Promethazine: Difference between revisions

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{{headerpanel|{{Approval}}{{PromethazineOD}}}}
{{headerpanel|{{Approval}}{{PromethazineOD}}}}
{{SummarySheet}}
{{SummarySheet}}
{{Talk:SubstanceBox/Promethazine}}
{{SubstanceBox/Promethazine}}


'''Promethazine''' (commonly sold as '''Phenergan''' or '''Lergigan''') is a [[psychoactive class::depressant]] substance of the [[chemical class::phenothiazine]] class. Alongside codeine, it is popularly known as one of the active two ingredients in "lean". It acts as an [[antihistamine]].
'''Promethazine''' (commonly sold as '''Phenergan''' or '''Lergigan''') is a [[psychoactive class::depressant]] substance of the [[chemical class::phenothiazine]] class. Alongside codeine, it is popularly known as one of the active two ingredients in "lean". It acts as an [[antihistamine]].
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|{{effects/physical|
|{{effects/physical|


*'''[[Effect::Sedation]]''' - Promethazine causes pronounced sedation and a general feeling of slowness, usually with the feeling of not wanting to move, this effect is normally considerably stronger than Diphenhydramine or Doxylamine and it is generally considered to be one of the most sedating antihistamines due to its high anticholinergic, H1 anagonist and weak D2 antagonist activity.
*'''[[Effect::Sedation]]''' - Promethazine causes pronounced sedation and a general feeling of slowness, usually with the feeling of not wanting to move, this effect is normally considerably stronger than Diphenhydramine or Doxylamine and it is generally considered to be one of the most sedating antihistamines due to its high anticholinergic, H1 antagonist and weak D2 antagonist activity.


*'''[[Effect::Muscle relaxation]]'''
*'''[[Effect::Muscle relaxation]]'''
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==Legal status==
==Legal status==
{{LegalStub}}
*'''Germany''': Promethazine is available through a prescription.{{citation needed}}
 
*'''Germany''': Promethazine is available through a prescription.


*'''Russia''': Promethazine is available through a prescription.{{citation needed}}
*'''Russia''': Promethazine is available through a prescription.{{citation needed}}
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*'''United States''': Promethazine is available through a prescription.<ref>FDA. Promethazine Monograph. https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/07935s030lbl.pdf</ref>
*'''United States''': Promethazine is available through a prescription.<ref>FDA. Promethazine Monograph. https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/07935s030lbl.pdf</ref>


*'''Canada''': Promethazine is available over the counter.
*'''Canada''': Promethazine is available over the counter.{{citation needed}}
*'''Japan''': Promethazine is available through a prescription.
*'''Japan''': Promethazine is available through a prescription.{{citation needed}}
*'''Australia''': Promethazine is available over the counter.
*'''Australia''': Promethazine is available over the counter.{{citation needed}}
*'''United Kingdom''': Promethazine is available over the counter.
*'''United Kingdom''': Promethazine is available over the counter.{{citation needed}}
*'''Italy''': Promethazine is available over the counter, both as a cream and as a syrup in combination with paracetamol and DXM.{{citation needed}}
*'''The Netherlands''': Promethazine is available through a prescription.{{citation needed}}


==See also==
==See also==
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*[[wikipedia:Promethazine|Promethazine (Wikipedia)]]
*[[wikipedia:Promethazine|Promethazine (Wikipedia)]]
*[https://www.erowid.org/pharms/promethazine/ Promethazine (Erowid Vault)]
*[https://www.erowid.org/pharms/promethazine/ Promethazine (Erowid Vault)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=9438 Promethazine (TiHKAL / Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=9438 Promethazine (Isomer Design)]
*[https://go.drugbank.com/drugs/DB01069 Promethazine (DrugBank)]


==Literature==
==Literature==