4-HO-MPT: Difference between revisions

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{{SummarySheet}}
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{{SubstanceBox/4-HO-MPT}}
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| ''[[4-HO-MPT/Summary|Summary sheet: 4-HO-MPT]]''
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'''4-Hydroxy-N-methyl-N-propyltryptamine''' (also known as '''4-HO-MPT''') is a novel and obscure [[hallucinogen]]ic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class and can be considered to be [[structural analog]] of [[4-HO-DMT]] (i.e. ''Psilocin'') and other hallucinogenic tryptamines with powerful psychedelic effects.


Little is currently known about this substance, though it is starting to gain interest amongst psychonauts who seek out these types of experiences.<ref>http://www.bluelight.org/vb/members/377522-Kaleida|View Profile: Kaleida | Bluelight</ref>
'''4-Hydroxy-N-methyl-N-propyltryptamine''' (also known as '''4-HO-MPT''' or '''Meprocin''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is a closely related structural analog of [[4-HO-DMT]] (''Psilocin'') and other hallucinogenic tryptamines with powerful psychedelic effects.


Today it is either used rarely as a [[recreational drug use|recreational drug]] or as [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors on which it first appeared as recently as mid 2016.  
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. It has been sold online as a [[research chemical]] as of 2016.{{citation needed}} It was synthesised and described by Alexander Shulgin in his 1994 book TiHKAL.<ref name="TiHKAL">{{cite book|title=TiHKAL: The Continuation|title-link=TiHKAL|last1=Shulgin|first1=Alexander|last2=Shulgin|first2=Ann|author-link1=Alexander Shulgin|year=1997|publisher=Transform Press|location=United States|isbn=0-9630096-9-9|oclc=38503252|chapter-url=https://erowid.org/library/books_online/tihkal/tihkal23.shtml|chapter=#23. 4-HO-MPT}}</ref>


==Chemistry==
==Chemistry==
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==Pharmacology==
==Pharmacology==
{{Main|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
Like with most [[psychedelic]] tryptamines, 4-HO-EPT is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-HO-EPT's binding efficacy at the 5-HT<sub>2A</sub> receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
4-HO-MPT is a psychedelic drug in the [[Tryptamines|tryptamine]] class of chemical compounds and is a higher homologue of the naturally occurring substituted tryptamine [[psilocin]] as well as being the 4-hydroxyl analog of [[MPT]].<ref>https://www.erowid.org/library/books_online/tihkal/tihkal23.shtml</ref>
 
Like with most [[psychedelic]] tryptamines, 4-HO-MPT is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-HO-MPT's binding efficacy at the 5-HT<sub>2A</sub> receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.


==Subjective effects==
==Subjective effects==
{{effectStub}}
{{effectStub}}
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
===Physical effects===
{{effects/base
*'''[[Effect::Spontaneous tactile sensations]]'''
 
|{{effects/physical|
*'''[[Effect::Spontaneous physical sensations]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Nausea]]'''
*'''[[Effect::Nausea]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''


===Cognitive effects===
}}
*'''[[Effect::Conceptual thinking]]'''
{{effects/visual|
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Delusions]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Unity and interconnectedness]]'''
 
===Visual effects===
====Enhancements====
====Enhancements====
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
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*'''[[Effect::Diffraction]]'''
*'''[[Effect::Diffraction]]'''


===[[Effect::Geometry]]===
====[[Effect::Geometry]]====


====Hallucinatory states====
====Hallucinatory states====
*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
 
}}
|{{effects/cognitive|
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Delusion]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''


===Auditory effects===
}}
{{effects/auditory|
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
}}
{{effects/transpersonal|
*'''[[Effect::Unity and interconnectedness]]'''
}}
}}
===Experience reports===
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{#ask: [[Category:4-HO-MPT]][[Category:Experience]]|format=ul|Columns=2}}
Additional experience reports can be found here:
*[https://erowid.org/experiences/subs/exp_4HOMPT.shtml Erowid Experience Vaults: 4-HO-MPT]


==Toxicity and harm potential==
==Toxicity and harm potential==
{|  
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
|-
The toxicity and long-term health effects of recreational 4-HO-MPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-MPT is a [[research chemical]] with very little history of human usage.  
| [[File:Lolol.png|17px]]''Main articles: [[Research chemicals#Toxicity and harm potential|Research chemicals § Toxicity and harm potential]]'' ''&'' ''[[Responsible use #Hallucinogens|Responsible use § Hallucinogens]]''
|}
The toxicity and long-term health effects of recreational 4-HO-MPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-MPT is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-MPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.  


It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
Anecdotal evidence from people within the community who have tried it suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
 
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.


===Tolerance and addiction potential===
===Tolerance and addiction potential===
4-HO-MPT is generally considered [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.  
4-HO-MPT is generally considered [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.  


Tolerance to the effects of 4-HO-MPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MPT all psychedelics will have a reduced effect.
Tolerance to the effects of 4-HO-MPT is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MPT all psychedelics will have a reduced effect.


==Legal issues==
===Dangerous interactions===
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}
 
==Legal status==
Due to its relative obscurity, the possession and sale of 4-HO-MPT is unscheduled in most countries.  
Due to its relative obscurity, the possession and sale of 4-HO-MPT is unscheduled in most countries.  


*'''United Kingdom:'''It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
*'''Germany''': 4-HO-MPT is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MPT are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
*'''United States:'''4-HO-MPT is unscheduled in the United States. It may be considered an analog of [[psilocin]] (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analog Act.
*'''Switzerland''': 4-HO-MPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': 4-HO-MPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
*'''United States''': 4-HO-MPT is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Research chemical]]
*[[Research chemical]]
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==External links==
==External links==
*[https://en.wikipedia.org/wiki/4-HO-MPT 4-HO-MPT (Wikipedia)]
*[https://erowid.org/chemicals/4_ho_mpt/4_ho_mpt.shtml 4-HO-MPT (Erowid Vault)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=23 4-HO-MPT (TiHKAL / Isomer Design)]
*[http://www.bluelight.org/vb/threads/550416-The-Big-amp-Dandy-4-HO-MPT-Thread The Big & Dandy 4-HO-MPT Thread (Bluelight)]
*[http://www.bluelight.org/vb/threads/550416-The-Big-amp-Dandy-4-HO-MPT-Thread The Big & Dandy 4-HO-MPT Thread (Bluelight)]


==References==
==References==
<references/>
<references />
 
[[Category:Substance]]
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Research chemical]]
[[Category:Hallucinogen]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Tryptamine]]
[[Category:Tryptamine]]
[[Category:Research chemical]]


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{{#set:Featured=true}}