Talk:Amitriptyline: Difference between revisions

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{{SubstanceBox/Amitriptyline}}'''Amitriptyline''' (trade name '''Elavil''' or '''Vanatrip''') is a [[Antidepressants#Tricyclics|tricyclic antidepressant]] drug used to treat depression, chronic neuropathic pain and migraines. It was ~~first~~ developed by the American pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] in the late 1950s. Amitriptyline is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line medication.

{{SubstanceBox/Amitriptyline}}'''Amitriptyline''' (trade name '''Elavil''' or '''Vanatrip''') is a [[Antidepressants#Tricyclics|tricyclic antidepressant]] drug used to treat depression, chronic neuropathic pain and migraines. It was the second known antidepressant and developed by the American pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] in the late 1950s. Amitriptyline is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line medication.

It is also rarely abused at strong and high doses for euphoric and sedative effects, though there is almost no information about its effects as a recreational drug

==History and culture==

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Pharmaceutical companies [https://en.wikipedia.org/wiki/Hoffmann-La_Roche Roche] and [https://en.wikipedia.org/wiki/Lundbeck Lundbeck] were also able to create patents on the drug thanks to a quirk of the patent law in the EU at the time allowing patents only on the chemical synthesis, but not on the drug itself.

The drug quickly surpassed its predecessor, [[imipramine]], because of its stronger anxiolytic effect and a campaign by the Merck company, raising awareness of depression as a clinical issue. Between 1998 and 2017 ~~amitryptaline~~ was the most prescribed antidepressant for 11-17 year olds in England

The drug quickly surpassed its predecessor, [[imipramine]], because of its stronger anxiolytic effect and a campaign by the Merck company, raising awareness of depression as a clinical issue. Between 1998 and 2017 amitriptyline was the most prescribed antidepressant for 11-17 year olds in England

== Chemistry ==

==Chemistry==

<br />

== Pharmacology ==

==Pharmacology==

<br />

== Subjective Effects ==

==Subjective Effects==

== Toxicity and harm potential ==

==Toxicity and harm potential==

<br />

== See also ==

==See also==

<br />

== External links ==

==External links==

*[https://en.wikipedia.org/wiki/Amitriptyline Amitriptyline (Wikipedia)]

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 <!-- kenan's mum is fat -->
-{{SubstanceBox/Amitriptyline}}'''Amitriptyline''' (trade name '''Elavil''' or '''Vanatrip''') is a [[Antidepressants#Tricyclics|tricyclic antidepressant]] drug used to treat depression, chronic neuropathic pain and migraines. It was first developed by the American pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] in the late 1950s. Amitriptyline is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line medication.
+{{SubstanceBox/Amitriptyline}}'''Amitriptyline''' (trade name '''Elavil''' or '''Vanatrip''') is a [[Antidepressants#Tricyclics|tricyclic antidepressant]] drug used to treat depression, chronic neuropathic pain and migraines. It was the second known antidepressant and developed by the American pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] in the late 1950s. Amitriptyline is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line medication.
+It is also rarely abused at strong and high doses for euphoric and sedative effects, though there is almost no information about its effects as a recreational drug
 ==History and culture==
@@ Line 7: / Line 9: @@
 Pharmaceutical companies [https://en.wikipedia.org/wiki/Hoffmann-La_Roche Roche] and [https://en.wikipedia.org/wiki/Lundbeck Lundbeck] were also able to create patents on the drug thanks to a quirk of the patent law in the EU at the time allowing patents only on the chemical synthesis, but not on the drug itself.
-The drug quickly surpassed its predecessor, [[imipramine]], because of its stronger anxiolytic effect and a campaign by the Merck company, raising awareness of depression as a clinical issue. Between 1998 and 2017 amitryptaline was the most prescribed antidepressant for 11-17 year olds in England
+The drug quickly surpassed its predecessor, [[imipramine]], because of its stronger anxiolytic effect and a campaign by the Merck company, raising awareness of depression as a clinical issue. Between 1998 and 2017 amitriptyline was the most prescribed antidepressant for 11-17 year olds in England
-== Chemistry ==
+==Chemistry==
 <br />
-== Pharmacology ==
+==Pharmacology==
 <br />
-== Subjective Effects ==
+==Subjective Effects==
 {{Preamble/SubjectiveEffects}}
-== Toxicity and harm potential ==
+==Toxicity and harm potential==
 <br />
-== See also ==
+==See also==
 <br />
-== External links ==
+==External links==
 *[https://en.wikipedia.org/wiki/Amitriptyline Amitriptyline (Wikipedia)]