Releasing agent: Difference between revisions

Releasing agents act to varying extents on the monoamine neurotransmitters. Some will induce the release of all three monoamines; an example of this is [[MDMA]]. Others are more selective as [[methamphetamine]] is a potent releasing agent of dopamine and noradrenaline, but is a weak releaser of serotonin. A majority of releasing agents are non-selective, but there are currently a limited amount of agents that release serotonin (SRAs) or norephinephrine (NRAs) selectively; no selective dopamine releasing agents are currently known. Many tryptamines, such as [[DMT]], [[DiPT]], and [[psilocin]], are selective serotonin releasing agents in addition to their other pharmacological effects.<ref>Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB (October 2014). "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology 231 (21): 4135–44. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/24800892</ref>