Talk:Tilidine: Difference between revisions

← Older edit

@@ Line 1: / Line 1: @@
+{{headerpanel|{{Approval}}}}
 {{headerpanel|{{DepressantOD|opiates}}}}
+{{SubstanceBox/Tilidine}}
+{{SummarySheet}}
-'''Tilidine''' (also known as '''Ethyl-6-(dimethylamino)-3,6-dihydro-[1,1`-biphenyl]-1(2H)-carboxylat''') is a synthetic [[psychoactive class::opioid]]
+'''Tilidine''' (known under brand names including '''Valoron''', '''Valtran''', '''Tilicomp''') is a synthetic [[opioid]] analgesic. Tilidine is mainly used in some European countries such as Germany, Belgium, Luxembourg, Switzerland and also South Africa. As is the case with other opioids, it is also commonly used as a recreational drug.{{citation needed}}
-Tilidine is an opioid pain medication used to relieve moderate to severe pain. It's often combined with naloxone to reduce the risk of misuse. As with any opioid, it should only be used under the supervision of a healthcare professional and as prescribed, as it can be habit-forming and has potential side effects.
+==Pharmacology==
+Tilidine itself is only a weak µ-opioid agonist. Its pharmacological activity when administered is mediated by its active major metabolite nortilidine, which is further metabolised to the also active bisnortilidine. Tilidine is therefore a prodrug. The demethylation of tilidine to nortilidine and bisnortilidine occures in the liver and is catalysed  by the Cytochrome P450 family of enzymes, mainly by CYP3A4 CYP2D6 and CYP2C19. <ref>J. Weiss, E. Sawa, K.-D. Riedel, W. E. Haefeli, G. Mikus: In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6. In: Naunyn-Schmiedeberg’s Arch. Pharmacol. 378, 2008, S. 275–282, doi:10.1007/s00210-008-0294-7.</ref>
-'''Dosage:'''
+==Subjective effects==
+{{EffectStub}}
+{{Preamble/SubjectiveEffects}}
+{{effects/base
-Treshhold: 20-50mg
+|{{effects/physical|
+*'''[[Effect::Sedation]]'''
+*'''[[Pain relief]]'''
+*'''[[Itchiness]]'''
+*'''[[Constipation]]'''
+*'''[[Cough suppression]]'''
+*'''[[Decreased libido]]'''
+*'''[[Difficulty urinating]]'''
+*'''[[Nausea]]'''
+*'''[[Stomach cramps]]'''
+*'''[[Pupil constriction]]'''
+*'''[[Orgasm suppression]]'''
+}}
-Light: 50-80mg
+|{{effects/cognitive|
+*'''[[Cognitive euphoria]]'''
+*'''[[Anxiety suppression]]'''
+*'''[[Compulsive redosing]]'''
+*'''[[Dream potentiation]]'''
+*'''[[Increased music appreciation]]'''
+}}
+}}
-Common: 80-150mg
+==Toxicity and harm potential==
+{{toxicity}}
-Strong: 150-200mg
+===Lethal dosage===
+Death with as little as 750 mg has been reported, in combination with barbiturates.
-Heavy: 200-400mg
+===Dangerous interactions===
+{{DangerousInteractions}}
+{{DangerousInteractions/Intro}}
+{{DangerousInteractions/Opioids}}
+==See also==
+*[[Responsible use]]
+==External links==
+*[https://en.wikipedia.org/wiki/Tilidine Tilidine (Wikipedia)]
+*[https://isomerdesign.com/pihkal/explore/10836 Tilidine (Isomer Design)]
+*[https://go.drugbank.com/drugs/DB13787 Tilidine (DrugBank)]
+*[https://www.apotheken-umschau.de/medikamente/beipackzettel/tilidin-comp-stada-50-mg4-mg-retardtabletten-2003310.html Tilidin (Offical German pharmacy Journal)]
+==References==
 <references />
+[[Category:Psychoactive substance]]
+[[Category:Proofread]]
+[[Category:Approval]]