DOM: Difference between revisions

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'''2,5-Dimethoxy-4-methylamphetamine''' (also known as '''DOM''' and '''STP''' or '''"Serenity, Tranquility and Peace"''') is a lesser-known [[psychoactive class::psychedelic]] substance of the [[chemical class::Substituted amphetamine|amphetamine]] class. DOM is a member of the [[DOx]] family of compounds which are known for their high potency, long duration, and mixture of [[psychedelic]] and [[stimulant]] effects. It produces its effects by acting on [[serotonin]] receptors in the brain.

DOM was first synthesized and tested in 1963 by [[Alexander Shulgin]].<ref name="DOM">~~Shulgin, Alexander (1991).~~ PiHKAL: A Chemical Love Story~~. Berkeley, CA:~~ Transform Press~~. pp. 53–56.~~</ref> It attained some popularity during the summer of 1967 under the name "STP" ("Serenity, Tranquility, and Peace"),<ref>~~"STP's~~ faster, ~~here's~~ why~~". Berkeley Barb, June~~ 16~~-22,~~ 1967~~. 3-5 (Independent Voices)~~ | http://voices.revealdigital.com/cgi-bin/independentvoices?a=d&d=BFBJFGD19670616.1.3</ref> but its use was short-lived due to its side effects. In 1991, the synthesis and pharmacology of DOM was published in Shulgin's book ''[[PiHKAL]]'' ("Phenethylamines I Have Known And Loved").<ref name="PiHKAL">{{Citation | title=Erowid Online Books : “PIHKAL” - The Chemical Story | url=https://www.erowid.org/library/books_online/pihkal/pihkal.shtml}}</ref>.

DOM was first synthesized and tested in 1963 by [[Alexander Shulgin]].<ref name="DOM">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|pages=53-56}}</ref> It attained some popularity during the summer of 1967 under the name "STP" ("Serenity, Tranquility, and Peace"),<ref>{{cite journal | vauthors=((Berkeley, B.)) | journal=Independent Voices | title=STP’s faster, here’s why | pages=3–5 | date=16 April 1967 | url=http://voices.revealdigital.com/cgi-bin/independentvoices?a=d&d=BFBJFGD19670616.1.3}}</ref> but its use was short-lived due to its side effects. In 1991, the synthesis and pharmacology of DOM was published in Shulgin's book ''[[PiHKAL]]'' ("Phenethylamines I Have Known And Loved").<ref name="PiHKAL">{{Citation | title=Erowid Online Books : “PIHKAL” - The Chemical Story | url=https://www.erowid.org/library/books_online/pihkal/pihkal.shtml}}</ref>.

Over the years, DOM has gained a reputation for being a highly dose-sensitive psychedelic that is often sold on blotting paper and known for its strong visuals, body load and neutral, analytical headspace. Many reports also indicate that the effects of this chemical may be overly difficult to use for those who are not already experienced with psychedelics.

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*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>{{cite journal | vauthors=((Talaie, H.)), ((Panahandeh, R.)), ((Fayaznouri, M. R.)), ((Asadi, Z.)), ((Abdollahi, M.)) | journal=Journal of Medical Toxicology | title=Dose-independent occurrence of seizure with tramadol | volume=5 | issue=2 | pages=63–67 | date= June 2009 | url=http://link.springer.com/10.1007/BF03161089 | issn=1556-9039 | doi=10.1007/BF03161089}}</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}

*'''[[DangerousInteraction::Lithium]]''':<ref>{{Citation | vauthors=((Nayak, S.)), ((Gukasyan, N.)), ((Barrett, F. S.)), ((Erowid, E.)), ((Erowid, F.)), ((Griffiths, R. R.)) | year=2021 | title=Classic psychedelic coadministration with lithium, but not lamotrigine, is associated with seizures: an analysis of online psychedelic experience reports | publisher=PsyArXiv | url=https://osf.io/r726d}}</ref> Lithium is commonly prescribed in the treatment of bipolar disorder; however, there is a large body of anecdotal evidence that suggests taking it with psychedelics can significantly increase the risk of [[psychosis]] and [[seizures]].<ref>{{cite web|url=https://erowid.org/experiences/exp.php?ID=83935|title=A Nice Little Trip to the Hospital: Lithium & LSD|author=<nowiki>"wanderlei"</nowiki>|publisher=Erowid|publication-date=October 3, 2010|access-date=January 7, 2020|id=ExpID: 83935|work=Erowid Experience Vaults}}</ref><ref>{{cite web|url=https://erowid.org/experiences/exp.php?ID=75153|title=Having a Seizure and Passing Out: Lithium & LSD|author=<nowiki>"MissDja1a"</nowiki>|publisher=Erowid|publication-date=December 16, 2008|access-date=January 7, 2020|id=ExpID: 75153|work=Erowid Experience Vaults}}</ref><ref>{{cite web|url=https://www.reddit.com/r/Psychonaut/comments/17uspp/please_read_a_cautionary_tale_concerning_lsd|title=Please Read: a cautionary tale concerning LSD|author=<nowiki>"throwaway_naut"</nowiki>|publisher=Reddit|work=r/Psychonaut|year=2014|access-date=January 7, 2020}}</ref> As a result, this combination should be '''strictly avoided'''.

*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis~~.{{citation needed}}~~

*'''[[[[UnsafeInteraction::Tramadol|Tramadol]]]]''' - Tramadol lowers the seizure threshold<ref>{{cite journal | vauthors=((Talaie, H.)), ((Panahandeh, R.)), ((Fayaznouri, M. R.)), ((Asadi, Z.)), ((Abdollahi, M.)) | journal=Journal of Medical Toxicology | title=Dose-independent occurrence of seizure with tramadol | volume=5 | issue=2 | pages=63–67 | date= June 2009 | url=http://link.springer.com/10.1007/BF03161089 | issn=1556-9039 | doi=10.1007/BF03161089}}</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}

*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}

*'''[[[[UncertainInteraction::Stimulants|Stimulants]]]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}

==Legal status==

@@ Line 4: / Line 4: @@
 '''2,5-Dimethoxy-4-methylamphetamine''' (also known as '''DOM''' and '''STP''' or '''"Serenity, Tranquility and Peace"''') is a lesser-known [[psychoactive class::psychedelic]] substance of the [[chemical class::Substituted amphetamine|amphetamine]] class. DOM is a member of the [[DOx]] family of compounds which are known for their high potency, long duration, and mixture of [[psychedelic]] and [[stimulant]] effects. It produces its effects by acting on [[serotonin]] receptors in the brain.
-DOM was first synthesized and tested in 1963 by [[Alexander Shulgin]].<ref name="DOM">Shulgin, Alexander (1991). PiHKAL: A Chemical Love Story. Berkeley, CA: Transform Press. pp. 53–56.</ref> It attained some popularity during the summer of 1967 under the name "STP" ("Serenity, Tranquility, and Peace"),<ref>"STP's faster, here's why". Berkeley Barb, June 16-22, 1967. 3-5 (Independent Voices) | http://voices.revealdigital.com/cgi-bin/independentvoices?a=d&d=BFBJFGD19670616.1.3</ref> but its use was short-lived due to its side effects. In 1991, the synthesis and pharmacology of DOM was published in Shulgin's book ''[[PiHKAL]]'' ("Phenethylamines I Have Known And Loved").<ref name="PiHKAL">{{Citation | title=Erowid Online Books : “PIHKAL” - The Chemical Story | url=https://www.erowid.org/library/books_online/pihkal/pihkal.shtml}}</ref>.
+DOM was first synthesized and tested in 1963 by [[Alexander Shulgin]].<ref name="DOM">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|pages=53-56}}</ref> It attained some popularity during the summer of 1967 under the name "STP" ("Serenity, Tranquility, and Peace"),<ref>{{cite journal | vauthors=((Berkeley, B.)) | journal=Independent Voices | title=STP’s faster, here’s why | pages=3–5 | date=16 April 1967 | url=http://voices.revealdigital.com/cgi-bin/independentvoices?a=d&d=BFBJFGD19670616.1.3}}</ref> but its use was short-lived due to its side effects. In 1991, the synthesis and pharmacology of DOM was published in Shulgin's book ''[[PiHKAL]]'' ("Phenethylamines I Have Known And Loved").<ref name="PiHKAL">{{Citation | title=Erowid Online Books : “PIHKAL” - The Chemical Story | url=https://www.erowid.org/library/books_online/pihkal/pihkal.shtml}}</ref>.
 Over the years, DOM has gained a reputation for being a highly dose-sensitive psychedelic that is often sold on blotting paper and known for its strong visuals, body load and neutral, analytical headspace. Many reports also indicate that the effects of this chemical may be overly difficult to use for those who are not already experienced with psychedelics.
@@ Line 150: / Line 150: @@
 {{DangerousInteractions/Intro}}
-*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>{{cite journal | vauthors=((Talaie, H.)), ((Panahandeh, R.)), ((Fayaznouri, M. R.)), ((Asadi, Z.)), ((Abdollahi, M.)) | journal=Journal of Medical Toxicology | title=Dose-independent occurrence of seizure with tramadol | volume=5 | issue=2 | pages=63–67 | date= June 2009 | url=http://link.springer.com/10.1007/BF03161089 | issn=1556-9039 | doi=10.1007/BF03161089}}</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
+*'''[[DangerousInteraction::Lithium]]''':<ref>{{Citation | vauthors=((Nayak, S.)), ((Gukasyan, N.)), ((Barrett, F. S.)), ((Erowid, E.)), ((Erowid, F.)), ((Griffiths, R. R.)) | year=2021 | title=Classic psychedelic coadministration with lithium, but not lamotrigine, is associated with seizures: an analysis of online psychedelic experience reports | publisher=PsyArXiv | url=https://osf.io/r726d}}</ref> Lithium is commonly prescribed in the treatment of bipolar disorder; however, there is a large body of anecdotal evidence that suggests taking it with psychedelics can significantly increase the risk of [[psychosis]] and [[seizures]].<ref>{{cite web|url=https://erowid.org/experiences/exp.php?ID=83935|title=A Nice Little Trip to the Hospital: Lithium & LSD|author=<nowiki>&quot;wanderlei&quot;</nowiki>|publisher=Erowid|publication-date=October 3, 2010|access-date=January 7, 2020|id=ExpID: 83935|work=Erowid Experience Vaults}}</ref><ref>{{cite web|url=https://erowid.org/experiences/exp.php?ID=75153|title=Having a Seizure and Passing Out: Lithium & LSD|author=<nowiki>&quot;MissDja1a&quot;</nowiki>|publisher=Erowid|publication-date=December 16, 2008|access-date=January 7, 2020|id=ExpID: 75153|work=Erowid Experience Vaults}}</ref><ref>{{cite web|url=https://www.reddit.com/r/Psychonaut/comments/17uspp/please_read_a_cautionary_tale_concerning_lsd|title=Please Read: a cautionary tale concerning LSD|author=<nowiki>&quot;throwaway_naut&quot;</nowiki>|publisher=Reddit|work=r/Psychonaut|year=2014|access-date=January 7, 2020}}</ref> As a result, this combination should be '''strictly avoided'''.
-*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
+*'''[[[[UnsafeInteraction::Tramadol|Tramadol]]]]''' - Tramadol lowers the seizure threshold<ref>{{cite journal | vauthors=((Talaie, H.)), ((Panahandeh, R.)), ((Fayaznouri, M. R.)), ((Asadi, Z.)), ((Abdollahi, M.)) | journal=Journal of Medical Toxicology | title=Dose-independent occurrence of seizure with tramadol | volume=5 | issue=2 | pages=63–67 | date= June 2009 | url=http://link.springer.com/10.1007/BF03161089 | issn=1556-9039 | doi=10.1007/BF03161089}}</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
-*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
+*'''[[[[UncertainInteraction::Stimulants|Stimulants]]]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
 ==Legal status==