This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
User:Oskykins/More writings and notes (talk): Difference between revisions
>Surgeon m Diogenes moved page Talk:More writings and notes (oscarette) to User:Oscarette/More writings and notes (talk) without leaving a redirect |
>Oskykins m Text replacement - "oscarette" to "oskykins" |
||
| (3 intermediate revisions by 2 users not shown) | |||
| Line 17: | Line 17: | ||
*[[Psilocetin]] (4-AcO-DMT) | *[[Psilocetin]] (4-AcO-DMT) | ||
*[[AMT]] | *[[AMT]] | ||
*[[5-MeO- | *[[5-MeO-MiPT]] | ||
*[[MDMA]] | *[[MDMA]] | ||
*[[DOC]] | *[[DOC]] | ||
| Line 42: | Line 42: | ||
2014-03-29 21:43:53 lolwut|PJosepherum but i realised today that inhibiting MAOs is a really dirty hack | 2014-03-29 21:43:53 lolwut|PJosepherum but i realised today that inhibiting MAOs is a really dirty hack | ||
2014-03-29 21:44:01 @ | 2014-03-29 21:44:01 @oskykins what do you mean? | ||
2014-03-29 21:44:04 -- lolwut|PJosepherum is now known as PJosepherum | 2014-03-29 21:44:04 -- lolwut|PJosepherum is now known as PJosepherum | ||
2014-03-29 21:45:52 PJosepherum MAO-A and -B break down monamines; this includes alkaloids like dmt, nicotine, ethanol, opioids, etc, but also includes endogenous hormones. because the chemicals are not being inactivated, they build up in the axons | 2014-03-29 21:45:52 PJosepherum MAO-A and -B break down monamines; this includes alkaloids like dmt, nicotine, ethanol, opioids, etc, but also includes endogenous hormones. because the chemicals are not being inactivated, they build up in the axons | ||
| Line 50: | Line 50: | ||
2014-03-29 21:46:23 PJosepherum i have such a bad headache | 2014-03-29 21:46:23 PJosepherum i have such a bad headache | ||
2014-03-29 21:47:45 PJosepherum build up of epinephrine i think, or maybe the GABAergic system made me very twitchy. I was essentially in REM while awake lol | 2014-03-29 21:47:45 PJosepherum build up of epinephrine i think, or maybe the GABAergic system made me very twitchy. I was essentially in REM while awake lol | ||
2014-03-29 21:47:55 @ | 2014-03-29 21:47:55 @oskykins how much rue did you take? | ||
2014-03-29 21:47:57 PJosepherum very disphoric though because of the stress | 2014-03-29 21:47:57 PJosepherum very disphoric though because of the stress | ||
2014-03-29 21:48:41 PJosepherum erm, i pulverised ~3g with a hammer then brewed for 3 hours | 2014-03-29 21:48:41 PJosepherum erm, i pulverised ~3g with a hammer then brewed for 3 hours | ||
2014-03-29 21:49:00 PJosepherum in less than 20ml water | 2014-03-29 21:49:00 PJosepherum in less than 20ml water | ||
2014-03-29 21:50:21 @ | 2014-03-29 21:50:21 @oskykins aww ): when i took 5g grounded up, i had no negative body load | ||
2014-03-29 21:50:58 PJosepherum brewing the harmala in water allowed for dissolution of the alkaloids, which increased their bioavailability i think | 2014-03-29 21:50:58 PJosepherum brewing the harmala in water allowed for dissolution of the alkaloids, which increased their bioavailability i think | ||
2014-03-29 21:51:19 PJosepherum whole seeds were inactive, shorter duration of brewing gave spotty results | 2014-03-29 21:51:19 PJosepherum whole seeds were inactive, shorter duration of brewing gave spotty results | ||
2014-03-29 21:51:25 @ | 2014-03-29 21:51:25 @oskykins awesome. :D how are you brewing it? | ||
2014-03-29 21:52:05 @ | 2014-03-29 21:52:05 @oskykins do you get extreme stimulation initially from rue and then extreme sedation at the end? | ||
2014-03-29 21:52:17 PJosepherum stir harmala and enough boiling water to cover the solids in a mug, leave to extract | 2014-03-29 21:52:17 PJosepherum stir harmala and enough boiling water to cover the solids in a mug, leave to extract | ||
2014-03-29 21:52:26 PJosepherum both simultaniously | 2014-03-29 21:52:26 PJosepherum both simultaniously | ||
| Line 70: | Line 70: | ||
2014-03-29 21:57:05 PJosepherum if harmala supposedly stops being selective for MOA-A at 5g+ seeds, i wonder what preparation "5g of seeds" is lol | 2014-03-29 21:57:05 PJosepherum if harmala supposedly stops being selective for MOA-A at 5g+ seeds, i wonder what preparation "5g of seeds" is lol | ||
2014-03-29 21:57:35 PJosepherum long extracts of low quantities of harmala is probably safe and fun | 2014-03-29 21:57:35 PJosepherum long extracts of low quantities of harmala is probably safe and fun | ||
2014-03-29 21:57:36 @ | 2014-03-29 21:57:36 @oskykins wait can you explain the brewing process again? i put grounded rue in a mug, pour boiling water onto it from an electric kettle, stir it, and then what? | ||
2014-03-29 21:59:10 PJosepherum then wait for the alkaloids to dissolve into solution. there is a concentration gradient between the solids and the liquid; with time, the gradient homogenises so there will be the same concentration of alkaloids in the solid seeds as in the solvent | 2014-03-29 21:59:10 PJosepherum then wait for the alkaloids to dissolve into solution. there is a concentration gradient between the solids and the liquid; with time, the gradient homogenises so there will be the same concentration of alkaloids in the solid seeds as in the solvent | ||
2014-03-29 22:00:05 PJosepherum so 3 hours at room temperature is ample time; citric/acetic acid will speed up the dissolution | 2014-03-29 22:00:05 PJosepherum so 3 hours at room temperature is ample time; citric/acetic acid will speed up the dissolution | ||
2014-03-29 22:00:50 PJosepherum 30 minutes has been my fastest effective duration | 2014-03-29 22:00:50 PJosepherum 30 minutes has been my fastest effective duration | ||
2014-03-29 22:02:04 @ | 2014-03-29 22:02:04 @oskykins thanks pjose :DD i am going to try this in the next week or so | ||
2014-03-29 22:02:04 [22:02] | 2014-03-29 22:02:04 [22:02] | ||
2014-03-29 22:02:13 @ | 2014-03-29 22:02:13 @oskykins what did you mean by extract though? | ||
2014-03-29 22:03:04 PJosepherum it is the beta-carbolines which are responsible for the effects of harmala alkaloids. ergo, they can be separated from the seed matter by dissolution into a solvent | 2014-03-29 22:03:04 PJosepherum it is the beta-carbolines which are responsible for the effects of harmala alkaloids. ergo, they can be separated from the seed matter by dissolution into a solvent | ||
2014-03-29 22:03:17 PJosepherum soaking in water is essentially the extraction method | 2014-03-29 22:03:17 PJosepherum soaking in water is essentially the extraction method | ||
| Line 88: | Line 88: | ||
2014-03-29 22:07:24 PJosepherum 3g for 3 hours was too strong | 2014-03-29 22:07:24 PJosepherum 3g for 3 hours was too strong | ||
2014-03-29 22:08:00 PJosepherum lol i've been saying preganum for days, it's peganum xD | 2014-03-29 22:08:00 PJosepherum lol i've been saying preganum for days, it's peganum xD | ||
2014-03-29 22:09:21 @ | 2014-03-29 22:09:21 @oskykins lol hopefully i can save some money by brewing the rue | ||
2014-03-29 22:09:33 PJosepherum ok, so beta-carboline content is between 2-7% depending on quality. average is 3%. 3% of 3g is maybe 30mg harmala alkaloids | 2014-03-29 22:09:33 PJosepherum ok, so beta-carboline content is between 2-7% depending on quality. average is 3%. 3% of 3g is maybe 30mg harmala alkaloids | ||
2014-03-29 22:09:33 @ | 2014-03-29 22:09:33 @oskykins i'm going to try this this week | ||
2014-03-29 22:10:01 PJosepherum dude, low dose peganum can totally save money on drugs. if you're careful, coadministration can result in huge potentiation | 2014-03-29 22:10:01 PJosepherum dude, low dose peganum can totally save money on drugs. if you're careful, coadministration can result in huge potentiation | ||
2014-03-29 22:10:18 PJosepherum of i expect all psychoactives | 2014-03-29 22:10:18 PJosepherum of i expect all psychoactives | ||
2014-03-29 22:10:35 @ | 2014-03-29 22:10:35 @oskykins what drugs combine well with rue? i know 4-aco/shrooms and LSD do | ||
2014-03-29 22:11:28 PJosepherum anything euphoric or reinforcing will combine beautifully; opioids i bet will intensify an unreasonable amount | 2014-03-29 22:11:28 PJosepherum anything euphoric or reinforcing will combine beautifully; opioids i bet will intensify an unreasonable amount | ||
2014-03-29 22:11:47 PJosepherum ethanol was enhanced | 2014-03-29 22:11:47 PJosepherum ethanol was enhanced | ||
| Line 105: | Line 105: | ||
2014-03-29 22:15:11 PJosepherum i would like to find a safer way to sustain the activation of dmt | 2014-03-29 22:15:11 PJosepherum i would like to find a safer way to sustain the activation of dmt | ||
2014-03-29 22:15:54 PJosepherum i think harmala is responsible for the distortions i experience too. dmt isn't about visual glitches, it's about detail | 2014-03-29 22:15:54 PJosepherum i think harmala is responsible for the distortions i experience too. dmt isn't about visual glitches, it's about detail | ||
2014-03-29 22:16:14 @ | 2014-03-29 22:16:14 @oskykins ahh, i'm going to try combining it with LSD next | ||
2014-03-29 22:16:16 PJosepherum dmt enhances clarity, it doesn't distort senses | 2014-03-29 22:16:16 PJosepherum dmt enhances clarity, it doesn't distort senses | ||
2014-03-29 22:16:29 @ | 2014-03-29 22:16:29 @oskykins thanks for all the advice dude | ||
2014-03-29 22:16:37 @ | 2014-03-29 22:16:37 @oskykins i'm saving this convo | ||
2014-03-29 22:16:57 @ | 2014-03-29 22:16:57 @oskykins so i remember | ||
2014-03-29 22:16:59 PJosepherum be careful, start small. both of those drugs have long half lives. i expect LSD will be unbelievably potent with harmala lol. imagine salvia on it :| | 2014-03-29 22:16:59 PJosepherum be careful, start small. both of those drugs have long half lives. i expect LSD will be unbelievably potent with harmala lol. imagine salvia on it :| | ||
2014-03-29 22:17:51 @ | 2014-03-29 22:17:51 @oskykins yeah, josif told me it makes it more potent and changes the visuals to more mystical themes | ||
2014-03-29 22:17:51 [22:17] | 2014-03-29 22:17:51 [22:17] | ||
2014-03-29 22:21:01 <-- PJosepherum (PJosepherum@user/PJosepherum) has quit (Ping timeout: 121 seconds) | 2014-03-29 22:21:01 <-- PJosepherum (PJosepherum@user/PJosepherum) has quit (Ping timeout: 121 seconds) | ||
| Line 138: | Line 138: | ||
2014-03-29 22:33:02 [22:33] | 2014-03-29 22:33:02 [22:33] | ||
2014-03-29 22:33:15 PJosepherum well he didn't report safety, but didn't report unsafety lol | 2014-03-29 22:33:15 PJosepherum well he didn't report safety, but didn't report unsafety lol | ||
2014-03-29 22:33:31 @ | 2014-03-29 22:33:31 @oskykins wow you know a lot about this | ||
2014-03-29 22:33:48 @ | 2014-03-29 22:33:48 @oskykins you can help me breakdown syrian rue | ||
2014-03-29 22:33:51 @ | 2014-03-29 22:33:51 @oskykins for the wiki | ||
2014-03-29 22:34:42 PJosepherum definitely! it needs expanding. the current lore is way too dangerous, not enough emphasis on extraction and safety | 2014-03-29 22:34:42 PJosepherum definitely! it needs expanding. the current lore is way too dangerous, not enough emphasis on extraction and safety | ||
2014-03-29 22:35:11 PJosepherum understanding the mechanism allows for mitigation of negative consequences | 2014-03-29 22:35:11 PJosepherum understanding the mechanism allows for mitigation of negative consequences | ||
2014-03-29 22:35:22 @ | 2014-03-29 22:35:22 @oskykins yeah, you could write an extraction guide too | ||
2014-03-29 22:36:13 PJosepherum good idea | 2014-03-29 22:36:13 PJosepherum good idea | ||
2014-03-29 22:36:19 PJosepherum (with 500 mg, orally) "I took a half gram of pure synthetic harmaline after fasting for over a day. The resulting nausea was greatly attenuated after I vomited. At this dose there were intense and annoying visual disturbances, and complete collapse of motor co-ordination. I could barely stagger to the bathroom, and for safety's sake locomoted by crawling. Tracers and weird visual ripplings disturbed my sight with open eyes. With eyes clo | 2014-03-29 22:36:19 PJosepherum (with 500 mg, orally) "I took a half gram of pure synthetic harmaline after fasting for over a day. The resulting nausea was greatly attenuated after I vomited. At this dose there were intense and annoying visual disturbances, and complete collapse of motor co-ordination. I could barely stagger to the bathroom, and for safety's sake locomoted by crawling. Tracers and weird visual ripplings disturbed my sight with open eyes. With eyes clo | ||
| Line 157: | Line 157: | ||
2014-03-29 22:39:26 PJosepherum i don't feel safe pushing it, but i really want to know how microdoses of harmalas feel | 2014-03-29 22:39:26 PJosepherum i don't feel safe pushing it, but i really want to know how microdoses of harmalas feel | ||
2014-03-29 22:40:52 PJosepherum i also think abstinence from external chemical influence like food or drugs is necessary for an ensured pleasant experience | 2014-03-29 22:40:52 PJosepherum i also think abstinence from external chemical influence like food or drugs is necessary for an ensured pleasant experience | ||
2014-03-29 22:41:00 @ | 2014-03-29 22:41:00 @oskykins yeah, i know. xD this sounds unsafe | ||
2014-03-29 22:41:09 @ | 2014-03-29 22:41:09 @oskykins but i'll try it for science | ||
2014-03-29 22:41:32 PJosepherum very. lol. if too much messengers build up in the axons, they can damage receptors | 2014-03-29 22:41:32 PJosepherum very. lol. if too much messengers build up in the axons, they can damage receptors | ||
2014-03-29 22:42:25 PJosepherum receptors are hyperactivated, causing downstream distortions. the neuron mitigates the magnified signal by reducing the number of receptors presented on the membrane | 2014-03-29 22:42:25 PJosepherum receptors are hyperactivated, causing downstream distortions. the neuron mitigates the magnified signal by reducing the number of receptors presented on the membrane | ||
2014-03-29 22:42:29 PJosepherum within the axon | 2014-03-29 22:42:29 PJosepherum within the axon | ||
2014-03-29 22:43:27 @ | 2014-03-29 22:43:27 @oskykins lol shit | ||
2014-03-29 22:44:27 PJosepherum i can't discern which part of my eyes hurt and why. i think it's either a central headache from axon flooding or strained ocular muscles from the REM | 2014-03-29 22:44:27 PJosepherum i can't discern which part of my eyes hurt and why. i think it's either a central headache from axon flooding or strained ocular muscles from the REM | ||
2014-03-29 22:44:45 PJosepherum harmalas make me very twitchy | 2014-03-29 22:44:45 PJosepherum harmalas make me very twitchy | ||
| Line 168: | Line 168: | ||
2014-03-29 22:45:30 PJosepherum caused by either GABA or epinephrine | 2014-03-29 22:45:30 PJosepherum caused by either GABA or epinephrine | ||
2014-03-29 22:45:44 PJosepherum probably involves both | 2014-03-29 22:45:44 PJosepherum probably involves both | ||
2014-03-29 22:46:25 @ | 2014-03-29 22:46:25 @oskykins how much mimosa again? | ||
2014-03-29 22:46:38 PJosepherum 3g @ ~0.5% DMT | 2014-03-29 22:46:38 PJosepherum 3g @ ~0.5% DMT | ||
2014-03-29 22:46:51 PJosepherum so 15mg? | 2014-03-29 22:46:51 PJosepherum so 15mg? | ||
| Line 190: | Line 190: | ||
2014-03-29 23:01:38 PJosepherum lol | 2014-03-29 23:01:38 PJosepherum lol | ||
2014-03-29 23:01:45 PJosepherum again | 2014-03-29 23:01:45 PJosepherum again | ||
2014-03-29 23:02:09 @ | 2014-03-29 23:02:09 @oskykins lol that was you almost dying? | ||
2014-03-29 23:02:24 @ | 2014-03-29 23:02:24 @oskykins wait when did you die | ||
2014-03-29 23:02:32 PJosepherum i know to be extra extra careful now. it's really not a good idea for the internet lore to suggest such a basic preparation of peganum harmala | 2014-03-29 23:02:32 PJosepherum i know to be extra extra careful now. it's really not a good idea for the internet lore to suggest such a basic preparation of peganum harmala | ||
2014-03-29 23:02:52 PJosepherum almost die, i haven't actually died yet | 2014-03-29 23:02:52 PJosepherum almost die, i haven't actually died yet | ||