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A '''psychoactive substance''' is a chemical compound which crosses the blood–brain barrier and acts primarily upon the central nervous system where it affects brain function, resulting in alterations in sensation, perception, mood, consciousness, cognition, and behaviour. Psychoactive substances are used for a number of purposes; for example, they can be taken recreationally to purposefully alter one's consciousness, as [[entheogens]] for ritual, spiritual, or shamanic purposes or as tools for studying or augmenting the mind. Many psychoactive drugs have therapeutic utility, (e.g., anesthetics, analgesics or for the treatment of psychiatric disorders).
A '''psychoactive substance''' is a chemical substance—other than a nutrient or essential dietary ingredient—that alters brain function to produce temporary changes in sensation, perception, mood, consciousness, cognition, and behavior.  


This index attempts to categorize and provide relevant, accurate and unbiased information regarding any and all psychoactive substances with particular focus on those which are useful as tools for exploring one's own conscious mind. The individual articles focus not just on detailing the chemistry, pharmacology, toxicity and harm potential of each substance but also their subjective effects in a comprehensive level of detail. This is done by following a standardized system of organization with descriptions and terminologies that can be found within the [[subjective effects index]].
Psychoactive substances have been used by humans for a variety of purposes since recorded history. For example, they may be used as medicine, as recreational substances for their euphoric effects and novelty value, as [[entheogens]] for ritual or spiritual purposes, or as scientific research probes for studying the brain and mind. The latter two have particular relevance for practitioners of [[psychonautics]].


'''Please see our [[summary index]] to view convenient and condensed versions of these articles.'''
The '''''Psychoactive Substance Index''''' ('''PSI''') is designed to catalog and provide relevant, accurate, and unbiased information for any and all mind-altering substances known to humankind, with a special focus on those with potential applications as mind-expanding tools.
 
The individual articles detail not just the history, chemistry, pharmacology, toxicity, and legality of each substance, but also its user-reported subjective effects (i.e. phenomenology). This is achieved in accordance with a standardized system of definitions and terminologies proposed in the [[subjective effect index|'''''Subjective Effect Index''''']] ('''SEI''').
 
'''Please see our [[summary index]] to view conveniently condensed versions of each article.'''
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'''Note:''' This list should only include substances that have a ''documented history of human use''. Do not include substances that are merely theoretical or lack reliable user experience reports and data!