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Proscaline: Difference between revisions

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'''4-Propyloxy-3,5-dimethoxyphenethylamine''' (also known as '''proscaline''') is a lesser-known [[Psychoactive class::psychedelic]] substance of the [[Chemical class::phenethylamine]] class.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal140.shtml|chapter=#140. P}}</ref> It is a structurally related to [[mescaline]] and belongs to a series of mescaline analogs that include [[isoproscaline]], [[escaline]] and [[allylescaline]].  
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| ''[[Proscaline/Summary|Summary sheet: Proscaline]]''
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'''Proscaline''' (also known as '''4-propyloxy-3,5-dimethoxyphenethylamine''') is a [[Psychoactive class::psychedelic]] of the [[Chemical class::phenethylamine]] class.<ref>Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml</ref> It has structural and pharmacological properties similar to its parent drug [[mescaline]] as well as to its analogs such as [[isoproscaline]], [[escaline]] and [[allylescaline]].  


Proscaline was first synthesized by [[Alexander Shulgin]] and later documented in his book "[[PiHKAL]]: A Chemical Love Story". In modern times it is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area [[research chemical]] through the use of online vendors. It is relatively obscure and has only a short history of human use.
The synthesis of proscaline was first published by David E. Nichols in 1977.<ref>{{cite journal|title=Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogs|last1=Nichols|first1=D. E.|author-link1=David E. Nichols|last2=Dyer|first2=D. C.|year=1977|volume=20|issue=2|pages=299-301|doi=10.1021/jm00212a022|pmid=836502|journal=Journal of Medicinal Chemistry|issn=0022-2623|eissn=1520-4804|oclc=39480771}}</ref> Around the same time, [[Alexander Shulgin]] sampled and evaluated the chemical at doses up to 60 mg, estimating its potency as five times that of [[mescaline]].<ref>{{cite book|author=Alexander Shulgin|author-link=Alexander Shulgin|title=Pharmacology Notes II (The Shulgin Lab Books)|publisher=Erowid|url=https://erowid.org/library/books_online/shulgin_labbooks/shulgin_pharmacology_notebook9_searchable.pdf|page=209|place=Lafayette, CA|year=1980}}</ref>  Shulgin later documented his findings in the 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). Proscaline appeared for sale on the online research chemical market in the 2010s.{{citation needed}}
 
[[Subjective effects]] are similar to [[mescaline]] and include [[geometry|open and closed-eye visuals]], [[time distortion]], [[introspection|enhanced introspection]], [[conceptual thinking]], [[euphoria]], and [[ego loss]]. However, it is reported to produce significantly less visual effects, euphoria, and ego loss than mescaline. As a result of its limited recreational potential, demand for the substance is relatively limited. It may have potential utility as an adjunct in psychedelic therapy, although this has yet to be explored.
 
Very little data exists about the pharmacological properties, metabolism, and toxicity of proscaline. It is assumed to have a risk profile [[Mescaline#Toxicity and harm potential|similar to mescaline]], although this has not been confirmed in studies. It is highly advised to use [[harm reduction practices]] if using this substance.


==Chemistry==
==Chemistry==
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{{effectStub}}
{{effectStub}}
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
===Physical effects===
{{effects/base
|{{effects/physical|
*'''[[Effect::Spontaneous tactile sensations]]'''
*'''[[Effect::Spontaneous tactile sensations]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased heart rate]]'''
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*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''


===Cognitive effects===
}}
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Delusions]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Unity and interconnectedness]]'''


===Visual effects===
{{effects/visual|
====Enhancements====
====Enhancements====
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
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*'''[[Effect::Diffraction]]'''
*'''[[Effect::Diffraction]]'''


===[[Effect::Geometry]]===
====[[Effect::Geometry]]====


====Hallucinatory states====
====Hallucinatory states====
*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')


===Auditory effects===
}}
 
|{{effects/cognitive|
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Delusion]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Unity and interconnectedness]]'''
 
}}
 
{{effects/auditory|
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
}}
}}
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
*[https://erowid.org/experiences/subs/exp_Proscaline.shtml Erowid Experience Vaults: Proscaline]


==Toxicity and harm potential==
==Toxicity and harm potential==
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It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
===Tolerance and addiction potential===
===Tolerance and addiction potential===
Proscaline is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  
Proscaline is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with use. It is most often self-regulating.  


Tolerance to the effects of proscaline are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). proscaline presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of proscaline all psychedelics will have a reduced effect.
Tolerance to the effects of proscaline is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). proscaline presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of proscaline all psychedelics will have a reduced effect.


==Legal issues==
==Legal status==
{{legalStub}}
{{legalStub}}
*'''United States:''' Proscaline is uncontrolled in the United States, but could be considered an analog of mescaline under the Federal Analog Act.
 
*'''United Kingdom:''' Proscaline is a Class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.
*'''Germany''': Proscaline is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of November 26, 2016.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|pages=2615-2622|issn=0341-1095|oclc=1004462279|publisher=Bundesanzeiger Verlag|date=November 21, 2016|publication-date=November 25, 2016|language=de|work=Bundesgesetzblatt Jahrgang 2016 Teil I Nr. 55}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of proscaline are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
*'''Switzerland''': Proscaline can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': Proscaline is a Class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.{{citation needed}}
*'''United States''': Proscaline is uncontrolled in the United States.


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Psychoactive substance index]]
*[[Psychoactive substance index]]
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==External links==
==External links==
*[http://en.wikipedia.org/wiki/Proscaline Proscaline (Wikipedia)]
*[http://en.wikipedia.org/wiki/Proscaline Proscaline (Wikipedia)]
*[https://www.erowid.org/library/books_online/pihkal/pihkal140.shtml Proscaline (PiHKAL)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=140 Proscaline (PiHKAL / Isomer Design)]
*[http://www.bluelight.org/vb/threads/392410-The-Big-amp-Dandy-Proscaline-Thread Proscaline (Bluelight)]
*[http://www.bluelight.org/vb/threads/392410-The-Big-amp-Dandy-Proscaline-Thread Proscaline (Bluelight)]
*[http://drugs.tripsit.me/proscaline proscaline (Tripsit)]


==References==
==References==
<references/>
<references />
{{#set:Featured=true}}
{{#set:Featured=true}}
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Psychedelic]]
[[Category:Phenethylamine]]
[[Category:Phenethylamine]]
[[Category:Psychedelic]]
[[Category:Research chemical]]
Retrieved from "http://psy.st/wiki/Proscaline"