2C-T-7: Difference between revisions

'''2,5-Dimethoxy-4-propylthiophenethylamine''' (also known as '''2C-T-7''', '''Blue Mystic''',<ref name="microgram">Zimmerman, M.M., “The identification of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7).” Microgram, Vol. XXXIV, No. 7, July 2001, pp. 169-173.</ref> and '''Beautiful''',<ref name="microgram" /> among others) is a [[Psychoactive class::psychedelic]] substance of the [[Chemical class::phenethylamine]] chemical class that produces [[psychedelic]] and [[entactogenic]] effects when [[routes of administration|administered]].  

2C-T-7 was first synthesized by [[Alexander Shulgin]] and documented in his book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref>https://erowid.org/library/books_online/pihkal/pihkal.shtml | [[PiHKAL]] </ref> It is a  member of the [[2C-x]] family of psychedelic phenethylamines, all of which were derived from the systematic modification of the [[mescaline]] molecule.  

This particular compound is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which -- with the exception of [[mescaline]] -- he designed, synthesized and tested on himself. They can be found within the first book of PiHKAL, and are as follows: [[Mescaline]], [[DOM]], [[2C-B]], [[2C-E]], [[2C-T-2]] and [[2C-T-7]].<ref>https://erowid.org/library/books_online/pihkal/pihkal.shtml | [[PiHKAL]] </ref>

2C-T-7 is analogous to 2C-T-2; the two differ by the length of the alkane chain in their thioether functional group.<ref>http://isomerdesign.com/PiHKAL/read.php?id=43</ref>

2C-T-7's [[psychedelic]] effects have been shown to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT_2A receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats | http://link.springer.com/article/10.1007%2Fs00213-005-0009-4</ref> However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

With serious adverse effects seen on overdoses of this compound (potentially [[Serotonin Syndrome]]) and as the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase A inhibitor<ref name="WagmannBrandt2019">{{cite journal|last1=Wagmann|first1=Lea|last2=Brandt|first2=Simon D.|last3=Stratford|first3=Alexander|last4=Maurer|first4=Hans H.|last5=Meyer|first5=Markus R.|title=Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases|journal=Drug Testing and Analysis|volume=11|issue=2|year=2019|pages=318–324|issn=19427603|doi=10.1002/dta.2494}}</ref> and many of the amphetamine-analogs of the [[2C-T-x]] series are highly selective MAO-A inhibitors (with [[ALEPH-7]] being one of the most potent), this substance is widely thought to also have [[MAOI]] effects.

As of August 2007, there have been at least three reported deaths associated with the use of 2C-T-7. These incidents occurred with insufflated doses of 30 mg or more<ref>Curtis, B., Kemp, P., Harty, L., Choi, C., & Christensen, D. (2003). Postmortem identification and quantitation of 2, 5-dimethoxy-4-n-propylthiophenethylamine using GC-MSD and GC-NPD. Journal of analytical toxicology, 27(7), 493-498.</ref>, or in combination with stimulants such as MDMA,{{citation needed}}. There have also been a number of reports describing concerning physical side effects and hospitalizations, typically following insufflation.<ref name="T74">2C-T-7 Overdoses & Delirium | https://www.erowid.org/chemicals/2ct7/2ct7_effects.shtml#overdose</ref>

Tolerance to the effects of 2C-T-7 are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-T-7 presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-T-7 all psychedelics will have a reduced effect.

If 2C-T-7 does have [[MAOI]] effects as commonly speculated, this could indicate that 2C-T-7 is more likely to induce [[serotonin syndrome]] or general [[neurotransmitter]] overload (especially at high dosages) than other [[serotonergic psychedelic]]s.<ref>Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109</ref> This may make it dangerous to combine it with other [[MAOI]]s, [[stimulant]]s and certain substances which releases neurotransmitters such as [[serotonin]] or [[dopamine]]. These substances include but are not limited to:

*'''Australia''' - In Australia, 2C-T-2 and 2C-T-7 are covered by the country's analog drug laws.{{citation needed}}

*'''Austria:''' 2C-T-7 is illegal to possess, produce and sell under the SMG. (Suchtmittelgesetz Österreich)

*'''Brazil''' - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.<ref>http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7</ref>

*'''Canada:''' 2C-T-7 is considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28</ref>

*'''China''' - As of October 2015 2C-T-7 is a controlled substance in China.<ref>{{cite web | url=http://www.sfda.gov.cn/WS01/CL0056/130753.html | title=关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | publisher=China Food and Drug Administration | date=27 September 2015 | language=Chinese | accessdate=1 October 2015}}</ref>

*'''Germany''' - Possession, production and sale is illegal.<ref>BtMG Anlage I | https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html </ref>

*'''Latvia''' - 2C-T-7 is a Schedule I controlled substance in Latvia.<ref>Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086</ref>

*'''Netherlands''' - The Netherlands was the first country in the world to ban 2C-T-7 after being sold in smart shops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market but was soon banned as well. 2C-T-7 is a list I drug of the Opium Law.{{citation needed}}

*'''Sweden''' - The drug is Schedule I in Sweden.<ref>http://www.lakemedelsverket.se/upload/lvfs/LVFS_2004-3.pdf</ref> 2C-T-7 was first classified as a health hazard under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated as "the Act on the Prohibition of Certain Goods Dangerous to Health") that made it illegal to sell or possess as of April 1, 1999.{{citation needed}}

*'''Switzerland:''' Possession, production and sale is illegal.<ref>http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html</ref>

*'''United Kingdom''' - 2C-T-7 is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made</ref>

*'''United States''' - On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA. On March 18, 2004, the DEA published a final rule in the Federal Register which permanently placed 2C-T-7 in Schedule I.{{citation needed}}