Tetrahydrocannabiphorol: Difference between revisions

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'''3. Modern Cultural Emergence (Post-2019)'''

THCP entered popular cannabis culture after 2020 via online cannabis forums, Reddit threads, and YouTube reviews, especially among enthusiasts fascinated by novel cannabinoids.

THCP entered popular cannabis culture after 2020 via online cannabis forums, Reddit threads, and YouTube reviews, especially among enthusiasts fascinated by novel cannabinoids. It’s been referred to as the “next THC”, “super-THC,” or “the strongest natural cannabinoid”, often in sensationalized language.

~~It’s been referred to as the “next THC”, “super-THC,” or “the strongest natural cannabinoid”, often in sensationalized language.~~

''Marketing claims'':

Many vape and extract brands began advertising “THCP carts” or “ultra-potent gummies” despite no clear regulatory framework or dose guidelines. Concerns were raised in scientific and regulatory communities regarding:

''Marketing claims'': Many vape and extract brands began advertising “THCP carts” or “ultra-potent gummies” despite no clear regulatory framework or dose guidelines.

Concerns were raised in scientific and regulatory communities regarding:

- Overstated potency claims (e.g., “33x stronger than THC”) being misinterpreted as "33x more intoxicating".

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- Potential for unexpected psychotropic effects, especially when combined with THC.

📝 Reference:

Reference:

Radwan MM et al., Cannabis and Cannabinoid Research, 2021 (DOI:10.1089/can.2020.0101)

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It's full chemical name is (–)-trans‑Δ⁹‑tetrahydrocannabiphorol, also known as THC‑Heptyl

'''

'''1. Receptor binding & in vitro potency'''

1. Receptor binding & in vitro potency'''

In radioligand binding assays with human CB₁ receptors, Δ⁹‑THCP showed a Kᵢ ≈ 1.2 nM, nearly matching CP55940 (a full CB₁ agonist, Kᵢ ≈ 0.9 nM)

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In the FM2 cannabis strain, Δ⁹‑THCP was found in trace quantities (~29 µg/g of decarboxylated extract—0.0029%)

A 2021 survey reported it in Δ⁹‑THC–dominant strains at 0.0023%–0.0136% by weight, undetectable in CBD-dominant chemotypes

@@ Line 25: / Line 25: @@
 '''3. Modern Cultural Emergence (Post-2019)'''
-THCP entered popular cannabis culture after 2020 via online cannabis forums, Reddit threads, and YouTube reviews, especially among enthusiasts fascinated by novel cannabinoids.
+THCP entered popular cannabis culture after 2020 via online cannabis forums, Reddit threads, and YouTube reviews, especially among enthusiasts fascinated by novel cannabinoids. It’s been referred to as the “next THC”, “super-THC,” or “the strongest natural cannabinoid”, often in sensationalized language.
-It’s been referred to as the “next THC”, “super-THC,” or “the strongest natural cannabinoid”, often in sensationalized language.
+''Marketing claims'':
+Many vape and extract brands began advertising “THCP carts” or “ultra-potent gummies” despite no clear regulatory framework or dose guidelines. Concerns were raised in scientific and regulatory communities regarding:
-''Marketing claims'': Many vape and extract brands began advertising “THCP carts” or “ultra-potent gummies” despite no clear regulatory framework or dose guidelines.
-Concerns were raised in scientific and regulatory communities regarding:
 - Overstated potency claims (e.g., “33x stronger than THC”) being misinterpreted as "33x more intoxicating".
@@ Line 39: / Line 36: @@
 - Potential for unexpected psychotropic effects, especially when combined with THC.
-📝 Reference:
+Reference:
 Radwan MM et al., Cannabis and Cannabinoid Research, 2021 (DOI:10.1089/can.2020.0101)
@@ Line 51: / Line 48: @@
 It's full chemical name is (–)-trans‑Δ⁹‑tetrahydrocannabiphorol, also known as THC‑Heptyl
-'''
+'''1. Receptor binding & in vitro potency'''
-. Receptor binding & in vitro potency'''
 In radioligand binding assays with human CB₁ receptors, Δ⁹‑THCP showed a Kᵢ ≈ 1.2 nM, nearly matching CP55940 (a full CB₁ agonist, Kᵢ ≈ 0.9 nM)
@@ Line 75: / Line 71: @@
 In the FM2 cannabis strain, Δ⁹‑THCP was found in trace quantities (~29 µg/g of decarboxylated extract—0.0029%)
 A 2021 survey reported it in Δ⁹‑THC–dominant strains at 0.0023%–0.0136% by weight, undetectable in CBD-dominant chemotypes