User:Oskykins/More writings and notes (talk): Difference between revisions

2014-03-29 21:43:53 lolwut|PJosepherum but i realised today that inhibiting MAOs is a really dirty hack

2014-03-29 21:44:04 -- lolwut|PJosepherum is now known as PJosepherum

2014-03-29 21:45:52 PJosepherum MAO-A and -B break down monamines; this includes alkaloids like dmt, nicotine, ethanol, opioids, etc, but also includes endogenous hormones. because the chemicals are not being inactivated, they build up in the axons

2014-03-29 21:46:23 PJosepherum i have such a bad headache

2014-03-29 21:47:45 PJosepherum build up of epinephrine i think, or maybe the GABAergic system made me very twitchy. I was essentially in REM while awake lol

2014-03-29 21:47:57 PJosepherum very disphoric though because of the stress

2014-03-29 21:48:41 PJosepherum erm, i pulverised ~3g with a hammer then brewed for 3 hours

2014-03-29 21:49:00 PJosepherum in less than 20ml water

2014-03-29 21:50:58 PJosepherum brewing the harmala in water allowed for dissolution of the alkaloids, which increased their bioavailability i think

2014-03-29 21:51:19 PJosepherum whole seeds were inactive, shorter duration of brewing gave spotty results

2014-03-29 21:52:17 PJosepherum stir harmala and enough boiling water to cover the solids in a mug, leave to extract

2014-03-29 21:52:26 PJosepherum both simultaniously

2014-03-29 21:57:05 PJosepherum if harmala supposedly stops being selective for MOA-A at 5g+ seeds, i wonder what preparation "5g of seeds" is lol

2014-03-29 21:57:35 PJosepherum long extracts of low quantities of harmala is probably safe and fun

2014-03-29 21:59:10 PJosepherum then wait for the alkaloids to dissolve into solution. there is a concentration gradient between the solids and the liquid; with time, the gradient homogenises so there will be the same concentration of alkaloids in the solid seeds as in the solvent

2014-03-29 22:00:05 PJosepherum so 3 hours at room temperature is ample time; citric/acetic acid will speed up the dissolution

2014-03-29 22:00:50 PJosepherum 30 minutes has been my fastest effective duration

2014-03-29 22:02:04 [22:02]

2014-03-29 22:03:04 PJosepherum it is the beta-carbolines which are responsible for the effects of harmala alkaloids. ergo, they can be separated from the seed matter by dissolution into a solvent

2014-03-29 22:03:17 PJosepherum soaking in water is essentially the extraction method

2014-03-29 22:07:24 PJosepherum 3g for 3 hours was too strong

2014-03-29 22:08:00 PJosepherum lol i've been saying preganum for days, it's peganum xD

2014-03-29 22:09:33 PJosepherum ok, so beta-carboline content is between 2-7% depending on quality. average is 3%. 3% of 3g is maybe 30mg harmala alkaloids

2014-03-29 22:10:01 PJosepherum dude, low dose peganum can totally save money on drugs. if you're careful, coadministration can result in huge potentiation

2014-03-29 22:10:18 PJosepherum of i expect all psychoactives

2014-03-29 22:11:28 PJosepherum anything euphoric or reinforcing will combine beautifully; opioids i bet will intensify an unreasonable amount

2014-03-29 22:11:47 PJosepherum ethanol was enhanced

2014-03-29 22:15:11 PJosepherum i would like to find a safer way to sustain the activation of dmt

2014-03-29 22:15:54 PJosepherum i think harmala is responsible for the distortions i experience too. dmt isn't about visual glitches, it's about detail

2014-03-29 22:16:16 PJosepherum dmt enhances clarity, it doesn't distort senses

2014-03-29 22:16:59 PJosepherum be careful, start small. both of those drugs have long half lives. i expect LSD will be unbelievably potent with harmala lol. imagine salvia on it :|

2014-03-29 22:17:51 [22:17]

2014-03-29 22:21:01 <-- PJosepherum (PJosepherum@user/PJosepherum) has quit (Ping timeout: 121 seconds)

2014-03-29 22:33:02 [22:33]

2014-03-29 22:33:15 PJosepherum well he didn't report safety, but didn't report unsafety lol

2014-03-29 22:34:42 PJosepherum definitely! it needs expanding. the current lore is way too dangerous, not enough emphasis on extraction and safety

2014-03-29 22:35:11 PJosepherum understanding the mechanism allows for mitigation of negative consequences

2014-03-29 22:36:13 PJosepherum good idea

2014-03-29 22:36:19 PJosepherum (with 500 mg, orally) "I took a half gram of pure synthetic harmaline after fasting for over a day. The resulting nausea was greatly attenuated after I vomited. At this dose there were intense and annoying visual disturbances, and complete collapse of motor co-ordination. I could barely stagger to the bathroom, and for safety's sake locomoted by crawling. Tracers and weird visual ripplings disturbed my sight with open eyes. With eyes clo

2014-03-29 22:39:26 PJosepherum i don't feel safe pushing it, but i really want to know how microdoses of harmalas feel

2014-03-29 22:40:52 PJosepherum i also think abstinence from external chemical influence like food or drugs is necessary for an ensured pleasant experience

2014-03-29 22:41:32 PJosepherum very. lol. if too much messengers build up in the axons, they can damage receptors

2014-03-29 22:42:25 PJosepherum receptors are hyperactivated, causing downstream distortions. the neuron mitigates the magnified signal by reducing the number of receptors presented on the membrane

2014-03-29 22:42:29 PJosepherum within the axon

2014-03-29 22:44:27 PJosepherum i can't discern which part of my eyes hurt and why. i think it's either a central headache from axon flooding or strained ocular muscles from the REM

2014-03-29 22:44:45 PJosepherum harmalas make me very twitchy

2014-03-29 22:45:30 PJosepherum caused by either GABA or epinephrine

2014-03-29 22:45:44 PJosepherum probably involves both

2014-03-29 22:46:38 PJosepherum 3g @ ~0.5% DMT

2014-03-29 22:46:51 PJosepherum so 15mg?

2014-03-29 23:01:38 PJosepherum lol

2014-03-29 23:01:45 PJosepherum again

2014-03-29 23:02:32 PJosepherum i know to be extra extra careful now. it's really not a good idea for the internet lore to suggest such a basic preparation of peganum harmala

2014-03-29 23:02:52 PJosepherum almost die, i haven't actually died yet