4-HO-MPT: Difference between revisions

(22 intermediate revisions by 9 users not shown)

Line 2:

'''4-Hydroxy-N-methyl-N-propyltryptamine''' (also known as '''4-HO-MPT''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is a closely related structural analog of [[4-HO-DMT]] (''Psilocin'') and other hallucinogenic tryptamines with powerful psychedelic effects.

'''4-Hydroxy-N-methyl-N-propyltryptamine''' (also known as '''4-HO-MPT''' or '''Meprocin''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is a closely related structural analog of [[4-HO-DMT]] (''Psilocin'') and other hallucinogenic tryptamines with powerful psychedelic effects.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. It has ~~no history of human use before being~~ sold online as a [[research chemical]] in 2016.{{citation needed}} It ~~is obscure~~ and ~~is either used recreationally or for research purposes~~.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. It has been sold online as a [[research chemical]] as of 2016.{{citation needed}} It was synthesised and described by Alexander Shulgin in his 1994 book TiHKAL.<ref name="TiHKAL">{{cite book|title=TiHKAL: The Continuation|title-link=TiHKAL|last1=Shulgin|first1=Alexander|last2=Shulgin|first2=Ann|author-link1=Alexander Shulgin|year=1997|publisher=Transform Press|location=United States|isbn=0-9630096-9-9|oclc=38503252|chapter-url=https://erowid.org/library/books_online/tihkal/tihkal23.shtml|chapter=#23. 4-HO-MPT}}</ref>

==Chemistry==

Line 11:

==Pharmacology==

4-HO-MPT is a psychedelic drug in the [[Tryptamines|tryptamine]] class of chemical compounds and is a higher homologue of the naturally occurring substituted tryptamine [[psilocin]] as well as being the 4-hydroxyl analog of [[MPT]].<ref>https://www.erowid.org/library/books_online/tihkal/tihkal23.shtml</ref>

Like with most [[psychedelic]] tryptamines, 4-HO-MPT is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-HO-MPT's binding efficacy at the 5-HT<sub>2A</sub> receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Line 46:

Line 48:

====Hallucinatory states====

*'''[[Effect::Transformations]]'''

*'''[[Effect::Internal ~~hallucinations~~]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::~~alterations in~~ perspective]]'' and ''[[effect::scenarios and plots]]'')

*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')

}}

Line 52:

Line 54:

*'''[[Effect::Conceptual thinking]]'''

*'''[[Effect::Cognitive euphoria]]'''

*'''[[Effect::~~Delusions~~]]'''

*'''[[Effect::Delusion]]'''

*'''[[Effect::Emotion enhancement]]'''

*'''[[Effect::Immersion enhancement]]'''

Line 75:

Line 77:

}}

===Experience reports===

Anecdotal reports which describe the effects of this compound within our [[experience index]] include:

{{#ask: [[Category:4-HO-MPT]][[Category:Experience]]|format=ul|Columns=2}}

Additional experience reports can be found here:

*[https://erowid.org/experiences/subs/exp_4HOMPT.shtml Erowid Experience Vaults: 4-HO-MPT]

==Toxicity and harm potential==

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

Line 84:

Line 93:

===Tolerance and addiction potential===

4-HO-MPT is generally considered [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.

4-HO-MPT is generally considered [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.

Tolerance to the effects of 4-HO-MPT ~~are~~ built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MPT all psychedelics will have a reduced effect.

Tolerance to the effects of 4-HO-MPT is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MPT all psychedelics will have a reduced effect.

==~~Legality~~==

===Dangerous interactions===

==Legal status==

Due to its relative obscurity, the possession and sale of 4-HO-MPT is unscheduled in most countries.

*'''United Kingdom:''' 4-HO-MPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>~~Misuse of~~ Drugs ~~Act 1971 (Legislation.gov.uk)~~ |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I~~#reference~~-~~M_F_c7632653-ddad-4420-f307-e3da1e36d30e~~</ref>

*'''Germany''': 4-HO-MPT is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MPT are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>

*'''United States:''' 4-HO-MPT is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}

*'''Switzerland''': 4-HO-MPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''United Kingdom''': 4-HO-MPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>

*'''United States''': 4-HO-MPT is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}

==See also==

*[[Responsible use]]

*[[Research chemical]]

Line 104:

Line 120:

==External links==

*[https://en.wikipedia.org/wiki/4-HO-MPT 4-HO-MPT (Wikipedia)]

*[https://erowid.org/chemicals/4_ho_mpt/4_ho_mpt.shtml 4-HO-MPT (Erowid Vault)]

*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=23 4-HO-MPT (TiHKAL / Isomer Design)]

*[http://www.bluelight.org/vb/threads/550416-The-Big-amp-Dandy-4-HO-MPT-Thread The Big & Dandy 4-HO-MPT Thread (Bluelight)]

==References==

[[Category:Substance]]

[[Category:Psychoactive substance]]

[[Category:~~Research chemical~~]]

[[Category:Hallucinogen]]

[[Category:Psychedelic]]

[[Category:Tryptamine]]

[[Category:Research chemical]]

@@ Line 2: / Line 2: @@
 {{SubstanceBox/4-HO-MPT}}
-'''4-Hydroxy-N-methyl-N-propyltryptamine''' (also known as '''4-HO-MPT''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is a closely related structural analog of [[4-HO-DMT]] (''Psilocin'') and other hallucinogenic tryptamines with powerful psychedelic effects.
+'''4-Hydroxy-N-methyl-N-propyltryptamine''' (also known as '''4-HO-MPT''' or '''Meprocin''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is a closely related structural analog of [[4-HO-DMT]] (''Psilocin'') and other hallucinogenic tryptamines with powerful psychedelic effects.
-Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. It has no history of human use before being sold online as a [[research chemical]] in 2016.{{citation needed}} It is obscure and is either used recreationally or for research purposes.
+Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. It has been sold online as a [[research chemical]] as of 2016.{{citation needed}} It was synthesised and described by Alexander Shulgin in his 1994 book TiHKAL.<ref name="TiHKAL">{{cite book|title=TiHKAL: The Continuation|title-link=TiHKAL|last1=Shulgin|first1=Alexander|last2=Shulgin|first2=Ann|author-link1=Alexander Shulgin|year=1997|publisher=Transform Press|location=United States|isbn=0-9630096-9-9|oclc=38503252|chapter-url=https://erowid.org/library/books_online/tihkal/tihkal23.shtml|chapter=#23. 4-HO-MPT}}</ref>
 ==Chemistry==
@@ Line 11: / Line 11: @@
 ==Pharmacology==
 {{Further|Serotonergic psychedelic}}
+-HO-MPT is a psychedelic drug in the [[Tryptamines|tryptamine]] class of chemical compounds and is a higher homologue of the naturally occurring substituted tryptamine [[psilocin]] as well as being the 4-hydroxyl analog of [[MPT]].<ref>https://www.erowid.org/library/books_online/tihkal/tihkal23.shtml</ref>
 Like with most [[psychedelic]] tryptamines, 4-HO-MPT is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-HO-MPT's binding efficacy at the 5-HT<sub>2A</sub> receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
@@ Line 46: / Line 48: @@
 ====Hallucinatory states====
 *'''[[Effect::Transformations]]'''
-*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
+*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
 }}
@@ Line 52: / Line 54: @@
 *'''[[Effect::Conceptual thinking]]'''
 *'''[[Effect::Cognitive euphoria]]'''
-*'''[[Effect::Delusions]]'''
+*'''[[Effect::Delusion]]'''
 *'''[[Effect::Emotion enhancement]]'''
 *'''[[Effect::Immersion enhancement]]'''
@@ Line 75: / Line 77: @@
 }}
 }}
+===Experience reports===
+Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
+{{#ask: [[Category:4-HO-MPT]][[Category:Experience]]|format=ul|Columns=2}}
+Additional experience reports can be found here:
+*[https://erowid.org/experiences/subs/exp_4HOMPT.shtml Erowid Experience Vaults: 4-HO-MPT]
 ==Toxicity and harm potential==
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
@@ Line 84: / Line 93: @@
 ===Tolerance and addiction potential===
--HO-MPT is generally considered [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.
+-HO-MPT is generally considered [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.
-Tolerance to the effects of 4-HO-MPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MPT all psychedelics will have a reduced effect.
+Tolerance to the effects of 4-HO-MPT is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MPT all psychedelics will have a reduced effect.
-==Legality==
+===Dangerous interactions===
+{{DangerousInteractions/Intro}}
+{{DangerousInteractions/Psychedelics}}
+==Legal status==
 Due to its relative obscurity, the possession and sale of 4-HO-MPT is unscheduled in most countries.
-*'''United Kingdom:''' 4-HO-MPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e</ref>
+*'''Germany''': 4-HO-MPT is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MPT are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
-*'''United States:''' 4-HO-MPT is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
+*'''Switzerland''': 4-HO-MPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
+*'''United Kingdom''': 4-HO-MPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
+*'''United States''': 4-HO-MPT is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
 ==See also==
 *[[Responsible use]]
 *[[Research chemical]]
@@ Line 104: / Line 120: @@
 ==External links==
+*[https://en.wikipedia.org/wiki/4-HO-MPT 4-HO-MPT (Wikipedia)]
+*[https://erowid.org/chemicals/4_ho_mpt/4_ho_mpt.shtml 4-HO-MPT (Erowid Vault)]
+*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=23 4-HO-MPT (TiHKAL / Isomer Design)]
 *[http://www.bluelight.org/vb/threads/550416-The-Big-amp-Dandy-4-HO-MPT-Thread The Big & Dandy 4-HO-MPT Thread (Bluelight)]
 ==References==
-<references/>
+<references />
+[[Category:Substance]]
 [[Category:Psychoactive substance]]
-[[Category:Research chemical]]
+[[Category:Hallucinogen]]
 [[Category:Psychedelic]]
 [[Category:Tryptamine]]
+[[Category:Research chemical]]
 {{#set:Featured=true}}