baby woodrose seeds.]] | [[File:Hawaiin_baby_woodrose.jpg|thumb|right|upright|200px|Hawaiian baby woodrose seeds.]] | ||
Hawaiian baby woodrose is a perennial climbing vine that is native to the Indian subcontinent and introduced to numerous areas worldwide, including Hawaii, Africa and the Caribbean. Hawaiian Baby Woodrose seeds may be consumed for their various [[lysergamides|lysergamide]] alkaloids, such as LSA.<ref>http://www.sciencedirect.com/science/article/pii/S0379073809004745</ref> Although the chemical LSA is not legal in some countries, the seeds are found in many gardening stores; however, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. Seeds without these pesticides can be purchased cheaply online and are freely available | Hawaiian baby woodrose is a perennial climbing vine that is native to the Indian subcontinent and introduced to numerous areas worldwide, including Hawaii, Africa and the Caribbean. Hawaiian Baby Woodrose seeds may be consumed for their various [[lysergamides|lysergamide]] alkaloids, such as LSA.<ref>http://www.sciencedirect.com/science/article/pii/S0379073809004745</ref> Although the chemical LSA is not legal in some countries, the seeds are found in many gardening stores; however, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. Seeds without these pesticides can be purchased cheaply online and are freely available. | ||
When using Hawaiian Baby Woodrose seeds the dosage for oral consumption is generally considered to be: | When using Hawaiian Baby Woodrose seeds the dosage for oral consumption is generally considered to be: | ||
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*'''Strong :''' ''7 - 12 seeds'' | *'''Strong :''' ''7 - 12 seeds'' | ||
*'''Heavy :''' ''12 + seeds'' | *'''Heavy :''' ''12 + seeds'' | ||
=Toxicity and Harm Potential= | |||
===Vasoconstriction=== | |||
LSA should not be used nonstop. When used repeatedly over a short period of time the vasoconstriction effects build up while the psychoactive effects get weaker. If you’re feeling sore legs, this is a sign of the vasoconstriction effects building up in your body.<ref>http://www.ncbi.nlm.nih.gov/pubmed/11128853</ref> The legs feel sore because not enough blood is getting to the muscles. The upper leg muscles are the largest, most energy consuming muscles in the body, and they will feel sore if blood flow to them is lowered even slightly. If you’ve taken HBWR seeds, morning glory seeds or pure LSA and are experiencing sore legs a well needed break is completely necessary. With LSA it can take up to 3 days of abstinence to get back to vasoconstriction baseline. <ref>http://animalsci.highwire.org/content/84/11/3167.short</ref> | |||
===Lethal Dosage=== | |||
The LD<sub>50</sub> of LSA for human beings has never been reached in any setting, but is thought to be incredibly high, similar to [[LSD]]. There are not any known deaths associated directly with pharmacological causes of LSA, but rather due to self-harm, impaired judgement, and drug interactions. | |||
===Tolerance and Addiction Potential=== | |||
LSA is non-habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating. | |||
An almost immediate tolerance is built to LSA after ingestion, preventing one from experiencing its full effects more often than every 4-7 days, unless they increase their dose significantly. | |||
=Legal issues= | =Legal issues= |