This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
MDMA/Synthesis: Difference between revisions
>Kenan m Use proper synth for MDMA by shulgin (previous was MDPEA by mistake) |
>David Hedlund References |
||
| (4 intermediate revisions by 2 users not shown) | |||
| Line 38: | Line 38: | ||
=== Synthesis === | === Synthesis === | ||
* From safrole (with aqueous HBr) to 5-(2-bromopropyl)benzo-1,3-dioxole; (with methyl amine in EtOH) to | * From safrole (with aqueous HBr) to 5-(2-bromopropyl)benzo-1,3-dioxole; (with methyl amine in EtOH) to MDMA (Merck, 1912; Bineicki and Krajewski, 1960). | ||
* From 3,4-methylenedioxyphenylacetone (aka: piperonylacetone; with methylamine, sodium cyanoborohydride) to | * From 3,4-methylenedioxyphenylacetone (aka: piperonylacetone; with methylamine, sodium cyanoborohydride) to MDMA (Braun et al., 1980). | ||
* From | * From MDA (with formic acid or ethyl formate) to ''N''-formyl-3,4-methylenedioxy amphetamine; (with LAH) to MDMA (Shulgin and Shulgin, 1991) | ||
* From isosafrole (with formic acid, H<sub>2</sub>0<sub>2</sub>) to 3,4-methylenedioxyphenylacetone; (with Al, HgCl<sub>2</sub>, CH<sub>3</sub>NH<sub>2</sub>) to | * From isosafrole (with formic acid, H<sub>2</sub>0<sub>2</sub>) to 3,4-methylenedioxyphenylacetone; (with Al, HgCl<sub>2</sub>, CH<sub>3</sub>NH<sub>2</sub>) to MDMA (Shulgin and Shulgin, 1991). | ||
* (For the optical isomers) from piperonylacetone (with ''R''-(-)- (or ''S''-(+)-) α-methylbenzyl amine, Raney Ni) to ''R'',''R''- (or ''S'',''S'') ''N''-α-methylbenzyl-MOA; (with Pd, H<sub>2</sub>) to ''R''-(-)- (or ''S''-(+)-) | * (For the optical isomers) from piperonylacetone (with ''R''-(-)- (or ''S''-(+)-) α-methylbenzyl amine, Raney Ni) to ''R'',''R''- (or ''S'',''S'') ''N''-α-methylbenzyl-MOA; (with Pd, H<sub>2</sub>) to ''R''-(-)- (or ''S''-(+)-) MDA; (with methyl formate) to ''R''-(+)- (or ''S''-(-) ''N''-formamido-MDA; (with LAH) to ''R''-(-) (or ''S''-(+)-) MDMA (Anderson et al., 1978a). | ||
== M. Swist, J. Wilamowski, A. Parczewski == | == M. Swist, J. Wilamowski, A. Parczewski == | ||
| Line 92: | Line 92: | ||
Two hundred milligrams of MDMA HCl was dissolved in 2 ml of buffer. Two different buffers, phosphate buffer, pH 7, and carbonate buffer, pH 10, were tested. The suspension was vigorously shaken (25 min) following by the addition of 200 ml of ''n''-heptane, containing diphenylamine as an internal standard, and then again shaken (25 min). The extracts were subjected to GC/MS analysis, and impurity profiles were obtained. | Two hundred milligrams of MDMA HCl was dissolved in 2 ml of buffer. Two different buffers, phosphate buffer, pH 7, and carbonate buffer, pH 10, were tested. The suspension was vigorously shaken (25 min) following by the addition of 200 ml of ''n''-heptane, containing diphenylamine as an internal standard, and then again shaken (25 min). The extracts were subjected to GC/MS analysis, and impurity profiles were obtained. | ||
=== External links === | |||
* [https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=109 MDMA (PiHKAL: A Chemical Love Story)] | |||
=== References === | |||
<references/> | <references/> | ||
[[category:Chemical synthesis]] | |||