DPT: Difference between revisions

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DPT was first synthesized in 1950.<ref>{{cite journal|last1=Li|first1=J. X.|last2=Rice|first2=K.|last3=France|first3=C. P.|year=2007|title=Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity|journal=Behavioural Pharmacology|issn=0955-8810|eissn=1473-5849|oclc=22170289|volume=18|issue=4|pages=283-288|doi=10.1097/FBP.0b013e3281f19ca0|pmid=17551320}}</ref> Human use was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>{{cite journal|last1=Grof|first1=S.|last2=Soskin|first2=R. A.|last3=Richards|first3=W. A.|last4=Kurland|first4=A. A.|title=DPT as an Adjunct in Psychotherapy of Alcoholics|year=1973|journal=International Pharmacopsychiatry|issn=0020-8272|oclc=1753673|doi=10.1159/000467979|pmid=4150711|volume=8|issue=1|pages=104-115}}</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>{{cite journal|last1=Richards|first1=W. A.|last2=Rhead|first2=J. C.|last3=Dileo|first3=F. B.|last4=Yensen|first4=R.|last5=Kurland|first5=A. A.|title=The Peak Experience Variable in DPT-Assisted Psychotherapy with Cancer Patients|year=1977|volume=9|issue=1|journal=Journal of Psychedelic Drugs|pages=1-10|issn=0022-393X|oclc=7565359|doi=10.1080/02791072.1977.10472020}}</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>{{cite web|title=Temple of the True Inner Light|access-date=January 9, 2020|url=http://psychede.tripod.com/}}</ref>

DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light". More ~~experiences~~ members ingest a DPT tea. {{citation needed}}

DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light". More experienced members ingest a DPT tea. {{citation needed}}

Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. It is highly advised to approach this powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] when using it.

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Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor antagonist also imply a 5-HT1A-mediated component to the actions of DPT.<ref>~~antegrossi WE~~, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter ~~JC (January 2008~~)~~. "~~Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): ~~possible~~ mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents~~". ''Pharmacology, Biochemistry, and Behavior''. '''~~88~~''' (~~3): ~~358–65~~. doi:10.1016/j.pbb.2007.09.007~~. PMC 2322878. <nowiki>PMID 17905422</nowiki>.~~</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor antagonist also imply a 5-HT1A-mediated component to the actions of DPT.<ref>{{cite journal | vauthors=((Fantegrossi, W.)), ((Reissig, C.)), ((Katz, E.)), ((Yarosh, H.)), ((Rice, K.)), ((Winter, J.)) | journal=Pharmacology Biochemistry and Behavior | title=Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents | volume=88 | issue=3 | pages=358–365 | date= January 2008 | url=https://linkinghub.elsevier.com/retrieve/pii/S0091305707002894 | issn=00913057 | doi=10.1016/j.pbb.2007.09.007}}</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

==Subjective effects==

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{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/</ref>

The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>{{Citation | vauthors=((Tribune, B. D. S.)) | title=Carver County teen’s death puts spotlight on ease of purchasing synthetic drugs online | url=https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/}}</ref>

Anecdotal reports from those who have taken DPT suggests that negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it ~~very~~ sparingly (although nothing can be guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

Anecdotal reports from those who have taken DPT suggests that negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it sparingly (although nothing can be guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

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*'''United States''': DPT is unscheduled in most of the United States. However, some states prohibited DPT, making it illegal to buy, sell, or possess:

**'''Florida''': DPT is a Schedule I controlled substance.<ref>{{cite web|url=http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html|title=Title XLVI: Chapter 893: Drug Abuse Prevention And Control|work=The 2019 Florida Statutes|access-date=January 10, 2020|publisher=The Florida Legislature}}</ref>

**'''Maine''': DPT is a Schedule I controlled substance.~~{{citation needed|date=October 2020}}~~

**'''Maine''': DPT is a Schedule X controlled substance.<ref>http://legislature.maine.gov/statutes/17-a/title17-Asec1102.html</ref>

**'''Oklahoma''': DPT is a Schedule I controlled substance.<ref>{{cite web|archive-url=https://web.archive.org/web/20190709113340/http://www.oscn.net/applications/oscn/DeliverDocument.asp?CiteID=98866|archive-date=July 9, 2019|url=http://www.oscn.net/applications/oscn/DeliverDocument.asp?CiteID=98866|title=Section 2-204 - Schedule I|work=Oklahoma Statutes Citationized|date=January 11, 2019|access-date=January 10, 2020|publisher=Oklahoma Judicial Center}}</ref>

@@ Line 5: / Line 5: @@
 DPT was first synthesized in 1950.<ref>{{cite journal|last1=Li|first1=J. X.|last2=Rice|first2=K.|last3=France|first3=C. P.|year=2007|title=Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity|journal=Behavioural Pharmacology|issn=0955-8810|eissn=1473-5849|oclc=22170289|volume=18|issue=4|pages=283-288|doi=10.1097/FBP.0b013e3281f19ca0|pmid=17551320}}</ref> Human use was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>{{cite journal|last1=Grof|first1=S.|last2=Soskin|first2=R. A.|last3=Richards|first3=W. A.|last4=Kurland|first4=A. A.|title=DPT as an Adjunct in Psychotherapy of Alcoholics|year=1973|journal=International Pharmacopsychiatry|issn=0020-8272|oclc=1753673|doi=10.1159/000467979|pmid=4150711|volume=8|issue=1|pages=104-115}}</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>{{cite journal|last1=Richards|first1=W. A.|last2=Rhead|first2=J. C.|last3=Dileo|first3=F. B.|last4=Yensen|first4=R.|last5=Kurland|first5=A. A.|title=The Peak Experience Variable in DPT-Assisted Psychotherapy with Cancer Patients|year=1977|volume=9|issue=1|journal=Journal of Psychedelic Drugs|pages=1-10|issn=0022-393X|oclc=7565359|doi=10.1080/02791072.1977.10472020}}</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>{{cite web|title=Temple of the True Inner Light|access-date=January 9, 2020|url=http://psychede.tripod.com/}}</ref>
-DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light". More experiences members ingest a DPT tea. {{citation needed}}
+DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light". More experienced members ingest a DPT tea. {{citation needed}}
 Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. It is highly advised to approach this powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] when using it.
@@ Line 17: / Line 17: @@
 {{pharmacology}}
 {{Further|Serotonergic psychedelic}}
-Studies on rodents have found that the effectiveness with which a selective 5-HT<sub>2A</sub> receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT<sub>2A</sub> receptor is an important site of action for DPT, but the modulatory actions of a 5-HT<sub>1A</sub> receptor antagonist also imply a 5-HT<sub>1A</sub>-mediated component to the actions of DPT.<ref>antegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter JC (January 2008). "Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents". ''Pharmacology, Biochemistry, and Behavior''. '''88''' (3): 358–65. doi:10.1016/j.pbb.2007.09.007. PMC 2322878. <nowiki>PMID 17905422</nowiki>.</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
+Studies on rodents have found that the effectiveness with which a selective 5-HT<sub>2A</sub> receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT<sub>2A</sub> receptor is an important site of action for DPT, but the modulatory actions of a 5-HT<sub>1A</sub> receptor antagonist also imply a 5-HT<sub>1A</sub>-mediated component to the actions of DPT.<ref>{{cite journal | vauthors=((Fantegrossi, W.)), ((Reissig, C.)), ((Katz, E.)), ((Yarosh, H.)), ((Rice, K.)), ((Winter, J.)) | journal=Pharmacology Biochemistry and Behavior | title=Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents | volume=88 | issue=3 | pages=358–365 | date= January 2008 | url=https://linkinghub.elsevier.com/retrieve/pii/S0091305707002894 | issn=00913057 | doi=10.1016/j.pbb.2007.09.007}}</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
 ==Subjective effects==
@@ Line 133: / Line 133: @@
 {{toxicity}}
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
-The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/</ref>
+The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>{{Citation | vauthors=((Tribune, B. D. S.)) | title=Carver County teen’s death puts spotlight on ease of purchasing synthetic drugs online | url=https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/}}</ref>
-Anecdotal reports from those who have taken DPT suggests that negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it very sparingly (although nothing can be guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+Anecdotal reports from those who have taken DPT suggests that negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it sparingly (although nothing can be guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
@@ Line 161: / Line 161: @@
 *'''United States''': DPT is unscheduled in most of the United States. However, some states prohibited DPT, making it illegal to buy, sell, or possess:
 **'''Florida''': DPT is a Schedule I controlled substance.<ref>{{cite web|url=http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html|title=Title XLVI: Chapter 893: Drug Abuse Prevention And Control|work=The 2019 Florida Statutes|access-date=January 10, 2020|publisher=The Florida Legislature}}</ref>
-**'''Maine''': DPT is a Schedule I controlled substance.{{citation needed|date=October 2020}}
+**'''Maine''': DPT is a Schedule X controlled substance.<ref>http://legislature.maine.gov/statutes/17-a/title17-Asec1102.html</ref>
 **'''Oklahoma''': DPT is a Schedule I controlled substance.<ref>{{cite web|archive-url=https://web.archive.org/web/20190709113340/http://www.oscn.net/applications/oscn/DeliverDocument.asp?CiteID=98866|archive-date=July 9, 2019|url=http://www.oscn.net/applications/oscn/DeliverDocument.asp?CiteID=98866|title=Section 2-204 - Schedule I|work=Oklahoma Statutes Citationized|date=January 11, 2019|access-date=January 10, 2020|publisher=Oklahoma Judicial Center}}</ref>