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{{SubstanceBox/2C-B}} | {{SubstanceBox/2C-B}} | ||
'''4-Bromo-2,5-dimethoxyphenethylamine''' (also known as '''Nexus''', '''Bromo Mescaline''', '''BDMPEA''', '''Venus''', and '''2C-B''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class. | '''4-Bromo-2,5-dimethoxyphenethylamine''' (also known as '''Nexus''', '''Bromo Mescaline''', '''BDMPEA''', '''Venus''', and '''2C-B''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class. | ||
It is perhaps the most well-known member of the [[2C-x family]], which are structurally related to the classical psychedelic [[mescaline]]. | It is perhaps the most well-known member of the [[2C-x family]], which are structurally related to the classical psychedelic [[mescaline]]. The mechanism of action is not fully known, although [[serotonin]] [[receptor]] binding activity is thought to be principally involved. | ||
2C-B was discovered in 1974 by the American chemist [[Alexander Shulgin]], who was investigating psychedelic phenethylamines derived from mescaline.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal020.shtml|chapter=#20. 2C-B}}</ref><ref>{{cite journal|last1=Shulgin|first1=A. T.|author-link1=Alexander Shulgin|last2=Carter|first2=M. F.|title=Centrally active phenethylamines|journal=Psychopharmacology Communications|year=1975|volume=1|issue=1|pages=93–98|pmid=1223994|issn=0098-616X|oclc=924603662}}</ref> | 2C-B was discovered in 1974 by the American chemist [[Alexander Shulgin]], who was investigating psychedelic phenethylamines derived from [[mescaline]].<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal020.shtml|chapter=#20. 2C-B}}</ref><ref>{{cite journal|last1=Shulgin|first1=A. T.|author-link1=Alexander Shulgin|last2=Carter|first2=M. F.|title=Centrally active phenethylamines|journal=Psychopharmacology Communications|year=1975|volume=1|issue=1|pages=93–98|pmid=1223994|issn=0098-616X|oclc=924603662}}</ref> | ||
In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref> | In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref> | ||
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Smaller doses (under 15 mg) are reported to be useful as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect. | Smaller doses (under 15 mg) are reported to be useful as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect. | ||
While more research is needed, it is generally thought to be physiologically well-tolerated | While more research is needed, it is generally thought to be physiologically well-tolerated{{Citation needed}}. It likely has a [[Psychedelics#Toxicity and harm potential|safety profile similar to classical psychedelics]], which are known to have low abuse potential and toxicity. However, adverse psychological reactions such as severe [[anxiety]], [[paranoia]], [[delusions]], [[psychosis]] are always possible, particularly for those predisposed to mental disorders.<ref>{{cite journal|last=Strassmann|first=Rick|title=Adverse reactions to psychedelic drugs. A review of the literature|journal=Journal of Nervous and Mental Disease|volume=172|issue=10|pages=577–595|doi=10.1097/00005053-198410000-00001|pmid=6384428|year=1984|issn=0022-3018|oclc=1754691}}</ref> | ||
It is highly advised to use [[harm reduction practices]] if using this substance. | It is highly advised to use [[harm reduction practices]] if using this substance. | ||
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Shortly after gaining traction in the underground psychotherapy community, 2C-B became popular in the recreational drug scene. It was well-liked as a [[MDMA]] substitute in raves and club parties due to its minimal comedown and a clear, euphoric headspace. | Shortly after gaining traction in the underground psychotherapy community, 2C-B became popular in the recreational drug scene. It was well-liked as a [[MDMA]] substitute in raves and club parties due to its minimal comedown and a clear, euphoric headspace. | ||
In the 1980s and early 1990s, several foreign companies legally manufactured the substance under the brand names "Nexus", "Erox", and "Performax" and advertised that it would alleviate impotence, frigidity, and diminished libido. It was sold at adult book and video stores, "head" shops, and some nightclubs. The DEA reported its distribution in Miami, Florida in the form of yellow pills marketed as an aphrodisiac. | In the 1980s and early 1990s, several foreign companies legally manufactured the substance under the brand names "Nexus", "Erox", and "Performax" and advertised that it would alleviate impotence, frigidity, and diminished libido. It was sold at adult book and video stores, "head" shops, and some nightclubs. The DEA reported its distribution in Miami, Florida in the form of yellow pills marketed as an aphrodisiac.<ref>https://www.justice.gov/archive/ndic/pubs0/665/665p.pdf</ref> | ||
In the United States, it gained popularity as an alternative to MDMA after the latter was classified as a Schedule I substance in 1985. The increasing popularity of 2C-B led to it also being placed in Schedule I in 1995.<ref name="DEA2001" /> It saw a resurgence in interest in the 2000s, with the advent of the [[research chemicals|"research chemicals"]]/"designer drugs" scene and darknet markets. | In the United States, it gained popularity as an alternative to MDMA after the latter was classified as a Schedule I substance in 1985. The increasing popularity of 2C-B led to it also being placed in Schedule I in 1995.<ref name="DEA2001" /> It saw a resurgence in interest in the 2000s, with the advent of the [[research chemicals|"research chemicals"]]/"designer drugs" scene and darknet markets. | ||
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==Subjective effects== | ==Subjective effects== | ||
{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
{{effects/base | {{effects/base | ||
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*'''[[Effect::Stimulation]]''' - 2C-B is typically described as very energetic and stimulating in a fashion that draws comparisons to [[MDMA]]. At higher doses this effect can become more forced, encouraging users to engage in physical activities such as dancing. | *'''[[Effect::Stimulation]]''' - 2C-B is typically described as very energetic and stimulating in a fashion that draws comparisons to [[MDMA]]. At higher doses this effect can become more forced, encouraging users to engage in physical activities such as dancing. | ||
*'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of 2C-B is reported to be one of the most complex among [[psychedelics]], exhibiting aspects of [[MDMA]], [[2C-E]], and [[LSD]]. This is first characterized by an intense soft, warm glow that grows over the body and is capable of becoming highly [[Effect::physical euphoria|euphoric]]. | *'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of 2C-B is reported to be one of the most complex among [[psychedelics]], exhibiting aspects of [[MDMA]], [[2C-E]], and [[LSD]]. This is first characterized by an intense soft, warm glow that grows over the body and is capable of becoming highly [[Effect::physical euphoria|euphoric]]. | ||
*'''[[Effect::Nausea]]''' - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the user has vomited or gradually fades by itself as the peak sets in. | *'''[[Effect::Nausea]]''' - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the user has vomited or gradually fades by itself as the peak sets in. | ||
*'''[[Effect::Appetite suppression]]''' - While not as intense as stimulants such as [[MDMA]], most doses can cause a decrease in appetite. | |||
*'''[[Effect::Bodily control enhancement]]''' | *'''[[Effect::Bodily control enhancement]]''' | ||
*'''[[Effect::Increased blood pressure]]''' | *'''[[Effect::Increased blood pressure]]'''<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859368/</ref> | ||
*'''[[Effect::Increased bodily temperature]]'''{{citation needed}} | *'''[[Effect::Increased bodily temperature]]'''{{citation needed}} | ||
*'''[[Effect::Increased heart rate]]''' | *'''[[Effect::Increased heart rate]]'''<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859368/</ref> | ||
*'''[[Effect::Increased perspiration]]''' | *'''[[Effect::Increased perspiration]]''' | ||
*'''[[Effect::Dehydration]]'''{{citation needed}} | *'''[[Effect::Dehydration]]'''{{citation needed}} | ||
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*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as [[MDMA]] but still prove stronger and more consistent than other [[psychedelic]]s of any class. This has been reported to provide long-lasting therapeutic effects. | *'''[[Effect::Empathy, affection, and sociability enhancement]]''' - These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as [[MDMA]] but still prove stronger and more consistent than other [[psychedelic]]s of any class. This has been reported to provide long-lasting therapeutic effects. | ||
*'''[[Effect::Analysis enhancement]]''' - This [[introspection]] dominant effect is only manifested consistently in the context of a non-social setting in which the user is alone. | *'''[[Effect::Analysis enhancement]]''' - This [[introspection]] dominant effect is only manifested consistently in the context of a non-social setting in which the user is alone. | ||
*'''[[Effect::Anxiety]] & [[Paranoia]]''' - while possible at most doses, this effect generally occurs at a considerably lower intensity compared to classical psychedelics such as [[LSD]] and [[psilocybin mushrooms]]. | |||
*'''[[Effect::Conceptual thinking]]''' | *'''[[Effect::Conceptual thinking]]''' | ||
*'''[[Effect::Delusion]]''' | *'''[[Effect::Delusion]]''' | ||
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*'''[[Effect::Immersion enhancement]]''' | *'''[[Effect::Immersion enhancement]]''' | ||
*'''[[Effect::Novelty enhancement]]''' | *'''[[Effect::Novelty enhancement]]''' | ||
*'''[[Effect::Increased libido]]''' | *'''[[Effect::Increased libido]]''' - Combined with the increased bodily sensations and stimulation, 2C-B is capable of making sexual activity extremely pleasurable. | ||
*'''[[Effect::Increased music appreciation]]''' - | |||
*'''[[Effect::Increased sense of humor]]''' | *'''[[Effect::Increased sense of humor]]''' | ||
*'''[[Laughter fits]]''' - Anecdotal reports and literature suggest that 2C-B is capable of producing sudden fits of mild to intense laughter. | *'''[[Laughter fits]]''' - Anecdotal reports and literature suggest that 2C-B is capable of producing sudden fits of mild to intense laughter. | ||
*'''[[Effect::Memory suppression]]''' | *'''[[Effect::Memory suppression]]''' | ||
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*'''Argentina''': 2C-B is a Schedule I controlled substance.<ref>{{cite web|url=http://www.cicad.oas.org/fortalecimiento_institucional/legislations/PDF/AR/decreto_299.pdf|title=Decreto 299/2010: Actualización de la lista de estupefacientes y demás sustancias químicas que deberán ser incluidas en losalcances de la Ley Nº 23.737.|access-date=December 10, 2019|language=Spanish|date=February 3, 2010}}</ref> | *'''Argentina''': 2C-B is a Schedule I controlled substance.<ref>{{cite web|url=http://www.cicad.oas.org/fortalecimiento_institucional/legislations/PDF/AR/decreto_299.pdf|title=Decreto 299/2010: Actualización de la lista de estupefacientes y demás sustancias químicas que deberán ser incluidas en losalcances de la Ley Nº 23.737.|access-date=December 10, 2019|language=Spanish|date=February 3, 2010}}</ref> | ||
*'''Australia''': 2C-B is | *'''Australia''': 2C-B is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard.<ref name="Poisons Standard">{{cite web |url= https://www.comlaw.gov.au/Details/F2015L01534 |title=Poisons Standard October 2015 |work=Federal Register of Legislation }}</ref> A Schedule 9 substance is a substance which may be abused or misused and the manufacture, possession, sale or use of is prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.<ref name="Poisons Standard" /> | ||
*'''Austria''': 2C-B is illegal to possess, produce and sell in Austria under the SMG (Suchtmittelgesetz Österreich). 2C-B is listed in Schedule V of the Suchtgiftverordnung, which further specifies the SMG.<ref>{{cite web|url=https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=10011053|title=Bundesrecht konsolidiert: Gesamte Rechtsvorschrift für Suchtgiftverordnung|access-date=January 10, 2021|language=German|date=May 18, 2020}}</ref> | *'''Austria''': 2C-B is illegal to possess, produce and sell in Austria under the SMG (Suchtmittelgesetz Österreich). 2C-B is listed in Schedule V of the Suchtgiftverordnung, which further specifies the SMG.<ref>{{cite web|url=https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=10011053|title=Bundesrecht konsolidiert: Gesamte Rechtsvorschrift für Suchtgiftverordnung|access-date=January 10, 2021|language=German|date=May 18, 2020}}</ref> | ||
*'''Belgium''': 2C-B is illegal to possess, produce and sell in Belgium.{{citation needed}} | *'''Belgium''': 2C-B is illegal to possess, produce and sell in Belgium.{{citation needed}} | ||
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*[https://erowid.org/chemicals/2cb/2cb.shtml 2C-B (Erowid Vault)] | *[https://erowid.org/chemicals/2cb/2cb.shtml 2C-B (Erowid Vault)] | ||
*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=20 2C-B (PiHKAL / Isomer Design)] | *[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=20 2C-B (PiHKAL / Isomer Design)] | ||
*[https://go.drugbank.com/drugs/DB01537 2C-B (DrugBank)] | |||
===Discussion=== | ===Discussion=== | ||
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|R6=OCH₃ | |R6=OCH₃ | ||
}} | }} | ||
[[Category:Aphrodisiac]] | |||