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Unique substance warnings: Difference between revisions
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===[[Dosage]]=== | ===[[Dosage]]=== | ||
====Steep dose response curve==== | |||
* [[2C-B]]: "There is a steep dose response curve. Over the 12 to 24 milligram range, every 2 milligrams can make a profound increase or change of response. Initially, one should go lightly, and increase the dosage in subsequent trials by small increments."<ref>http://www.erowid.org/library/books_online/pihkal/pihkal020.shtml</ref> | * [[2C-B]]: "There is a steep dose response curve. Over the 12 to 24 milligram range, every 2 milligrams can make a profound increase or change of response. Initially, one should go lightly, and increase the dosage in subsequent trials by small increments."<ref>http://www.erowid.org/library/books_online/pihkal/pihkal020.shtml</ref> | ||
* [[2C-P]]: 2C-P is known to have a steep dose-response curve, as little as a few extra milligrams separating a manageable dose and an overdose. Also, 2C-P can have a very slow onset if ingested, and peak effects reportedly do not occur for 3 to 5 hours. "There was one report of an experience in which a single dosage of 16 mg was clearly an overdose, with the entire experiment labeled a physical disaster, not to be repeated. A consistent observation is that there may not be too much latitude in dosage between that which would be modest, or adequate, and that which would be excessive. The need for individual titration would be most important with this compound."<ref>http://isomerdesign.com/PiHKAL/read.php?id=36&domain=pk</ref> | * [[2C-P]]: 2C-P is known to have a steep dose-response curve, as little as a few extra milligrams separating a manageable dose and an overdose. Also, 2C-P can have a very slow onset if ingested, and peak effects reportedly do not occur for 3 to 5 hours. "There was one report of an experience in which a single dosage of 16 mg was clearly an overdose, with the entire experiment labeled a physical disaster, not to be repeated. A consistent observation is that there may not be too much latitude in dosage between that which would be modest, or adequate, and that which would be excessive. The need for individual titration would be most important with this compound."<ref>http://isomerdesign.com/PiHKAL/read.php?id=36&domain=pk</ref> | ||
====Slow onset==== | |||
* [[2C-P]]: Onset 1-3 hours. - https://www.erowid.org/library/books_online/pihkal/pihkal036.shtml | |||
====Long half-life==== | |||
The anecdotal estimated elimination half-life is 19 hours.<ref>https://pubmed.ncbi.nlm.nih.gov/28130544/</ref> | |||
===[[Routes of administration]]=== | ===[[Routes of administration]]=== | ||
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===Genotype=== | ===Genotype=== | ||
* [[MDMA]]: There is a small percentage of people, who due to their race and family history, have a lower level of the liver enzyme P450 2D6. This can cause them to be more sensitive to MDMA, requiring lower doses and extra caution should be taken.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref> | * [[MDMA]]: There is a small percentage of people, who due to their race and family history, have a lower level of the liver enzyme P450 2D6. This can cause them to be more sensitive to MDMA, requiring lower doses and extra caution should be taken.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref> | ||
* [[Nitrous oxide]]: ''Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant.''<ref>https://pubmed.ncbi.nlm.nih.gov/23856660/</ref> | |||
* [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref> | * [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref> | ||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||