Selective serotonin reuptake inhibitor: Difference between revisions

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Most SSRIs inhibit the function of certain cytochrome P450 enzymes that metabolize other substances so that SSRIs may lead to an increased or decreased serum level of certain medications.

===~~Hallucination suppression~~===

===Combinations===

*'''[[Psychedelics]]''' - Due do the downregulation of 5-HT<sub>2A</sub> receptors caused by SSRIs, psychedelics can have a reduced effect. SSRIs can also reduce the chance of having a [[bad trip]] due to its [[Anxiety suppression|anxiolytic]] effects.

*'''[[Cannabis]]''' - While on SSRIs, the [[anxiety]] and [[paranoia]] experienced on cannabis may be less intense, or not experienced at all.

*'''[[Depressants]]''' - SSRIs increase the effects of CNS [[depressants]] such as [[alcohol]], [[opioids]], and [[benzodiazepines]]. This effect is sometimes not desired as it may intensify [[disinhibition]] and increase the chance of having a blackout.

~~While on~~ SSRI's, ~~classical~~ [[~~psychedelics~~]] and [[~~dissociatives~~]] are ~~commonly reported~~ to ~~show very little or no visual effects~~.

===Dangerous interactions===

*'''[[Dextromethorphan]]''' - Dextromethorphan is a serotonin releaser as well as an SSRI, therefore has a potential to cause [[serotonin syndrome]], a potentially deadly condition caused by extremely high serotonin levels. Although serotonin syndrome caused by this combination is uncommon, it is strongly advised not to combine them, especially if either is at a high dose.

*'''[[Empathogens]]''' - Combining SSRIs with serotonergic empathogens such as [[MDMA]], [[mephedrome]], and AMT can result in [[serotonin syndrome]].

*'''[[Tramadol]]''' - Combining SSRIs with tramadol can result in [[serotonin syndrome]].

*'''Other antidepresants''' - Combining SSRIs with other antidepressants such as tricyclic antidepressants and [[MAOI|MAOIs]] can result in [[serotonin syndrome]]. Non serotonergic antidepressants such as [[bupropion]] are not dangerous to combine with SSRIs.

==See also==

@@ Line 86: / Line 86: @@
 Most SSRIs inhibit the function of certain cytochrome P450 enzymes that metabolize other substances so that SSRIs may lead to an increased or decreased serum level of certain medications.
-===Hallucination suppression===
+===Combinations===
+*'''[[Psychedelics]]''' - Due do the downregulation of 5-HT<sub>2A</sub> receptors caused by SSRIs, psychedelics can have a reduced effect. SSRIs can also reduce the chance of having a [[bad trip]] due to its [[Anxiety suppression|anxiolytic]] effects.
+*'''[[Cannabis]]''' - While on SSRIs, the [[anxiety]] and [[paranoia]] experienced on cannabis may be less intense, or not experienced at all.
+*'''[[Depressants]]''' - SSRIs increase the effects of CNS [[depressants]] such as [[alcohol]], [[opioids]], and [[benzodiazepines]]. This effect is sometimes not desired as it may intensify [[disinhibition]] and increase the chance of having a blackout.
-While on SSRI's, classical [[psychedelics]] and [[dissociatives]] are commonly reported to show very little or no visual effects.
+===Dangerous interactions===
+*'''[[Dextromethorphan]]''' - Dextromethorphan is a serotonin releaser as well as an SSRI, therefore has a potential to cause [[serotonin syndrome]], a potentially deadly condition caused by extremely high serotonin levels. Although serotonin syndrome caused by this combination is uncommon, it is strongly advised not to combine them, especially if either is at a high dose.
+*'''[[Empathogens]]''' - Combining SSRIs with serotonergic empathogens such as [[MDMA]], [[mephedrome]], and AMT can result in [[serotonin syndrome]].
+*'''[[Tramadol]]''' - Combining SSRIs with tramadol can result in [[serotonin syndrome]].
+*'''Other antidepresants''' - Combining SSRIs with other antidepressants such as tricyclic antidepressants and [[MAOI|MAOIs]] can result in [[serotonin syndrome]]. Non serotonergic antidepressants such as [[bupropion]] are not dangerous to combine with SSRIs.
 ==See also==