Talk:Amitriptyline: Difference between revisions

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~~Found an old box~~ in ~~my attic that wasnt expired~~ and ~~did some human testing on my self~~.

{{SubstanceBox/Amitriptyline}}'''Amitriptyline''' (trade name '''Elavil''' or '''Vanatrip''') is a [[Antidepressants#Tricyclics|tricyclic antidepressant]] drug used to treat depression, chronic neuropathic pain and migraines. It was the second known antidepressant and developed by the American pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] in the late 1950s. Amitriptyline is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line medication.

~~They were 25mg pills.~~

It is also rarely abused at strong and high doses for euphoric and sedative effects, though there is almost no information about its effects as a recreational drug

~~I can only make~~ a ~~dosage~~ and ~~effects list~~.

==History and culture==

In the 1950s the pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] proposed clinical trials to use amitriptyline as a treatment for schizophrenia, researcher Frank Ayd instead suggested that the medication be used as an antidepressant. Ayd treated 130 patients with amitriptyline and reported that it had similar qualities to [[imipramine]], the first and only tricyclic antidepressant. It was approved for treatment of depression by the FDA in 1961.

~~Threshold 5 mg Light 5~~ - ~~15 mg Common 15 - 35 mg Strong 35 - 60 mg Heavy 60 mg +~~

Pharmaceutical companies [https://en.wikipedia.org/wiki/Hoffmann-La_Roche Roche] and [https://en.wikipedia.org/wiki/Lundbeck Lundbeck] were also able to create patents on the drug thanks to a quirk of the patent law in the EU at the time allowing patents only on the chemical synthesis, but not on the drug itself.

Effects: ~~Mostly hella sedation that leads to you falling asleep pretty quick~~. ~~But if u resist its a light cognitive euphoria and a nice body euphoria~~.

The drug quickly surpassed its predecessor, [[imipramine]], because of its stronger anxiolytic effect and a campaign by the Merck company, raising awareness of depression as a clinical issue. Between 1998 and 2017 amitriptyline was the most prescribed antidepressant for 11-17 year olds in England

==Chemistry==

==Pharmacology==

==Subjective Effects==

==Toxicity and harm potential==

==See also==

==External links==

*[https://en.wikipedia.org/wiki/Amitriptyline Amitriptyline (Wikipedia)]

*[https://www.drugbank.ca/drugs/DB00321 Amitriptyline (DrugBank)]

@@ Line 1: / Line 1: @@
-Found an old box in my attic that wasnt expired and did some human testing on my self.
+<!-- kenan's mum is fat -->
+{{SubstanceBox/Amitriptyline}}'''Amitriptyline''' (trade name '''Elavil''' or '''Vanatrip''') is a [[Antidepressants#Tricyclics|tricyclic antidepressant]] drug used to treat depression, chronic neuropathic pain and migraines. It was the second known antidepressant and developed by the American pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] in the late 1950s. Amitriptyline is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line medication.
-They were 25mg pills.
+It is also rarely abused at strong and high doses for euphoric and sedative effects, though there is almost no information about its effects as a recreational drug
-I can only make a dosage and effects list.
+==History and culture==
+In the 1950s the pharmaceutical company [https://en.wikipedia.org/wiki/Merck_%26_Co. Merck] proposed clinical trials to use amitriptyline as a treatment for schizophrenia, researcher Frank Ayd instead suggested that the medication be used as an antidepressant. Ayd treated 130 patients with amitriptyline and reported that it had similar qualities to [[imipramine]], the first and only tricyclic antidepressant. It was approved for treatment of depression by the FDA in 1961.
-Threshold 5 mg Light 5 - 15 mg Common 15 - 35 mg Strong 35 - 60 mg Heavy 60 mg +
+Pharmaceutical companies [https://en.wikipedia.org/wiki/Hoffmann-La_Roche Roche] and [https://en.wikipedia.org/wiki/Lundbeck Lundbeck] were also able to create patents on the drug thanks to a quirk of the patent law in the EU at the time allowing patents only on the chemical synthesis, but not on the drug itself.
-Effects: Mostly hella sedation that leads to you falling asleep pretty quick. But if u resist its a light cognitive euphoria and a nice body euphoria.
+The drug quickly surpassed its predecessor, [[imipramine]], because of its stronger anxiolytic effect and a campaign by the Merck company, raising awareness of depression as a clinical issue. Between 1998 and 2017 amitriptyline was the most prescribed antidepressant for 11-17 year olds in England
+==Chemistry==
+<br />
+==Pharmacology==
+<br />
+==Subjective Effects==
+{{Preamble/SubjectiveEffects}}
+==Toxicity and harm potential==
+<br />
+==See also==
+<br />
+==External links==
+*[https://en.wikipedia.org/wiki/Amitriptyline Amitriptyline (Wikipedia)]
+*[https://www.drugbank.ca/drugs/DB00321 Amitriptyline (DrugBank)]
+<br />